Results 121 to 130 of about 3,719 (161)
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Membrane topology of epoxide hydrolase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990The amino acid sequences of epoxide hydrolase from rat, rabbit and human have been subjected to hydropathy analysis and a novel model for the membrane topology of this enzyme is presented. The enzyme would appear to be retained in microsomal membranes by a single transmembrane segment located at the N-terminus and the majority (96%) of the protein is ...
J A, Craft +3 more
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Biochemical and Biophysical Research Communications, 1996
We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
H, Wojtasek, G D, Prestwich
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We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
H, Wojtasek, G D, Prestwich
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Epoxide Hydrolases and Their Synthetic Applications
1999Chiral epoxides and 1,2-diols, which are central building blocks for the asymmetric synthesis of bioactive compounds, can be obtained by using enzymes--i.e. epoxide hydrolases--which catalyse the enantioselective hydrolysis of epoxides. These biocatalysis have recently been found to be more widely distributed in fungi and bacteria than previously ...
R V, Orru +3 more
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Rat Cytosolic Epoxide Hydrolase
1986Rat liver microsomal and cytosolic epoxide hydrolase may be distinguished through differences in substrate specificity: styrene 7,8-oxide is preferentially hydrolyzed by the microsomal form, while trans-stilbene oxide is the preferred substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of Sprague-Dawley
F, Oesch +4 more
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2018
Epoxide hydrolases (EHs) metabolize highly reactive epoxides with mutagenic and carcinogenic potential to the less reactive corresponding diols and are therefore traditionally viewed as detoxicating enzymes. In few instances, however, the diols themselves can be precursors of further reactive metabolites, and EH may thereby contribute to metabolic ...
Arand, Michael, Marowsky, Anne
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Epoxide hydrolases (EHs) metabolize highly reactive epoxides with mutagenic and carcinogenic potential to the less reactive corresponding diols and are therefore traditionally viewed as detoxicating enzymes. In few instances, however, the diols themselves can be precursors of further reactive metabolites, and EH may thereby contribute to metabolic ...
Arand, Michael, Marowsky, Anne
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Enantioselectivities of yeast epoxide hydrolases for 1,2-epoxides
Tetrahedron: Asymmetry, 1999Abstract Kinetic resolution of homologous series of unbranched 1,2-epoxyalkanes (C-4 to C-12), 1,2-epoxyalkenes (C-4, C-6 and C-8), a 2,2-dialkylsubstituted epoxide (2-methyl-1,2-epoxyheptane) and a benzyloxy-substituted epoxide (benzyl glycidyl ether) was investigated using resting cells of 10 different yeast strains.
Botes, A.L. +3 more
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Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity
Biochemical and Biophysical Research Communications, 1990Purified leukotriene A4 hydrolase from human leukocytes is shown to exhibit peptidase activity towards the synthetic substrates alanine-4-nitroanilide and leucine-4-nitroanilide. The enzymatic activity is abolished after heat treatment (70 degrees C, 30 min).
J Z, Haeggström +3 more
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Toxicology Letters, 1986
The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase. Investigations were carried out regarding the formation of reactive epoxide intermediates and their different interactions with the hepatic epoxide hydrolase.
D. Cova +3 more
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The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase. Investigations were carried out regarding the formation of reactive epoxide intermediates and their different interactions with the hepatic epoxide hydrolase.
D. Cova +3 more
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Inactivation of a Diol Epoxide by Dihydrodiol Dehydrogenase But Not by Two Epoxide Hydrolases
Science, 1982The mutagenicity of r -8, t -9-dihydroxy- t -10, 11-oxy-8,9,10,11-tetrahydrobenz[ a ]anthracene (BA-8,9-diol 10,11-oxide) toward Salmonella typhimurium TA 100 is not decreased by the presence of large amounts of highly ...
H R, Glatt +9 more
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Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase
Lipids, 1981AbstractThe isolation and measurement of phospholipid epoxides as major peroxidation products in biomembrane preparations prompted an investigation of enzymatic mechanisms which may be responsible for their elimination. Analysis of microsomal epoxide hydrolase and phospholipase A2 activity against a phospholipid epoxide commonly encountered in tissues ...
A, Sevanian, R A, Stein, J F, Mead
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