Results 31 to 40 of about 3,719 (161)
Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity
Data in Brief, 2016 The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira +5 more
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Epoxide Hydrolase Family: Biological Functions, Disease Mechanisms, and Emerging Therapeutic Strategies. [PDF]
Biology (Basel)Epoxide hydrolases (EHs) constitute a conserved enzyme family that catalyzes the hydrolysis of epoxides into less reactive diols. Beyond their canonical roles in xenobiotic detoxification, EHs have emerged as critical regulators of lipid metabolism ...
Tan Y +6 more
europepmc +2 more sources
Angewandte Chemie, EarlyView.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
The role of soluble epoxide hydrolase and its inhibitors in depression
Brain, Behavior, & Immunity - Health, 2021 Evidence suggests that around 30 % of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
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Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Dose-Response, 2004 From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed.
Franz Oesch +2 more
doaj +1 more source
Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.
PLoS ONE, 2017 Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes +8 more
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Visualization of a Covalent Intermediate between Microsomal Epoxide Hydrolase, but not Cholesterol Epoxide Hydrolase, and their Substrates [PDF]
European Journal of Biochemistry, 1997 Mammalian soluble and microsomal epoxide hydrolases have been proposed to belong to the family of αlβ‐hydrolase‐fold enzymes. These enzymes hydrolyse their substrates by a catalytic triad, with the first step of the enzymatic reaction being the formation of a covalent enzyme‐substrate ester. In the present paper, we describe the direct visualization of
Müller, F +10 more
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Is Promiscuous CALB a Good Scaffold for Designing New Epoxidases?
Molecules, 2015 Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions.
Isabel Bordes +3 more
doaj +1 more source
Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]
Physiological Reviews, 2012 Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
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