Results 21 to 30 of about 43,844 (154)

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source

Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity

Data in Brief, 2016
The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira, Patricia Pereira Adriani, Flavia Garcia Borges, Adriana Rios Lopes, Patricia T. Campana, Felipe S. Chambergo   +5 more
doaj   +1 more source

Gene evolution of epoxide hydrolases and recommended nomenclature [PDF]

, 1995
We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase.
Shinozaki, K, Hammock, B D, Oesch, F, Kiyosue, T, Grant, D, Arand, Michael; https://orcid.org/, Beetham, J K, Pinot, F, Garbarino, J, Belknap, W R   +9 more
core   +1 more source

Representation of the created Multiple Sequence Alignment (MSA) of the epoxide hydrolases sequences.

, 2022
The red brace marks the sequences of the soluble epoxide hydrolases with known crystal structures. Gaps are marked in blue. MSA was pictured using the DECIPHER library for R (https://www.rdocumentation.org/packages/DECIPHER/versions/2.0.2). (TIFF)
Aleksandra Samol (12557801), Artur Góra (5400632), Karolina Mitusińska (5400629), Weronika Bagrowska (12557804), Tomasz Skalski (12557798), Agata Raczyńska (5632502), Maria Bzówka (5632499), Tomasz Magdziarz (1632316)   +7 more
core   +1 more source

Representation of the trimmed Multiple Sequence Alignment (MSA) of the epoxide hydrolases sequences.

, 2022
The red brace marks the sequences of the soluble epoxide hydrolases with known crystal structures. Gaps are marked in blue. MSA was pictured using the DECIPHER library for R (https://www.rdocumentation.org/packages/DECIPHER/versions/2.0.2). (TIFF)
Aleksandra Samol (12557801), Artur Góra (5400632), Karolina Mitusińska (5400629), Weronika Bagrowska (12557804), Tomasz Skalski (12557798), Agata Raczyńska (5632502), Maria Bzówka (5632499), Tomasz Magdziarz (1632316)   +7 more
core   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis [PDF]

, 2006
Epoxide hydrolases play an important role in the biodegradation of organic compounds and are potentially useful in enantioselective biocatalysis. An analysis of various genomic databases revealed that about 20% of sequenced organisms contain one or more ...
Janssen, D.B., Kingma, Jaap, Wubbolts, Marcel G, Wubbolts, Marcel, Arand, Michael; https://orcid.org/, Janssen, Dick B, van Loo, Bert, Kingma, J, van Loo, B, Arand, M., Wubbolts, Marcel G., Janssen, Dick B., Arand, Michael   +12 more
core   +1 more source

The role of soluble epoxide hydrolase and its inhibitors in depression

Brain, Behavior, & Immunity - Health, 2021
Evidence suggests that around 30 ​% of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
doaj   +1 more source

Detoxication Strategy of Epoxide Hydrolase—The Basis for a Novel Threshold for Definable Genotoxic Carcinogens

Dose-Response, 2004
From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed.
Franz Oesch, Jan Georg Hengstler, Michael Arand   +2 more
doaj   +1 more source

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source