Results 91 to 100 of about 311,587 (357)

Epithelial-mesenchymal markers and their correlation with clinical aspects in odontogenic keratocysts

RGO: Revista Gaúcha de Odontologia, 2022
Objective: Odontogenic keratocysts have a high recurrence rate and aggressive clinical behavior. The event called epithelial-mesenchymal transition is a process in which the epithelial cell loses its epithelial characteristics and acquires properties ...
Joana Leticia VENDRUSCOLO, Mariana de SOUZA LESSA, Sergio OSSAMU IOSHII, Juliana Lucena SCHUSSEL, Laurindo Moacir SASSI   +4 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Induction and Analysis of Epithelial to Mesenchymal Transition [PDF]

Journal of Visualized Experiments, 2013
Epithelial to mesenchymal transition (EMT) is essential for proper morphogenesis during development. Misregulation of this process has been implicated as a key event in fibrosis and the progression of carcinomas to a metastatic state. Understanding the processes that underlie EMT is imperative for the early diagnosis and clinical control of these ...
Wade Johnson, Yixin Tang, Greg Herr, Ernesto Resnik, Joy Aho   +4 more
openaire   +3 more sources

Mapping lung cancer epithelial-mesenchymal transition states and trajectories with single-cell resolution. [PDF]

, 2019
Elucidating the spectrum of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in clinical samples promises insights on cancer progression and drug resistance.
Anchang, Benedict, Bendall, Sean C, Benson, Jalen A, Ignatiadis, Nikolaos, Karacosta, Loukia G, Kimmey, Samuel C, Plevritis, Sylvia K, Shrager, Joseph B, Tibshirani, Robert   +8 more
core  

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [PDF]

, 2009
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT).
Akitaya, Alkhateeb, Andersson, Barrallo-Gimeno, Bertocchini, Chea, Ciruna, del Barrio, Dixon, Dottori, el Ghouzzi, Favier, Gans, Garcia-Castro, Giehl, Haraguchi, Hervé Acloque, Iwano, Johansson, Kalluri, Katherine Fishwick, Kitajima, Kos, Kwok, Liu, Liu, M. Angela Nieto, Manzanares, Marianne Bronner-Fraser, Martin, Mathieu, Meghan S. Adams, Moreno-Bueno, Nakagawa, Nakaya, Nieto, Peinado, Perea-Gomez, Perez-Pomares, Pijnenborg, Popperl, Sato, Sela-Donenfeld, Sela-Donenfeld, Selleck, Shah, Skromne, Tanimizu, Thiery, Varlet   +49 more
core   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The mechanisms of colorectal cancer cell mesenchymal–epithelial transition induced by hepatocyte exosome-derived miR-203a-3p

Journal of Bio-X Research, 2018
. Phosphatase of regenerating liver 3 (PRL3) promotes colorectal cancer (CRC) metastasis by inducing epithelial-to-mesenchymal transition. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed
Heyang Xu, MD, Yongliang Huang, MD, Qiusheng Lan, MD, Yang Zhang, MD, Yujie Zeng, PhD, Tao Zhang, BA, Chisheng Chen, MD, Pengwei Su, BA, Ziqiang Chu, BA, Wei Lai, MD, Zhonghua Chu, MD   +10 more
doaj   +1 more source

Cancer chemoprevention through Frizzled receptors and EMT

Discover Oncology, 2021
Frizzled (FZD) transmembrane receptors are well known for their role in β-catenin signaling and development and now understanding of their role in the context of cancer is growing.
K. Sompel, A. Elango, A. J. Smith, M. A. Tennis   +3 more
doaj   +1 more source

BDNF/TrkB axis activation promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis [PDF]

, 2017
Background: Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a possible role in lung health and ...
Bruno, Pierdonato, Cardillo, Giuseppe, Cherubini, Emanuela, D'Ascanio, Michela, Mancini, Rita, Mariotta, Salvatore, Osman, GIORGIA AMIRA, Ricci, Alberto, Scozzi, Davide   +8 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source