Results 31 to 40 of about 128,828 (279)

Discovery and characterization of thermophilic limonene‐1,2‐epoxide hydrolases from hot spring metagenomic libraries

FEBS Journal, 2015
The epoxide hydrolases (EHs) represent an attractive option for the synthesis of chiral epoxides and 1,2‐diols which are valuable building blocks for the synthesis of several pharmaceutical compounds.
E. Ferrandi, C. Sayer, M. Isupov, Celeste Annovazzi, C. Marchesi, G. Iacobone, Xu Peng, E. Bonch‐Osmolovskaya, Roland Wohlgemuth, J. Littlechild, D. Monti   +10 more
semanticscholar   +3 more sources

Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases [PDF]

mBio, 2017
Michael Arand, Anne Marowsky
doaj   +2 more sources

Reply to “Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases” [PDF]

mBio, 2017
Daniel E. Goldberg, Natalie J. Spillman
doaj   +2 more sources

Corrigendum to “Structure–function relationship between soluble epoxide hydrolases structure and their tunnel network” [Comput. Struct. Biotechnol. J. 20 (2022) 193–205] [PDF]

Computational and Structural Biotechnology Journal, 2022
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra   +7 more
doaj   +2 more sources

The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain. [PDF]

Drug Metab Dispos, 2015
Kodani SD, Hammock BD.
europepmc   +2 more sources

Computational Design of Enantiocomplementary Epoxide Hydrolases for Asymmetric Synthesis of Aliphatic and Aromatic Diols. [PDF]

Chembiochem, 2020
Arabnejad H, Bombino E, Colpa DI, Jekel PA, Trajkovic M, Wijma HJ, Janssen DB.   +6 more
europepmc   +3 more sources

Understanding Complex Mechanisms of Enzyme Reactivity: The Case of Limonene-1,2-Epoxide Hydrolases

ACS Catalysis, 2018
Silvia Rinaldi, M. Kamp, K. Ranaghan, A. Mulholland, G. Colombo   +4 more
semanticscholar   +3 more sources

11,12-EET stimulates the association of BK channel α and β(1) subunits in mitochondria to induce pulmonary vasoconstriction [PDF]

, 2012
In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca2+-activated potassium (BK) channels. However, in
Daiber, Andreas, Fleming, Ingrid, Keserü, Benjamin, Loot, Annemarieke E., Moneke, Isabelle, Oelze, Matthias, Syzonenko, Tetyana   +6 more
core   +8 more sources

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

eLife, 2021
Epoxide hydrolases (EHs) regulate cellular homeostasis through hydrolysis of epoxides to less-reactive diols. The first discovered EH was EPHX1, also known as mEH.
Jeremie Gautheron, Christophe Morisseau, Wendy K Chung, Jamila Zammouri, Martine Auclair, Genevieve Baujat, Emilie Capel, Celia Moulin, Yuxin Wang, Jun Yang, Bruce D Hammock, Barbara Cerame, Franck Phan, Bruno Fève, Corinne Vigouroux, Fabrizio Andreelli, Isabelle Jeru   +16 more
doaj   +1 more source

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source