Results 161 to 170 of about 255,717 (257)

Differentiating naturally occurring and disease associated autoantibodies in MPO-ANCA vasculitis through immunogenomic and epitope comparisons. [PDF]

Front Med (Lausanne)
Chen DP, Moon YH, Peck BA, Taylor JJ, Gomez-Martinez I, Woodcock MG, Vincent BG, Falk RJ, Poulton JS, Bunch DO.   +9 more
europepmc   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Neutralizing epitope mapping for deltacoronavirus receptor-binding domain and seroepidemiological survey across different animal species. [PDF]

Virulence
Li D, Hao L, Huang B, Wang Z, Wang Z, Guo M, Zhang Y, Deng J, Li Y, Zhao S, Tian K, Li X.   +11 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Preliminary Immunogenicity Evaluation of an Immunoinformatics-Guided Multi-Epitope mRNA Vaccine Against Porcine Epidemic Diarrhea Virus. [PDF]

Vaccines (Basel)
Liu Y, Huang H, Chen Y, Shu J, Wu F.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

<i>In silico</i> design and experimental validation of a multi-epitope vaccine candidate against <i>Helicobacter hepaticus</i> associated chronic liver inflammation. [PDF]

Front Immunol
Weng L, Huijie Z, Man N, Yang L, Cao M.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Screening Epitopes Through Comparative Analysis of Children and Mice Immune Responses to Pertussis Toxin Subunits (S1-S5) Induced by Whole-Cell Pertussis Vaccination. [PDF]

Vaccines (Basel)
De-Simone SG, Lechuga GC, Napoleão-Pêgo P, Freitas MS, Cardozo SV, Morel CM, Provance DW, da Silva FR.   +7 more
europepmc   +1 more source