Results 21 to 30 of about 4,322 (264)

Data Management in Distributed, Federated Research Infrastructures: The Case of EPOS

Data Science Journal
Data management is a key activity when Open Data stewardship through services complying with the FAIR principles is required, as it happens in many National and European initiatives.
Daniele Bailo, Rossana Paciello, Jan Michalek, Daniela Mercurio, Agata Sangianantoni, Kauzar Saleh Contell, Otto Lange, Giovanna Maracchia, Kuvvet Atakan, Keith G. Jeffery, Carmela Freda   +10 more
doaj   +1 more source

Autocrine stimulation by erythropoietin (Epo) requires Epo secretion [PDF]

Blood, 1994
Abstract Erythropoietin (Epo) autocrine stimulation has been implicated in erythroblastic leukemia. To examine whether this stimulation could occur intracellularly, we developed Epo autocrine models of stimulation in the human pluripotent UT-7 cell line. Retroviral expression of Epo totally abolished the growth factor requirement of UT-7
J L, Villeval, M T, Mitjavila, I, Dusanter-Fourt, F, Wendling, P, Mayeux, W, Vainchenker   +5 more
openaire   +3 more sources

EPOS 4 Patients

Rhinology journal, 2021
EPOS2020 is the 4th and most recent version of the European Position Paper on Rhinosinusitis and Nasal Polyps which was first published in 2005. It aims to provide the most up to date scientifically robust information on the topic published in the literature which has been critically analysed by an international group of clinicians drawn from all ...
Hopkins, C., Surda, P., Walker, A., Wolf, A., Speth, M.M., Jacques, T., Hox, V., Van Gerven, L., Santamaria-Gadea, A., Segboer, C., Lourijsen, E., Turri-Zanoni, M., Huart, C., Rennie, C., Green, R., The Samter's Society, Kelly, C.E., Knill, A., Lund, V.J., Fokkens, W.J.   +19 more
openaire   +7 more sources

Advancements and Prospects in Electro-Sinter-Forging

Metals, 2022
A summary of the recent advancements, future prospects and open issues in the materials, methods and machines for the technology known as electro-sinter-forging is presented here.
Alessandro Fais
doaj   +1 more source

Emerging EPO and EPO receptor regulators and signal transducers [PDF]

Blood, 2015
AbstractAs essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal ...
David, Kuhrt, Don M, Wojchowski
openaire   +2 more sources

EPO tecting the Endothelium [PDF]

British Journal of Pharmacology, 2007
Erythropoietin is a 30.4 kDa protein that is produced and secreted from the kidney in response to anemia and hypobaric hypoxia. Binding of EPO to its receptor (EPO‐R) on bone marrow‐derived erythroid progenitor cells results in the stimulation of red blood cell production. Evidence is accumulating however, that the biological effects of recombinant EPO
T E, Peterson, Z S, Katusic
openaire   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source