Results 51 to 60 of about 3,732 (161)

Improving Hydrolytic Activity and Enantioselectivity of Epoxide Hydrolase from Phanerochaete chrysosporium by Directed Evolution

Molecules
Epoxide hydrolases (EHs) catalyze the conversion of epoxides into vicinal diols. The epoxide hydrolase gene from P. chrysosporium was previously cloned and subjected to site-directed mutation to study its enzyme activity, but the results were ...
Huanhuan Shao, Pan Xu, Xiang Tao, Xinyi He, Chunyan Pu, Shaorong Liang, Yingxin Shi, Xiaoyan Wang, Hong Feng, Bin Yong   +9 more
doaj   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Applications and limitations of AI tools in enzyme design

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Enzymes catalyze various different chemical reactions often with high efficiency and selectivity compared to synthetic catalysts. Advances in protein engineering over the past decades have allowed researchers to design enzymes, improving their catalytic performance and adapting them for specific or entirely novel chemical reactions.
Rosa Teijeiro‐Juiz, Nina Egeler, Grzegorz Jamróg, Marion Ringel, Thomas Brück, Bruno Di Geronimo, Bernhard Loll   +6 more
wiley   +1 more source

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]

Journal of Biological Chemistry, 2013
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson, Rishi M, Subrahmanyan, Sol A, Summers, Xiangshu, Xiao, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Crystal structure of endo‐β‐1,6‐galactanase from Streptomyces avermitilis

Acta Crystallographica Section D, Volume 82, Issue 8, Page 962-971, August 2026.
The crystal structure of S. avermitilis endo‐β‐1,6‐galactanase belonging to GH30 subfamily 5 reveals the first structural framework for endo‐β‐1,6‐galactanase. The β‐1,6‐galactobiose‐bound complex identifies the catalytic subsites and a distal secondary sugar‐binding site, providing insight into β‐1,6‐galactan recognition.Endo‐β‐1,6‐galactanases ...
Zui Fujimoto, Naomi Kishine, Toshihisa Kotake, Satoshi Kaneko   +3 more
wiley   +1 more source

Regulation Roles of Juvenile Hormone Epoxide Hydrolase Gene 2 in the Female River Prawn Macrobrachium nipponense Reproductive Process

Current Issues in Molecular Biology
In this study, we investigated the regulatory roles of the juvenile hormone epoxide hydrolase (JHEH) gene in the reproductive process of female Macrobrachium nipponense. Its total cDNA length was 1848 bp, encoding for 460 amino acids.
Jisheng Wang, Mengying Zhang, Hongtuo Fu, Wenyi Zhang, Yiwei Xiong, Shubo Jin, Hui Qiao, Sufei Jiang   +7 more
doaj   +1 more source

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source

Enzymes from Extreme Environments and their Industrial Applications

Frontiers in Bioengineering and Biotechnology, 2015
This article will discuss the importance of specific extremophilic enzymes for applications in industrial biotechnology. It will specifically address those enzymes that have applications in the area of biocatalysis.
Jennifer Ann Littlechild
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, Volume 16, Issue 7, Page 1328-1339, July 2026.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source