Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during
mBio, 2016 Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman +2 more
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Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia [PDF]
Current Research in Structural Biology, 2021 Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate epoxide ring in
Noor M. Taher +8 more
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Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network [PDF]
Computational and Structural Biotechnology Journal, 2022 Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the ...
Karolina Mitusińska +7 more
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Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 (R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke.
Dong Zhang +5 more
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Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters [PDF]
Biomolecules, 2022 Juvenile hormone epoxide hydrolase (JHEH) plays an important role in the metabolism of JH III in insects. To study the control of JHEH in female Drosophila melanogaster, JHEH 1, 2 and 3 cDNAs were cloned and sequenced.
Dov Borovsky +6 more
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Evolution of tunnels in α/β-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? [PDF]
PLoS Computational Biology, 2022 The evolutionary variability of a protein's residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are ...
Maria Bzówka +7 more
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The prognostic significance of epoxide hydrolases in colorectal cancer [PDF]
Biochemistry and Biophysics ReportsColorectal cancer (CRC) is a common malignant cancer. Epoxide hydrolases (EHs) are involved in the development of cancer by regulating epoxides, but their relationship with CRC is unclear.
Lichao Cao +5 more
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New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Two novel epoxide hydrolases (EHs), Sibe-EH and CH65-EH, were identified in the metagenomes of samples collected in hot springs in Russia and China, respectively.
Erica Elisa Ferrandi +8 more
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Time‐of‐Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins [PDF]
ExplorationModulation of circadian rhythms impairs homeostasis, resulting in altered susceptibility to disease development. New perspectives on nutrition emphasize the circadian timing of food intake.
Yanjun Liu +6 more
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Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function [PDF]
Journal of Lipid Research, 2018 Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi +6 more
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