Results 1 to 10 of about 11,525 (162)
Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac [PDF]
MoleculesBackground: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare +5 more
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Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism [PDF]
Scientific ReportsHepatic clearance is crucial as it directly impacts drug exposure, efficacy, and safety. Cytochrome P450 (CYP450) enzymes play a pivotal role in drug metabolism and exhibit differences based on sex, species, and commercial liver microsome vendors.
Nivedita Kinatukara, Xin Xu, Pranav Shah
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Frontiers in Chemistry, 2019 In this study, the metabolic profiles of a new illicit drug AMB-FUBINACA were investigated using both human liver microsome and zebrafish models. Liquid chromatography Q Extractive HF Hybrid Quadrupole-Orbitrap mass spectrometry (LC-QE-HF-MS) was ...
Duo-qi Xu +5 more
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Microsome Isolation from Tissue
Bio-Protocol, 2014 This protocol details the extraction of microsomes from frozen tissue in order to further examine the protein-protein interactions occurring within the endoplasmic reticulum. This protocol was adapted from Abisambra et al.
Maria Bodero, Jose Abisambra
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Investigating the potential role of metabolic resistance genes in conferring cross-resistance to pyrethroids and polycyclic aromatic hydrocarbon pollutants in the major malaria vector Anopheles coluzzii [PDF]
BMC GenomicsBackground Polycyclic aromatic hydrocarbons (PAHs) are a class of ubiquitous and recalcitrant environmental pollutants generated from petroleum activities and/or biological conversion of organic materials.
Abdullahi Muhammad +5 more
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Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay [PDF]
BMC Pharmacology and ToxicologyIntroduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis.
Yazun Jarrar +6 more
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Microbiology Spectrum, 2023 New antibacterial agents and agent combinations are urgently needed to combat antimicrobial resistance. A multidimensional chemical library screening strategy was used to identify compounds in the National Cancer Institute (NCI) diversity set V library ...
Shivani Gargvanshi +3 more
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Frontiers in Pharmacology, 2022 Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs.
Fang-Ling Zhao +13 more
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Microbiology Spectrum, 2022 Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a recent study, a library screening strategy was developed in which an FDA-approved drug library was screened against ...
Shivani Gargvanshi, William G. Gutheil
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Liver kidney microsome antibodies. Analysis of a laboratory series
Practical Laboratory Medicine, 2023 Objectives: The objectives were to characterize the liver kidney microsome (LKM) antibody profile of a 14-month-old girl with autoimmune hepatitis and analyze the laboratory prevalence of LKM positivity. Design and methods: This is retrospective analysis
Sandra Sanchez +6 more
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