Results 21 to 30 of about 3,732 (161)
Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy
Frontiers in Cardiovascular Medicine, 2022 ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski +15 more
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Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity
Data in Brief, 2016 The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira +5 more
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Dose-Response, 2004 From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed.
Franz Oesch +2 more
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The role of soluble epoxide hydrolase and its inhibitors in depression
Brain, Behavior, & Immunity - Health, 2021 Evidence suggests that around 30 % of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
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Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
PLoS ONE, 2017 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes +8 more
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Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?
Molecules, 2015 Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions.
Isabel Bordes +3 more
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Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]
Physiological Reviews, 2012 Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
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Anti-tubercular activity of a natural stilbene and its synthetic derivatives
GMS Infectious Diseases, 2018 Objectives: Tuberculosis (TB) and multidrug- and extensively drug-resistant TB in particular are remaining a major global health challenge and efficient new drugs against TB are needed.
Reinheimer, Claudia +5 more
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Visualization of a Covalent Intermediate between Microsomal Epoxide Hydrolase, but not Cholesterol Epoxide Hydrolase, and their Substrates [PDF]
European Journal of Biochemistry, 1997 Mammalian soluble and microsomal epoxide hydrolases have been proposed to belong to the family of αlβ‐hydrolase‐fold enzymes. These enzymes hydrolyse their substrates by a catalytic triad, with the first step of the enzymatic reaction being the formation of a covalent enzyme‐substrate ester. In the present paper, we describe the direct visualization of
Müller, F +10 more
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Microorganisms, 2021 Trichoderma hamatum FBL 587 isolated from DDT-contaminated agricultural soils stands out as a remarkable strain with DDT-resistance and the ability to enhance DDT degradation process in soil.
Domenico Davolos +8 more
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