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α/β Hydrolases: Toward Unraveling Entangled Classification. [PDF]

Proteins
Ozhelvaci F, Steczkiewicz K.
europepmc   +1 more source

Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids. [PDF]

J Biol Chem
Edin ML, Graves JP, Zeldin DC.
europepmc   +1 more source

Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway. [PDF]

Chin Med J (Engl)
Cai Y, Hu S, Liu J, Luo J, Li W, Tang J, Liu S, Dong R, Yang Y, Tu L, Xu X.   +10 more
europepmc   +1 more source

Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

Conte M, Qiu Q, Carmona OG, Abis G, Fraternali F.   +4 more
europepmc   +1 more source

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Synthetic applications of epoxide hydrolases

Current Opinion in Chemical Biology, 2001
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation ...
Alain Archelas, Roland Furstoss
exaly   +3 more sources

Cytosolic epoxide hydrolase

Chemico-Biological Interactions, 1988
Epoxide hydrolase activity is recovered in the high-speed supernatant fraction from the liver of all mammals so far examined, including man. For some as yet unexplained reason, the rat has a very low level of this activity, so that cytosolic epoxide hydrolase is generally studied in mice.
J, Meijer, J W, DePierre
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The Telltale Structures of Epoxide Hydrolases

Drug Metabolism Reviews, 2003
Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds.
Arand, Michael, Cronin, Annette, Oesch, Franz, Mowbray, Sherry L, Jones, T Alwyn   +4 more
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The interaction of cytosolic epoxide hydrolase with chiral epoxides

International Journal of Biochemistry, 1993
1. The kinetic parameters of the cytosolic epoxide hydrolase were examined with two sets of spectrophotometric substrates. The (2S,3S)- and (2R,3R)-enantiomers of 4-nitrophenyl trans-2,3-epoxy-3-phenylpropyl carbonate had a KM of 33 and 68 microns and a Vmax of 16 and 27 mumol/min/mg, respectively.
E C, Dietze, E, Kuwano, B D, Hammock
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Stereoselectivities of microbial epoxide hydrolases

Current Opinion in Chemical Biology, 1999
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the corresponding enantiomerically enriched vicinal diol and the remaining nonconverted epoxide, enantioconvergent processes are also possible, which lead to ...
R V, Orru, K, Faber
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Converting an Esterase into an Epoxide Hydrolase

Angewandte Chemie International Edition, 2009
AbstractEntering the fold: A common structural motif in hydrolytic enzymes is the α,β‐hydrolase fold. The interconversion of one enzyme into another by introduction of mechanistically important residues is not enough; only substitution of a loop allows epoxide hydrolase activity in the esterase scaffold to be formed (see picture; structure comparison ...
Helge, Jochens, Konstanze, Stiba, Christopher, Savile, Ryota, Fujii, Juin-Guo, Yu, Tatsiana, Gerassenkov, Romas J, Kazlauskas, Uwe T, Bornscheuer   +7 more
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