Results 141 to 150 of about 244,147 (243)

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

Pseudogenes in the carcinogenesis: epithelial-to-mesenchymal transition process and cancer initiating cells. [PDF]

Rep Pract Oncol Radiother
Kolenda T, Chałaj P, Cichowicz A, Trojańska A, Bałoniak A, Kwaśniewska M, Odrobińska M, Guglas K, Kozłowska-Masłoń J, Gieremek P, Poter P, Janiczek-Polewska M, Florczak-Substyk A, Przybyła A, Mantaj P, Regulska K, Stanisz BJ, Cybulski Z, Kazimierczak U.   +18 more
europepmc   +1 more source

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

Proceedings of the National Academy of Sciences of the United States of America, 2010
J. Taube, Jason I Herschkowitz, K. Komurov, A. Zhou, Supriya Gupta, Jing Yang, Kimberly A. Hartwell, T. Onder, Piyush B. Gupta, K. Evans, B. Hollier, Prahlad T. Ram, E. Lander, J. Rosen, R. Weinberg, Sendurai A Mani   +15 more
semanticscholar   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

HOTAIR requires epitranscriptomic modification to exert its pivotal epigenetic role in Epithelial to Mesenchymal Transition. [PDF]

Cell Death Dis
Garbo S, Minotti S, Marocco F, Quattrocchi L, Di Silverio I, Bontempi G, Strippoli R, Tripodi M, Battistelli C.   +8 more
europepmc   +1 more source

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis.

Cancer Research, 2006
J. Christiansen, A. Rajasekaran
semanticscholar   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Epithelial-to-mesenchymal transition drives cancer genomic instability. [PDF]

J Exp Clin Cancer Res
Carstens JL, Lovisa S.
europepmc   +1 more source

ZEB1 drives epithelial-to-mesenchymal transition in lung cancer.

Journal of Clinical Investigation, 2016
Jill Larsen, V. Nathan, Jihan K. Osborne, Rebecca Farrow, Dhruba Deb, J. Sullivan, Patrick D Dospoy, A. Augustyn, Suzie K. Hight, Mitsuo Sato, L. Girard, C. Behrens, I. Wistuba, A. Gazdar, N. Hayward, J. Minna   +15 more
semanticscholar   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source