Results 121 to 130 of about 1,366,174 (281)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

Epithelial and Topographic Corneal Remodeling After Ptosis and Ectropion Surgery: An MS-39-Based Study

Diagnostics
Background/Objectives: Eyelid malpositions can alter corneal shape through chronic mechanical forces, yet conventional topographic devices do not distinguish epithelial from stromal contributions to these changes.
Maria Angela Romeo, Vanessa Ferraro, Alessandro Gaeta, Novella Montericcio, Giovanni Ottonelli, Silvia Ferraro, Giuseppe Giannaccare, Alessandra Di Maria   +7 more
doaj   +1 more source

Corneal Epithelial Thickness in Sjogren’s Disease: A Pilot Study

Brian J Nguyen,1 Angela S Gupta,1 Jocelyn He,1,2 Gui-Shuang Ying,1,2 Vatinee Y Bunya,1 Ilaria Macchi,1 Mina Massaro-Giordano1 1Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA; 2Department of ...
Bunya VY, Macchi I, He J, Ying GS, Gupta AS, Nguyen BJ, Massaro-Giordano M   +6 more
core  

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Epithelial and stromal thickness profile and lens decentration in myopic orthokeratology

Journal of Optometry
To study topographic epithelial and total corneal thickness changes in myopic subjects undergoing successful orthokeratology treatment in connection with the objective assessment of contact lens decentration.A prospective-observational and non-randomized study in 32 Caucasian myopic eyes undergoing Ortho-k for 3 months.
J. González-Pérez, A. Sánchez-García, M.A. Parafita   +2 more
openaire   +3 more sources

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

Corneal epithelium is altered in keratoconus and forme fruste keratoconus

Scientific Reports
This study investigated corneal epithelial thickness and its distribution in keratoconus (KC) and forme fruste keratoconus (FFK). A total of 35 KC eyes, 25 FFK eyes, and 35 control eyes underwent anterior segment-optical coherence tomography for corneal ...
Nomuundari Sukhee, Hiroyuki Namba, Marie Ikeda, Sera Ichinohasama, Tomoyuki Kurihara, Nene Okamoto, Junko Yoshida, Tomohiko Usui   +7 more
doaj   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Comparative analysis of epithelial remodeling after photorefractive keratectomy and keratorefractive lenticule extraction for myopia

Indian Journal of Ophthalmology
Purpose: This study aims to characterize and compare the patterns of epithelial remodeling following photorefractive keratectomy (PRK) and femtosecond small incision lenticule extraction (Femto-SMILE) using high-resolution anterior segment optical ...
Ahmed Elmassry, Amr Habib, Ihab M Osman, Safaa M Abozahra, Ramy Awad   +4 more
doaj   +1 more source