Results 121 to 130 of about 3,732 (161)
Some of the next articles are maybe not open access.
Improvement of the Epoxide Hydrolase Properties for the Enantioselective Hydrolysis of Epoxides
Current Organic Chemistry, 2013Peer ...
Solares, L. F., Mateo González, César
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1996
We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
Hubert Wojtasek, Glenn D. Prestwich
openaire +2 more sources
We describe the first cDNA sequence encoding a juvenile hormone-specific epoxide hydrolase from an insect. A full-length cDNA clone revealed a 462-amino-acid open reading frame encoding an amino acid sequence with 44% identity and 64% similarity to human microsomal epoxide hydrolase. All residues in the catalytic triad (residues Asp227-His428-Asp350 in
Hubert Wojtasek, Glenn D. Prestwich
openaire +2 more sources
Epoxide Hydrolases and Their Synthetic Applications
1999Chiral epoxides and 1,2-diols, which are central building blocks for the asymmetric synthesis of bioactive compounds, can be obtained by using enzymes--i.e. epoxide hydrolases--which catalyse the enantioselective hydrolysis of epoxides. These biocatalysis have recently been found to be more widely distributed in fungi and bacteria than previously ...
R V, Orru +3 more
openaire +2 more sources
Rat Cytosolic Epoxide Hydrolase
1986Rat liver microsomal and cytosolic epoxide hydrolase may be distinguished through differences in substrate specificity: styrene 7,8-oxide is preferentially hydrolyzed by the microsomal form, while trans-stilbene oxide is the preferred substrate for cytosolic epoxide hydrolase. Large interindividual differences in the specific activity of Sprague-Dawley
F, Oesch +4 more
openaire +2 more sources
2018
Epoxide hydrolases (EHs) metabolize highly reactive epoxides with mutagenic and carcinogenic potential to the less reactive corresponding diols and are therefore traditionally viewed as detoxicating enzymes. In few instances, however, the diols themselves can be precursors of further reactive metabolites, and EH may thereby contribute to metabolic ...
Arand, Michael, Marowsky, Anne
openaire +1 more source
Epoxide hydrolases (EHs) metabolize highly reactive epoxides with mutagenic and carcinogenic potential to the less reactive corresponding diols and are therefore traditionally viewed as detoxicating enzymes. In few instances, however, the diols themselves can be precursors of further reactive metabolites, and EH may thereby contribute to metabolic ...
Arand, Michael, Marowsky, Anne
openaire +1 more source
Enantioselectivities of yeast epoxide hydrolases for 1,2-epoxides
Tetrahedron: Asymmetry, 1999Abstract Kinetic resolution of homologous series of unbranched 1,2-epoxyalkanes (C-4 to C-12), 1,2-epoxyalkenes (C-4, C-6 and C-8), a 2,2-dialkylsubstituted epoxide (2-methyl-1,2-epoxyheptane) and a benzyloxy-substituted epoxide (benzyl glycidyl ether) was investigated using resting cells of 10 different yeast strains.
Botes, A.L. +3 more
openaire +2 more sources
Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity
Biochemical and Biophysical Research Communications, 1990Purified leukotriene A4 hydrolase from human leukocytes is shown to exhibit peptidase activity towards the synthetic substrates alanine-4-nitroanilide and leucine-4-nitroanilide. The enzymatic activity is abolished after heat treatment (70 degrees C, 30 min).
J Z, Haeggström +3 more
openaire +2 more sources
Epoxide hydrolase and hepatocarcinogenesis
Trends in Pharmacological Sciences, 1981is commonly understood as a nonsynergistic or non-potentiating combination, whereas 'overadditive' is taken as synergism, also expressed as potentiation. The dose-additive method·'·" Table a) by differentiation of additive from overadditive effects allows conclusions about the mechanism of action of A and B.
openaire +1 more source