Results 41 to 50 of about 43,844 (154)
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]
, 2011 Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd +39 more
core +3 more sources
Properties of epoxide hydrolase from the yeast Rhodotorula glutinis [PDF]
, 2002 Epoxide hydrolases are ubiquitous enzymes that can be found in nearly all living organisms. Some of the enzymes play an important role in detoxifying xenobiotic and metabolic compounds.
Ariës-Kronenburg, N.A.E.
core
Enantiomeric Tartaric Acid Production Using cis-Epoxysuccinate Hydrolase: History and Perspectives
Molecules, 2019 Tartaric acid is an important chiral chemical building block with broad industrial and scientific applications. The enantioselective synthesis of l(+)- and d(−)-tartaric acids has been successfully achieved using bacteria presenting cis ...
Jinsong Xuan, Yingang Feng
doaj +1 more source
C‐Terminal Functionalization Methods of Amino Acids, Peptides, and Proteins
Chemistry – A European Journal, EarlyView.C‐terminal functionalization offers powerful routes to peptide and protein diversification, yet epimerization, hydrolysis, and selectivity remain key challenges. This Review surveys enzymatic, decarboxylative, and condensation strategies, highlighting advances toward chemo‐ and regioselective, protecting‐group‐free, atom‐efficient methods applicable to
Jay Hanssens +3 more
wiley +1 more source
The evolutionary relationship between epoxide hydrolases and dehalogenases [PDF]
, 2022 Enzymes are well-known for being remarkably selective catalysts. They are often able to catalyse reactions for certain molecules while leaving other similar molecules completely unchanged.
Schuiten, Eva Daniëlle
core +1 more source
Chemistry – A European Journal, EarlyView.A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley +1 more source
Enantioconvergent Hydrolysis of Styrene Epoxides by Newly Discovered Epoxide Hydrolases in Mung Bean
, 2016 Two novel epoxide hydrolases were discovered in mung bean (Phaseolus radiatus L.) for the first time, either of which can catalyze enantioconvergent hydrolysis of styrene epoxides.
Xin-Yan Wu (1490878) +4 more
core +3 more sources
Epilepsia Open, EarlyView.Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar +4 more
wiley +1 more source
Comparing the regio- and enantioselectivity of inverting versus retaining epoxide hydrolases [PDF]
, 2016 Epoxide hydrolases (EHs) are enzymes that catalyze the ring opening of an epoxide, yielding a vicinal diol. This exciting class of enzymes is often associated with natural product and small molecule biosynthesis. One interesting class of natural products
Aliwalas, Mark A
core
Journal of Applied Toxicology, EarlyView.ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley +1 more source