Results 61 to 70 of about 3,719 (161)
Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]
Journal of Biological Chemistry, 2013 Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson +4 more
openaire +2 more sources
MoleculesEpoxide hydrolases (EHs) catalyze the conversion of epoxides into vicinal diols. The epoxide hydrolase gene from P. chrysosporium was previously cloned and subjected to site-directed mutation to study its enzyme activity, but the results were ...
Huanhuan Shao +9 more
doaj +1 more source
Current Issues in Molecular BiologyIn this study, we investigated the regulatory roles of the juvenile hormone epoxide hydrolase (JHEH) gene in the reproductive process of female Macrobrachium nipponense. Its total cDNA length was 1848 bp, encoding for 460 amino acids.
Jisheng Wang +7 more
doaj +1 more source
Enzymes from Extreme Environments and their Industrial Applications
Frontiers in Bioengineering and Biotechnology, 2015 This article will discuss the importance of specific extremophilic enzymes for applications in industrial biotechnology. It will specifically address those enzymes that have applications in the area of biocatalysis.
Jennifer Ann Littlechild
doaj +1 more source
New High-Throughput Screening Assays for Biocatalysis
CHIMIA, 2001 High-throughput screening for catalysis is a critical technology in all experiments aimed at modifying or creating enzymes by directed evolution, as well as for biodiversity mining for new catalysts.
Jean-Louis Reymond
doaj +2 more sources
Optimization of translation profiles enhances protein expression and solubility.
PLoS ONE, 2015 mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to ...
Anne-Katrin Hess +3 more
doaj +1 more source
Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders
Frontiers in Pharmacology, 2019 Inflammation plays a key role in the pathogenesis of a number of psychiatric and neurological disorders. Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the ...
Kenji Hashimoto
doaj +1 more source
Frontiers in Plant Science, 2017 Monoterpenes confer typical floral notes to “Muscat” grapevine varieties and, to a lesser extent, to other aromatic non-Muscat varieties. Previous studies have led to the identification and functional characterization of some enzymes and genes in this ...
Laura Costantini +11 more
doaj +1 more source
Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening
CHIMIASerine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation.
Franciscus H. G. ter Brake +4 more
doaj +1 more source
Dihydroxy fatty acids can be used for screening autism traits in toddlers
Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Takaharu Hirai +7 more
wiley +1 more source