Results 151 to 160 of about 255,440 (257)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Neutralizing epitope mapping for deltacoronavirus receptor-binding domain and seroepidemiological survey across different animal species. [PDF]

Virulence
Li D, Hao L, Huang B, Wang Z, Wang Z, Guo M, Zhang Y, Deng J, Li Y, Zhao S, Tian K, Li X.   +11 more
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

<i>In silico</i> design and testing of a multi-epitope camel mastitis vaccine candidate for development. [PDF]

Front Cell Infect Microbiol
Murungi E, Langat N, Masila E, Onywera R, Ogali I, Gicheru N, Wesonga H, Maichomo M.   +7 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Assessing VirScan serosurvey epitope profiling variability between in-clinic venous blood draw and capillary blood self-sampling device. [PDF]

Microbiol Spectr
Sircy LM, Stevens-Ayers TL, Krantz EM, Joncas-Schronce L, Ozbek NSO, Blazevic RL, Mose L, Kimball LE, Basom R, Dasgupta S, Heit A, Schmitz F, Heckerman D, Bender Ignacio RA, Hill JA, Boonyaratanakornkit J, Boeckh M, Waghmare A.   +17 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Generation, characterization and epitope mapping of monoclonal antibody 4H3 specific to the HN protein of pigeon paramyxovirus type 1 (PPMV-1). [PDF]

Front Microbiol
Wang X, Ren H, Li P, Huang Z, Li X, Wang Y, Li Y, Liang L, Li J.   +8 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Differentiating naturally occurring and disease associated autoantibodies in MPO-ANCA vasculitis through immunogenomic and epitope comparisons. [PDF]

Front Med (Lausanne)
Chen DP, Moon YH, Peck BA, Taylor JJ, Gomez-Martinez I, Woodcock MG, Vincent BG, Falk RJ, Poulton JS, Bunch DO.   +9 more
europepmc   +1 more source