Results 91 to 100 of about 43,844 (154)

Discovery and synthetic exploitation of novel epoxide hydrolases from hot springs metagenomes

, 2015
The presented work has been carried out within the framework of the HotZyme Project, an EU FP7 Collaborative programme that aims to exploit a metagenomic approach in diverse hot environments to identify new thermostable hydrolases with improved ...
Daniela Monti
core  

Quantitative Structure−Activity Relationships for the Enantioselectivity of Oxirane Ring-Opening Catalyzed by Epoxide Hydrolases

, 2019
The enantioselective ring-opening catalyzed by epoxide hydrolases originating from seven different sources of a series of 2,2-disubstituted oxiranes containing alkyl chains of different lengths, unsaturated (alkenyl, alkinyl) and aromatic groups as well ...
Andreas Steinreiber (3031518), Walter M. F. Fabian (1852501), Joachim A. Paier (6549197), Simona Funar-Timofei (6549194), Kurt Faber (1279671), Takahiro Suzuki (88656)   +5 more
core   +1 more source

Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. [PDF]

Int J Mol Sci, 2021
Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KSS, Hammock BD.   +5 more
europepmc   +1 more source

Allosteric Regulation of Epoxide Opening Cascades by a Pair of Epoxide Hydrolases in Monensin Biosynthesis

, 2016
Multistep catalysis of epoxide hydrolase/cyclase in the epoxide opening cascade is an intriguing issue in polyether biosynthesis. A pair of structurally homologous epoxide hydrolases was found in gene clusters of ionophore polyethers.
Azusa Oikawa (1843063), Toyoyuki Ose (513816), Hideaki Oikawa (822472), Atsushi Minami (822471), Hiroki Oguri (1843054), Katsumi Maenaka (457393), Kyohei Sato (1843060), Kimiko Kuroki (1843057)   +7 more
core   +1 more source

Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function

, 2005
Epoxide hydrolases are vital to many organisms by virtue of their roles in detoxification, metabolism and processing of signaling molecules. The Mycobacterium tuberculosis genome encodes an unusually large number of epoxide hydrolases, suggesting that ...
Jones, T Alwyn, Unge, Torsten, Arand, Michael; https://orcid.org/, Cronin, Annette, Johansson, Patrik, Mowbray, Sherry L, Bergfors, Terese, Jones, T. Alwyn, Mowbray, Sherry, Arand, Michael, Cronin, Anette   +10 more
core   +1 more source

Epoxide Hydrolase–Lasalocid A Structure Provides Mechanistic Insight into Polyether Natural Product Biosynthesis

, 2016
Biosynthesis of some polyether natural products involves a kinetically disfavored epoxide-opening cyclic ether formation, a reaction termed anti-Baldwin cyclization.
Kenji Watanabe (75040), Fong T. Wong (1689868), Minyi Fang (1689862), Chu-Young Kim (1689865), Xi Chen (35903), Kinya Hotta (550163)   +5 more
core   +1 more source

Advances in the Degradation of Polycyclic Aromatic Hydrocarbons by Yeasts: A Review

Microorganisms
Polycyclic aromatic hydrocarbons (PAHs) are toxic organic compounds produced during the incomplete combustion of organic materials and are commonly found in the environment due to anthropogenic activities such as industrial and vehicular emissions as ...
Francisco Padilla-Garfias, Minerva Araiza-Villanueva, Martha Calahorra, Norma Silvia Sánchez, Antonio Peña   +4 more
doaj   +1 more source

Structure-function relationships of epoxide hydrolases and their potential use in biocatalysis

, 2010
BACKGROUND: Chiral epoxides and diols are important synthons for manufacturing fine chemicals and pharmaceuticals. The epoxide hydrolases (EC 3.3.2.-) catalyze the hydrolytic ring opening of epoxides producing the corresponding vicinal diol.
Gurell, Ann,, Lindberg, Diana,, Widersten, Mikael,   +2 more
core   +1 more source

The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease. [PDF]

Int J Mol Sci, 2020
Gautheron J, Jéru I.
europepmc   +1 more source

Prospecting for efficient enantioselective epoxide hydrolases

, 2011
161-177Epoxide hydrolases (EHs) from microbial sources have recently been recognized as a versatile biocatalytic tool for the synthesis of enantiomerically pure epoxides and vicinal diols.
Sareen, Dipti, Kumar, Ranjai
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