Results 31 to 40 of about 43,844 (154)

Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease [PDF]

, 2010
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered reno-protective.
Geisslinger, Gerd, Gerd Geisslinger, Tsai, Cindy, Ralf P. Brandes, Brandes, Ralf, Schäfer, Liliana, Amann Kerstin, Liliana Schaefer, Kerstin Amann, Felix Jansen, Jung, Oliver, Ralf P Brandes, Mieth Anja, Hwang Sung H., Schaefer Liliana, Anja Mieth, Hwang, Sung H., Barbosa-Sicard Eduardo, Sung H. Hwang, Bruce D. Hammock, Hammock Bruce D., Christophe Morisseau, Cindy Tsai, Rainer U. Pliquett, Oliver Jung, Brandes Ralf P., Pliquett Rainer U., Mieth, Anja, Babelova, Andrea, Barbosa Sicard, Eduardo, Geisslinger Gerd, Jansen, Felix, Andrea Babelova, Sung H Hwang, Morisseau, Christophe, Pliquett, Rainer U., Eduardo Barbosa-Sicard, Jung Oliver, Rainer U Pliquett, Bruce D Hammock, Jansen Felix, Tsai Cindy, Morisseau Christophe, Amann, Kerstin, Hammock, Bruce D., Babelova Andrea   +45 more
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Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?

Molecules, 2015
Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions.
Isabel Bordes, José Recatalá, Katarzyna Świderek, Vicent Moliner   +3 more
doaj   +1 more source

The database of epoxide hydrolases and haloalkane dehalogenases: one structure, many functions [PDF]

, 2015
The epoxide hydrolases and haloalkane dehalogenase database (EH/HD) integrates sequence and structure of a highly diverse protein family including mainly the Asp-hydrolases of EHs and HDs but also proteins like the Ser-hydrolases non-heme peroxidases ...
Barth, Sandra, Schmid, Rolf D., Fischer, Markus, Pleiss, Jürgen   +3 more
core   +1 more source

Anti-tubercular activity of a natural stilbene and its synthetic derivatives

GMS Infectious Diseases, 2018
Objectives: Tuberculosis (TB) and multidrug- and extensively drug-resistant TB in particular are remaining a major global health challenge and efficient new drugs against TB are needed.
Reinheimer, Claudia, Büttner, Dominik, Proschak, Eugen, Bode, Helge B., Kempf, Volkhard A. J., Wichelhaus, Thomas A.   +5 more
doaj   +1 more source

Epoxide hydrolases: structure, function, mechanism, and assay

, 2005
Epoxide hydrolases are a class of enzymes important in the detoxification of genotoxic compounds, as well as in the control of physiological signaling molecules.
Adamska, Magdalena, Oesch, Franz, Arand, Michael; https://orcid.org/, Cronin, Annette, Annette Cronin, Magdalena Adamska, Michael Arand, Franz Oesch   +7 more
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A Genomic and Transcriptomic Study on the DDT-Resistant Trichoderma hamatum FBL 587: First Genetic Data into Mycoremediation Strategies for DDT-Polluted Sites

Microorganisms, 2021
Trichoderma hamatum FBL 587 isolated from DDT-contaminated agricultural soils stands out as a remarkable strain with DDT-resistance and the ability to enhance DDT degradation process in soil.
Domenico Davolos, Fabiana Russo, Loredana Canfora, Eligio Malusà, Małgorzata Tartanus, Ewa Maria Furmanczyk, Andrea Ceci, Oriana Maggi, Anna Maria Persiani   +8 more
doaj   +1 more source

Promiscuous Dehalogenase Activity of the Epoxide Hydrolase CorEH from Corynebacterium sp. C12 [PDF]

, 2021
Haloalkane dehalogenases and epoxide hydrolases are phylogenetically related and structurally homologous enzymes that use nucleophilic aspartate residues for an SN2 attack on their substrates.
Bornscheuer, Uwe T. (Prof. Dr.), Berndt, Leona, Mican, Jan, Damborsky, Jiri, Schuiten, Eva D., Lammers, Michael, Bednar, David, Badenhorst, Christoffel P.S., Palm, Gottfried J., Lammers, M., Damborsky, J., Mican, J., Bednar, D., Badenhorst, C.P.S., Palm, G.J., Bornscheuer, U.T., Schuiten, E.D., Berndt, L., Eva D. Schuiten, Gottfried J. Palm, Christoffel P. S. Badenhorst, Jiri Damborsky, Leona Berndt, David Bednar, Uwe T. Bornscheuer, Jan Mican, Michael Lammers   +26 more
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Transcriptomic analyses reveal increased expression of dioxygenases, monooxygenases, and other metabolizing enzymes involved in anthracene degradation in the marine alga Ulva lactuca

Frontiers in Plant Science, 2022
To analyze the mechanisms involved in anthracene (ANT) degradation in the marine alga Ulva lactuca, total RNA was obtained from the alga cultivated without ANT and with 5 μM of ANT for 24 h, and transcriptomic analyses were performed.
Alberto González, Héctor Osorio, Stephanie Romero, Patricia Méndez, Muriel Sepúlveda, Daniel Laporte, Marlen Gutierrez-Cutiño, Rocío Santander, Eduardo Castro-Nallar, Eduardo Castro-Nallar, Alejandra Moenne   +10 more
doaj   +1 more source

Compositional profile of α / β-hydrolase fold proteins in mangrove soil metagenomes: prevalence of epoxide hydrolases and haloalkane dehalogenases in oil-contaminated sites. [PDF]

Microb Biotechnol, 2015
The occurrence of genes encoding biotechnologically relevant α/β-hydrolases in mangrove soil microbial communities was assessed using data obtained by whole-metagenome sequencing of four mangroves areas, denoted BrMgv01 to BrMgv04, in São Paulo, Brazil ...
Jiménez DJ, Dini-Andreote F, Ottoni JR, de Oliveira VM, van Elsas JD, Andreote FD.   +5 more
europepmc   +2 more sources

Cloning and application of epoxide hydrolases from yeasts [PDF]

, 2002
Epoxides are cyclic ethers that readily react with various nucleophilic compounds. Consequently, epoxides can be used in many chemical synthesis reactions. Two enantiomeric forms of an epoxide are possible if one of the carbon atoms is chiral. This means
Visser, J.H.
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