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Evaluating the Therapeutic Potential of MRT68921 and Afatinib in Three-Dimensional Models of Epithelial Ovarian Cancer. [PDF]

open access: yesCancers (Basel)
Johnston TPA   +6 more
europepmc   +1 more source

Epithelial–mesenchymal transition in ovarian cancer

Cancer Letters, 2010
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions. The conversion of an epithelial cell to a mesenchymal cell plays a key role
Daniele Vergara   +2 more
exaly   +4 more sources

Prevention of Epithelial Ovarian Cancer

Cold Spring Harbor Perspectives in Medicine, 2023
Given the challenges with achieving effective and durable treatment for epithelial ovarian cancer, primary prevention is highly desirable. Fortunately, decades of research have provided evidence for several strategies that can be deployed to optimize risk reduction. These include surgery, chemoprevention, and lifestyle factor modifications. These broad
Thomas A, Sellers   +3 more
openaire   +2 more sources

Alcohol and epithelial ovarian cancer

Journal of Clinical Epidemiology, 1992
The relationship between alcohol consumption and the risk of epithelial ovarian cancer was analysed using data from a case-control study of 801 histologically confirmed epithelial ovarian cancers and 2114 controls in hospital for acute, non-neoplastic, gynecological, or hormone-related conditions, admitted to a network of teaching and general hospitals
C. La Vecchia   +5 more
openaire   +2 more sources

Estrogens and epithelial ovarian cancer

Gynecologic Oncology, 2004
Molecular mechanisms involved in ovarian carcinogenesis are still unclear, but there is growing evidence that estrogens promote tumor progression in an epithelial ovarian cancer (EOC) subgroup.We reviewed current knowledge on the effects of estrogens in ovarian carcinogenesis and new potential research focuses concerning hormonal therapy of EOC ...
Séverine, Cunat   +2 more
openaire   +2 more sources

Epithelial ovarian cancer

Current Treatment Options in Oncology, 2002
Epithelial ovarian cancer is the most lethal of all gynecologic malignancies. Most women have advanced stage disease. Access to appropriate initial surgical management by a gynecologic oncologist is important because treatment and survival are affected by appropriate surgical staging and debulking of tumor. After debulking/staging surgery, chemotherapy
openaire   +3 more sources

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