Results 61 to 70 of about 3,732 (161)

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

New High-Throughput Screening Assays for Biocatalysis

CHIMIA, 2001
High-throughput screening for catalysis is a critical technology in all experiments aimed at modifying or creating enzymes by directed evolution, as well as for biodiversity mining for new catalysts.
Jean-Louis Reymond
doaj   +2 more sources

Co‐Detoxification of Multiple Mycotoxins: Microbial and Enzymatic Biodegradation Processes

Food Frontiers, Volume 7, Issue 4, July 2026.
The presence of mycotoxins poses a threat to food safety. This article reviews microbial/enzymatic detoxification technologies and the main degradation pathways of key mycotoxins. We propose to overcome current bottlenecks through enzyme engineering and synthetic biology, providing a roadmap for sustainable and scalable solutions.
Lixia Fan, Changying Guo, Saranya Poapolathep, Amnart Poapolathep, Mingxiao Ning, Bingchun Zhang, Xianfeng Ren, Antonio F. Logrieco   +7 more
wiley   +1 more source

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Optimization of translation profiles enhances protein expression and solubility.

PLoS ONE, 2015
mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to ...
Anne-Katrin Hess, Paul Saffert, Klaus Liebeton, Zoya Ignatova   +3 more
doaj   +1 more source

epoxide hydrolase

Citation: 'epoxide hydrolase' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10676 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

Frontiers in Pharmacology, 2019
Inflammation plays a key role in the pathogenesis of a number of psychiatric and neurological disorders. Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the ...
Kenji Hashimoto
doaj   +1 more source

Drawing Links from Transcriptome to Metabolites: The Evolution of Aroma in the Ripening Berry of Moscato Bianco (Vitis vinifera L.)

Frontiers in Plant Science, 2017
Monoterpenes confer typical floral notes to “Muscat” grapevine varieties and, to a lesser extent, to other aromatic non-Muscat varieties. Previous studies have led to the identification and functional characterization of some enzymes and genes in this ...
Laura Costantini, Christian D. Kappel, Massimiliano Trenti, Juri Battilana, Francesco Emanuelli, Maddalena Sordo, Marco Moretto, Céline Camps, Roberto Larcher, Serge Delrot, Maria S. Grando, Maria S. Grando   +11 more
doaj   +1 more source

Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening

CHIMIA
Serine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation.
Franciscus H. G. ter Brake, Patrick Rehorst, Machiel W. Henst, Mario van der Stelt, Antonius P. A. Janssen   +4 more
doaj   +1 more source

P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins

Journal of Lipid Research
Oxylipins—oxidized metabolites of polyunsaturated fatty acids (PUFAs)—are associated with several pathological conditions. We previously showed that oxylipin metabolites of linoleic acid (LA) and alpha-linolenic acid positively correlate with obesity in ...
Poonamjot Deol, Johannes Fahrmann, Dmitry Grapov, Jun Yang, Jane R. Evans, Oliver Fiehn, Brett Phinney, Bruce D. Hammock, Frances M. Sladek   +8 more
doaj   +1 more source