Results 111 to 120 of about 1,205,235 (393)

Pendrin stimulates a chloride absorption pathway to increase CFTR‐mediated chloride secretion from Cystic Fibrosis airway epithelia

FASEB BioAdvances, 2020
Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete anions from epithelia.
Jeffrey Bajko, Mei Duguid, Steve Altmann, Gregory D. Hurlbut, J. Stefan Kaczmarek   +4 more
doaj   +1 more source

Lineage-negative Progenitors Mobilize to Regenerate Lung Epithelium after Major Injury

Nature, 2014
Broadly, tissue regeneration is achieved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized stem/progenitor cells. Which of these pathways applies is both organ- and injury-specific.
A. Vaughan, A. Brumwell, Y. Xi, J. Gotts, D. Brownfield, Barbara Treutlein, Kevin Tan, Victor Tan, Fengchun Liu, M. Looney, M. Matthay, J. Rock, H. Chapman   +12 more
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Observation of Dynamic Cellular Migration of the Medial Edge Epithelium of the Palatal Shelf in vitro

Frontiers in Physiology, 2019
Palatal fusion is a critical step during palatogenesis. In this fusing interface, the epithelial sheets need to be removed in order to achieve mesenchymal continuity.
Gozo Aoyama, Hiroshi Kurosaka, Ayaka Oka, Kohei Nakatsugawa, Sayuri Yamamoto, Safiye Esra Sarper, Safiye Esra Sarper, Yu Usami, Satoru Toyosawa, Toshihiro Inubushi, Yukako Isogai, Takashi Yamashiro   +11 more
doaj   +1 more source

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

Frontiers in Cell and Developmental Biology, 2020
Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the ...
Anu Laulajainen-Hongisto, Anu Laulajainen-Hongisto, Sanna Katriina Toppila-Salmi, Sanna Katriina Toppila-Salmi, Annika Luukkainen, Robert Kern   +5 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]

, 2015
Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey, Cordero, Julia, Naszai, Mate   +2 more
core   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Perturbed Mitochondrial Dynamics Is a Novel Feature of Colitis That Can Be Targeted to Lessen DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (ie,
Nicole L. Mancini, Luke Goudie, Warren Xu, Rasha Sabouny, Sruthi Rajeev, Arthur Wang, Nicolas Esquerre, Ala Al Rajabi, Timothy S. Jayme, Erik van Tilburg Bernandes, Yasmin Nasser, José G.P. Ferraz, Timothy Shutt, Jane Shearer, Derek M. McKay   +14 more
doaj  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source