TLR3 activation mediates partial epithelial-to-mesenchymal transition in human keratinocytes. [PDF]
Schneider AM+9 more
europepmc +1 more source
Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells [PDF]
Russell A. Morton+4 more
openalex +1 more source
Piezoelectric microdevices, composed of ZnO nanosheets acting as nanogenerators and grown on silicon microparticles, are designed and fabricated to deliver precise electrical cell stimulation. This study optimizes nanosheet growth and microparticle size to enhance electrical cell activation performance while minimizing cellular internalization.
Laura Lefaix+4 more
wiley +1 more source
CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway. [PDF]
Han Q+12 more
europepmc +1 more source
Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo+17 more
wiley +1 more source
Corrigendum: Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer. [PDF]
Yang HW+11 more
europepmc +1 more source
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen+12 more
wiley +1 more source
Reversal of epithelial to mesenchymal transition in triple negative breast cancer through epigenetic modulations by dietary flavonoid Galangin and its combination with SAHA. [PDF]
Nimal S+5 more
europepmc +1 more source
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source