The Brassica epithionitrile 1‐cyano‐2,3‐epithiopropane triggers cell death in human liver cancer cells in vitro [PDF]
Molecular Nutrition & Food Research, 2015 ScopeGlucosinolates are secondary metabolites present in Brassica vegetables. Alkenyl glucosinolates are enzymatically degraded forming nitriles or isothiocyanates, but in the presence of epithiospecifier protein, epithionitriles are released. However, studies on the occurrence of epithionitriles in Brassica food and knowledge about their biological ...
Hanschen, Franziska S. +7 more
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Metabolism and Recovery of Epithionitriles from Glucosinolates—A Human Intervention Study [PDF]
Molecular Nutrition & Food Research, 2022 ScopeEpithionitriles can be main glucosinolate hydrolysis products in Brassica vegetables such as cabbage or pak choi. Here, for the first time, the bioavailability and metabolism of longer‐chain epithionitriles (C4–C5) is studied in a human intervention study.Methods and resultsAfter consumption of a white cabbage or pak choi sprouts beverage, rich in
Holger Hoffmann +5 more
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CO2 treatment increases glucosinolate hydrolysis products in two Arabidopsis thaliana accessions [PDF]
Journal of Applied Botany and Food Quality, 2021 Brassicales include many vegetables of nutritional interest because the hydrolysis products of their phytochemicals, the glucosinolates, have health-promoting properties.
Melanie Wiesner-Reinhold +4 more
doaj +3 more sources
Structural diversification during glucosinolate breakdown: mechanisms of thiocyanate, epithionitrile and simple nitrile formation [PDF]
The Plant Journal, 2019 SummarySecondary metabolism is characterized by an impressive structural diversity. Here, we have addressed the mechanisms underlying structural diversification upon damage‐induced activation of glucosinolates, a group of thioglucosides found in the Brassicales.
Daniela Eisenschmidt‐Bönn +4 more
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Isothiocyanates, Nitriles, and Epithionitriles from Glucosinolates Are Affected by Genotype and Developmental Stage in Brassica oleracea Varieties [PDF]
Frontiers in Plant Science, 2017 Vegetables of the Brassica oleracea group, such as broccoli, cauliflower, and cabbage, play an important role for glucosinolate consumption in the human diet. Upon maceration of the vegetable tissue, glucosinolates are degraded enzymatically to form volatile isothiocyanates, nitriles, and epithionitriles.
Hanschen, Franziska S. +1 more
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The in vitro toxicity of nitrile and epithionitrile derivatives of glucosinolates from rutabaga in human and bovine liver cells [PDF]
, 2018 Previous evidence suggests that select nitrile and epithionitrile derivatives of glucosinolates can cause liver disease in cows grazing on brassica forage crops. A toxic incidence in New Zealand in cattle grazing brassica led us to investigate the direct in vitro hepatotoxicity and possible inhibition of the ABCG2 transporter of five nitrile compounds.
Latimer, Ian +4 more
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First experimental evidence suggests use of glucobrassicin as source of auxin in drought-stressed Arabidopsis thaliana [PDF]
Frontiers in Plant Science, 2022 The synthesis of indole-3-acetonitrile (IAN) from the indolic glucosinolate (iGSL) glucobrassicin (GB) is a unique trait of members of the Brassicales.
Johann Hornbacher +7 more
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Iron is a centrally bound cofactor of specifier proteins involved in glucosinolate breakdown. [PDF]
PLoS ONE, 2018 Glucosinolates, a group of sulfur-rich thioglucosides found in plants of the order Brassicales, have attracted a lot of interest as chemical defenses of plants and health promoting substances in human diet.
Anita Backenköhler +5 more
doaj +5 more sources
Journal of Chemical Ecology, 2008 Cruciferous plants (Brassicaceae) are characterized by the accumulation of a group of secondary metabolites known as glucosinolates that, following attack by pathogens or herbivores, may be hydrolyzed to one of a number of products including isothiocyanates and nitriles.
Pope, T. W. +5 more
openaire +3 more sources
Chemopreventive glucosinolate accumulation in various broccoli and collard tissues: Microfluidic-based targeted transcriptomics for by-product valorization. [PDF]
PLoS ONE, 2017 Floret, leaf, and root tissues were harvested from broccoli and collard cultivars and extracted to determine their glucosinolate and hydrolysis product profiles using high performance liquid chromatography and gas chromotography.
Young-Sang Lee +3 more
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