Results 81 to 90 of about 128,828 (279)

Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking

Biomolecules, 2018
Several different approaches are used to describe the role of protein compartments and residues in catalysis and to identify key residues suitable for the modification of the activity or selectivity of the desired enzyme.
Karolina Mitusińska, Tomasz Magdziarz, Maria Bzówka, Agnieszka Stańczak, Artur Góra   +4 more
doaj   +1 more source

Detoxification Strategy of Epoxide Hydrolase [PDF]

, 2003
The human microsomal epoxide hydrolase, a single enzyme, has to detoxify a broad range of structurally diverse, potentially genotoxic epoxides that are formed in the course of xenobiotic metabolism. The enzyme has developed a unique strategy to combine a
Arand, Michael, Cronin, Annette, Hengstler, Jan G., Herrero Plana, Maria Elena, Lohmann, Matthias, Oesch, Franz   +5 more
core  

Cholesterol epoxide hydrolase and cancer

Current Opinion in Pharmacology, 2012
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol. ChEH is a hetero-oligomeric complex called the anti-estrogen binding site (AEBS) comprising 3β-hydroxysterol-Δ(8)-Δ(7)-isomerase (D8D7I) and 3β-hydroxysterol-Δ(7)-reductase (DHCR7).
Silvente-Poirot, Sandrine, Poirot, Marc
openaire   +3 more sources

PFAS properties and destruction methods: A focus on enzymatic degradation

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Per‐ and polyfluoroalkyl substances (PFAS) are known as ‘forever’ chemicals and have lasting detrimental impact on the environment and living organisms. To understand PFAS molecules better, this review begins with an overview of PFAS definition, classifications and applications, and then provides a comprehensive summary and critical analysis ...
Guobin Liang, Hua Zhao
wiley   +1 more source

1,6-Cyclophellitol Cyclosulfates : A New Class of Irreversible Glycosidase Inhibitor [PDF]

, 2017
The essential biological roles played by glycosidases, coupled to the diverse therapeutic benefits of pharmacologically targeting these enzymes, provide considerable motivation for the development of new inhibitor classes.
Aerts, Johannes M.F.G., Artola, Marta, Breen, Imogen Z., Codée, Jeroen D.C., Davies, Gideon J., Ferraz, Maria J., Kuo, Chi Lin, Offen, Wendy A., Overkleeft, Herman S., Raich, Lluís, Rovira, Carme, Van Der Marel, Gijsbert A., Wu, Liang   +12 more
core   +9 more sources

ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions [PDF]

, 2012
The ESTHER database, which is freely available via a web server (http://bioweb.ensam.inra.fr/esther) and is widely used, is dedicated to proteins with an a/b-hydrolase fold, and it currently contains >30 000 manually curated proteins.
Bourne, Yves, Chatonnet, Arnaud, Hotelier, Thierry, Lenfant, Nicolas, Marchot, P., Velluet, Eric   +5 more
core   +4 more sources

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
openaire   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Improving Hydrolytic Activity and Enantioselectivity of Epoxide Hydrolase from Phanerochaete chrysosporium by Directed Evolution

Molecules
Epoxide hydrolases (EHs) catalyze the conversion of epoxides into vicinal diols. The epoxide hydrolase gene from P. chrysosporium was previously cloned and subjected to site-directed mutation to study its enzyme activity, but the results were ...
Huanhuan Shao, Pan Xu, Xiang Tao, Xinyi He, Chunyan Pu, Shaorong Liang, Yingxin Shi, Xiaoyan Wang, Hong Feng, Bin Yong   +9 more
doaj   +1 more source

Catalysis of potato epoxide hydrolase, StEH1 [PDF]

Biochemical Journal, 2005
The kinetic mechanism of epoxide hydrolase (EC 3.3.2.3) from potato, StEH1 (Solanum tuberosum epoxide hydrolase 1), was studied by presteady-state and steady-state kinetics as well as by pH dependence of activity. The specific activities towards the different enantiomers of TSO (trans-stilbene oxide) as substrate were 43 and 3 μmol·min−1·mg−1 with the ...
Lisa T, Elfström, Mikael, Widersten
openaire   +2 more sources