Results 81 to 90 of about 43,844 (154)

Epoxide Hydrolase-Catalyzed Enantioselective Synthesis of Chiral 1,2-Diols via Desymmetrization of meso-Epoxides

, 2016
The discovery, from nature, of a diverse set of microbial epoxide hydrolases is reported. The utility of a library of epoxide hydrolases in the synthesis of chiral 1,2-diols via desymmetrization of a wide range of meso-epoxides, including cyclic as well ...
Mark Miller (134024), Zilin Huang (2708122), Dan E. Robertson (2708125), Zuolin Zhu (2689738), Lishan Zhao (2708134), Aileen Milan (2708131), Bin Han (45760), David P. Weiner (2431768), Hongjun Huang (2708119), Dan S. Malashock (2708128), Mark J. Burk (2677699)   +10 more
core   +1 more source

Optimization of translation profiles enhances protein expression and solubility.

PLoS ONE, 2015
mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. Using structure-based homology we identified the structural domains in epoxide hydrolases (EHs) and introduced slow-translating codons to ...
Anne-Katrin Hess, Paul Saffert, Klaus Liebeton, Zoya Ignatova   +3 more
doaj   +1 more source

Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases

, 2000
BACKGROUND Epoxide hydrolases have important roles in the defense of cells against potentially harmful epoxides. Conversion of epoxides into less toxic and more easily excreted diols is a universally successful strategy.
Oesch, F, Hallberg, B M, Mowbray, S L, Arand, Michael; https://orcid.org/, Zou, J, Jones, T A, Bergfors, T, T Alwyn Jones, Jinyu Zou, Franz Oesch, B Martin Hallberg, Terese Bergfors, Sherry L Mowbray, Michael Arand   +13 more
core   +1 more source

Exploitation of novel epoxide hydrolases from metagenomic libraries in the solvent-free preparative resolutions of limonene oxides mixtures

, 2016
Exploitation of novel epoxide hydrolases from metagenomic libraries in the solvent-free preparative resolutions of limonene oxides ...
D MONTI, E E Ferrandi, S Riva, R Wohlgemuth, C Marchesi, C Annovazzi   +5 more
core  

Role of Soluble Epoxide Hydrolase in Metabolism of PUFAs in Psychiatric and Neurological Disorders

Frontiers in Pharmacology, 2019
Inflammation plays a key role in the pathogenesis of a number of psychiatric and neurological disorders. Soluble epoxide hydrolases (sEH), enzymes present in all living organisms, metabolize epoxy fatty acids (EpFAs) to corresponding 1,2-diols by the ...
Kenji Hashimoto
doaj   +1 more source

Drawing Links from Transcriptome to Metabolites: The Evolution of Aroma in the Ripening Berry of Moscato Bianco (Vitis vinifera L.)

Frontiers in Plant Science, 2017
Monoterpenes confer typical floral notes to “Muscat” grapevine varieties and, to a lesser extent, to other aromatic non-Muscat varieties. Previous studies have led to the identification and functional characterization of some enzymes and genes in this ...
Laura Costantini, Christian D. Kappel, Massimiliano Trenti, Juri Battilana, Francesco Emanuelli, Maddalena Sordo, Marco Moretto, Céline Camps, Roberto Larcher, Serge Delrot, Maria S. Grando, Maria S. Grando   +11 more
doaj   +1 more source

Inactivation of epoxide hydrolase by catalysis-induced formation of isoaspartate [PDF]

, 2008
Epoxide hydrolases catalyze hydrolytic epoxide ring-opening, most often via formation of a covalent hydroxyalkyl-enzyme intermediate. A mutant of Agrobacterium radiobacter epoxide hydrolase, in which the phenylalanine residue that flanks the invariant ...
Kingma, Jaap, Permentier, Hjalmar P.; id_orcid, Janssen, Dick B., Baldascini, Helen, Permentier, Hjalmar P., van Loo, Bert   +5 more
core   +1 more source

Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening

CHIMIA
Serine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation.
Franciscus H. G. ter Brake, Patrick Rehorst, Machiel W. Henst, Mario van der Stelt, Antonius P. A. Janssen   +4 more
doaj   +1 more source

P2-HNF4α alters linoleic acid metabolism and mitigates soybean oil-induced obesity: role for oxylipins

Journal of Lipid Research
Oxylipins—oxidized metabolites of polyunsaturated fatty acids (PUFAs)—are associated with several pathological conditions. We previously showed that oxylipin metabolites of linoleic acid (LA) and alpha-linolenic acid positively correlate with obesity in ...
Poonamjot Deol, Johannes Fahrmann, Dmitry Grapov, Jun Yang, Jane R. Evans, Oliver Fiehn, Brett Phinney, Bruce D. Hammock, Frances M. Sladek   +8 more
doaj   +1 more source

Whole cell quick E for epoxide hydrolase screening using fluorescent probes

, 2008
We describe herein a modified quick E to access the enantioselectivity (E) of epoxide hydrolases using chiral fluorogenic probes.
Mantovani, Simone Moraes, Marsaioli, Anita Jocelyne, Gonzaga De Oliveira, Luciana   +2 more
core   +1 more source