Frontiers in Cellular and Infection Microbiology, 2017 Pseudomonas aeruginosa (Pa) is the leading cause of chronic lung infection in Cystic Fibrosis (CF) patients. It is well recognized that CF epithelial cells fail to develop an appropriate response to infection, allowing bacterial colonization and a ...
Viviane Balloy +8 more
doaj +1 more source
Proteome changes of sheep rumen epithelium during postnatal development
Frontiers in Genetics, 2022 Background: The development of the rumen epithelium is a critical physiological challenge for sheep. However, the molecular mechanism underlying postnatal rumen development in sheep remains rarely understood.Results: Here, we used a shotgun approach and ...
Kaizhi Zheng +8 more
doaj +1 more source
PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host-microbe intersection during SIV infection. [PDF]
, 2019 Chronic gut inflammatory diseases are associated with disruption of intestinal epithelial barriers and impaired mucosal immunity. HIV-1 (HIV) causes depletion of mucosal CD4+ T cells early in infection and disruption of gut epithelium, resulting in ...
Arredondo, Juan +13 more
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Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]
, 2017 BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de +5 more
core +1 more source
Cytokine interactions with epithelium [PDF]
Canadian Journal of Gastroenterology and Hepatology, 1994 Cytokines are a family of proteins that serve as intracellular messengers within the immune system and as growth factors for several cell types. Recent studies indicate that intestinal inflammation is accompanied by increases in a wide variety of cytokines and growth factors.
openaire +3 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Flagellin induces β-defensin 2 in human colonic ex vivo infection with enterohemorrhagic Escherichia coli [PDF]
, 2016 Enterohemorrhagic E. coli (EHEC) is an important foodborne pathogen in the developed world and can cause life-threatening disease particularly in children.
Chan, Simon +6 more
core +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β\u3csub\u3e2\u3c/sub\u3e-agonist use [PDF]
, 2006 Background Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement.
Batra, Vikas +8 more
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Immunohistochemical detection of macrophage migration inhibitory factor in fetal and adult bovine epididymis: Release by the apocrine secretion mode? [PDF]
, 2006 Originally defined as a lymphokine inhibiting the random migration of macrophages, the macrophage migration inhibitory factor (MIF) is an important mediator of the host response to infection.
Agarwal A. +57 more
core +1 more source