Results 21 to 30 of about 11,599 (234)
The Journal of Cell Biology, 1956 The pancreatic exocrine cell of the guinea pig has a voluminous endoplasmic reticulum distinguished by extensive association with small, dense particles, and by its orderly disposition in the basal region of the cell. In addition to the small, (∼15 mµ), dense particles attached to the limiting membrane of the endoplasmic reticulum ...
G. E. Palade, P. Siekevitz
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NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
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Cells, 2022 The characterization of novel radiotracers toward their metabolic stability is an essential part of their development. While in vitro methods such as liver microsome assays or ex vivo blood or tissue samples provide information on overall stability ...
Sandy Lemm +6 more
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Hepatology, EarlyView., 2022 The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol +22 more
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The Journal of Cell Biology, 1956 Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO4-fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically identical with the rough surfaced elements of the endoplasmic reticula of hepatic ...
G. E. Palade, P. Siekevitz
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Bio-Protocol, 2017 The plant endomembrane system plays vital roles for synthesis, modification and secretion of proteins and lipids. From the classic view, only mRNAs encoding secreted proteins could be targeted to the endoplasmic reticulum (ER) for translation via a co ...
Yonghui Zhao, Shengben Li
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Stem Microsome Preparation and Mannan Synthase Activity Assay
Bio-Protocol, 2013 Mannans are hemicellulosic polysaccharides and are present in cell walls of all land plants. Mannan polysaccharides are synthesized by two enzymes, mannan synthase (ManS) for backbone (mannan or glucomannan) synthesis and galactomannan galactosyl ...
Yan Wang
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Evaluation the inhibitory effect of nicardipine on the metabolism of quetiapine
Frontiers in PharmacologyThe aim of this study was to investigate the impact of calcium channel blockers (CCBs) and antihypertensive traditional Chinese medicine (TCM) on the metabolism of quetiapine. In vitro, two incubation systems of rat liver microsomes (RLM) and human liver
Jinzhao Yang +5 more
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Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
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Effects of Kaempferia galanga L. and ethyl-p-methoxycinnamate (EPMC) [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2011 Kaempferia galanga L. (K. galanga L.), belonging to the Zingiberaceae family, has been widely used in Thai traditionalmedicine for treatment of hypertension, asthma, rheumatism, indigestion, cold and headache and relief abdominal pain.This study aimed to
Wanna Sirisangtragul +1 more
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