Results 1 to 10 of about 249 (114)

Structural diversification during glucosinolate breakdown: mechanisms of thiocyanate, epithionitrile and simple nitrile formation. [PDF]

Plant J, 2019
SummarySecondary metabolism is characterized by an impressive structural diversity. Here, we have addressed the mechanisms underlying structural diversification upon damage‐induced activation of glucosinolates, a group of thioglucosides found in the Brassicales.
Eisenschmidt-Bönn D, Schneegans N, Backenköhler A, Wittstock U, Brandt W.   +4 more
europepmc   +6 more sources

Metabolism and Recovery of Epithionitriles from Glucosinolates—A Human Intervention Study

Molecular Nutrition & Food Research, 2022
ScopeEpithionitriles can be main glucosinolate hydrolysis products in Brassica vegetables such as cabbage or pak choi. Here, for the first time, the bioavailability and metabolism of longer‐chain epithionitriles (C4–C5) is studied in a human intervention study.Methods and resultsAfter consumption of a white cabbage or pak choi sprouts beverage, rich in
Holger Hoffmann, Susanne Baldermann, Melanie Wiesner‐Reinhold, Manuela M. Bergmann, Tilman Grune, Franziska S. Hanschen   +5 more
openaire   +3 more sources

Identification Of N-Acetyl-S-(3-Cyano-2-(Methylsulfanyl)Propyl-Cysteine as a Major Human Urine Metabolite from the Epithionitrile 1-Cyano-2,3-Epithiopropane, the Main Glucosinolate Hydrolysis Product from Cabbage. [PDF]

Nutrients, 2019
Brassica vegetables such as cabbage or pak choi contain alkenyl glucosinolates which can release epithionitriles and to a lesser degree isothiocyanates upon enzymatic hydrolysis. Here, for the first time, the metabolism of an epithionitrile was investigated in humans, namely 1-cyano-2,3-epithiopropane (CETP). After consumption of Brassica oleracea var.
Hanschen FS, Baldermann S, Brobrowski A, Maikath A, Wiesner-Reinhold M, Rohn S, Schreiner M.   +6 more
europepmc   +5 more sources

First experimental evidence suggests use of glucobrassicin as source of auxin in drought-stressed Arabidopsis thaliana. [PDF]

Front Plant Sci, 2022
The synthesis of indole-3-acetonitrile (IAN) from the indolic glucosinolate (iGSL) glucobrassicin (GB) is a unique trait of members of the Brassicales.
Hornbacher J, Horst-Niessen I, Herrfurth C, Feussner I, Papenbrock J.   +4 more
europepmc   +3 more sources

Iron is a centrally bound cofactor of specifier proteins involved in glucosinolate breakdown. [PDF]

PLoS One, 2018
Glucosinolates, a group of sulfur-rich thioglucosides found in plants of the order Brassicales, have attracted a lot of interest as chemical defenses of plants and health promoting substances in human diet.
Backenköhler A, Eisenschmidt D, Schneegans N, Strieker M, Brandt W, Wittstock U.   +5 more
europepmc   +4 more sources

Development of a Gas Chromatography-Time-of-Flight Method for Detecting Glucosinolate Metabolites and Volatile Organic Compounds in Kimchi. [PDF]

Int J Anal Chem, 2021
This study examined the volatile organic compounds (VOCs) and metabolites of glucosinolate (GLS) contained in kimchi and analyzed GLS using myrosinase. The analysis was conducted using gas chromatography‐time of flight (GC‐TOF), and VOC and the metabolite quantities were detected and analyzed.
Kim HJ, Lee MJ, Hur SH, Jeong MH.
europepmc   +2 more sources

Sulforaphane and ophthalmic diseases. [PDF]

Food Sci Nutr
Sulforaphane (SFN) is an organosulfur compound categorized as an isothiocyanate (ITC), primarily extracted from cruciferous vegetables like broccoli and cabbage. This review comprehensively outlines recent research on SFN, elucidates its mechanisms of action, and discusses potential therapeutic benefits for eye disorders such as age‐related macular ...
Zhang Y, Zhao X, Liu Y, Yang X.
europepmc   +2 more sources

Cooked Broccoli Alters Cecal Microbiota and Impacts Microbial Metabolism of Glucoraphanin in Lean and Obese Mice. [PDF]

Mol Nutr Food Res
Seven‐day cooked broccoli feeding increased the ability of the gut microbiota to metabolize glucoraphanin (GRP) into beneficial isothiocyanates (ITCs) leading to increased colonic NQO1 activity. Gut microbiota shifted, with Lachnospiraceae NK4A136 group and Dubosiella newyorkensis increasing on broccoli diet.
Zhao A, Li J, Peterson M, Black M, Gaulke CA, Jeffery EH, Miller MJ.   +6 more
europepmc   +2 more sources

Chemical Composition and Antimicrobial Activity of Subcritical CO₂ Extract of Lepidium latifolium L. (Brassicaceae). [PDF]

Int J Biomater, 2021
The genus Lepidium L. from Brassicaceae Burnett. family covers over 150 species with an almost cosmopolitan spread. In Kazakhstan, 21 species are described, of which four species are characterized by medicinal properties (L. crassifolium Waldst. et Kit., L. perfoliatum L., L. ruderale L., and L.
Azimkhanova BB, Ustenova GO, Sharipov KO, Rakhimov KD, Sayakova GM, Jumagaziyeva AB, Flisyuk EV, Gemejiyeva NG.   +7 more
europepmc   +2 more sources

Diversified glucosinolate metabolism: biosynthesis of hydrogen cyanide and of the hydroxynitrile glucoside alliarinoside in relation to sinigrin metabolism in Alliaria petiolata. [PDF]

Front Plant Sci, 2015
Alliaria petiolata (garlic mustard, Brassicaceae) contains the glucosinolate sinigrin as well as alliarinoside, a γ-hydroxynitrile glucoside structurally related to cyanogenic glucosides.
Frisch T, Motawia MS, Olsen CE, Agerbirk N, Møller BL, Bjarnholt N.   +5 more
europepmc   +3 more sources