Results 221 to 230 of about 115,061 (305)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

open access: yesBritish Journal of Pharmacology, EarlyView.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl   +3 more
wiley   +1 more source

Multiparasitism Resolves the Apparent Paradox of High Male Pheromone Investment Despite Frequent Within‐Host Mating in a Parasitoid

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
It is unknown why males of the parasitoid wasp Nasonia giraulti produce large amounts of a costly sex pheromone although they were long thought to mate with their females already before emergence within the host. Mated females do no longer respond to the pheromone.
Martina Wendler   +2 more
wiley   +1 more source

Transmission electron microscopy characterisation of Spirulina bioplastics

open access: yesJournal of Microscopy, EarlyView.
Abstract Plastic pollution is impacting global ecosystem health. Bioplastics made from unprocessed biomass, including whole or fragmented tissues, are one potential solution. They are biodegradable and exhibit competitive mechanical performance. Seaweed and microalgae have gained popularity over the last decade as bioplastic feedstocks due to their ...
Sourena Azidhak   +4 more
wiley   +1 more source

Are bio‐based resins suitable alternatives for additively manufactured removable dies? An in vitro study on dimensional and positional trueness and stability

open access: yesJournal of Prosthodontics, EarlyView.
Abstract Purpose This study aimed to compare the dimensional and positional deviations of additively manufactured removable dies fabricated using two bio‐based resins and one conventional dental cast resin, while also evaluating these outcomes over a 4‐week period.
Mustafa Borga Dönmez   +6 more
wiley   +1 more source

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