Results 41 to 50 of about 3,732 (161)

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto   +7 more
wiley   +1 more source

Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids[S]

open access: yesJournal of Lipid Research, 2019
A chiral lipidomics approach was established for comprehensive profiling of regio- and stereoisomeric monoepoxy and monohydroxy metabolites of long-chain PUFAs as generated enzymatically by cytochromes P450 (CYPs), lipoxygenases (LOXs), and ...
Maximilian Blum   +4 more
doaj   +1 more source

A first insight into Pycnoporus sanguineus BAFC 2126 transcriptome. [PDF]

open access: yesPLoS ONE, 2013
Fungi of the genus Pycnoporus are white-rot basidiomycetes widely studied because of their ability to synthesize high added-value compounds and enzymes of industrial interest.
Cristian O Rohr   +3 more
doaj   +1 more source

Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense

open access: yesNew Plant Protection, EarlyView.
Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley   +1 more source

The effect of deep eutectic solvents on the asymmetric hydrolysis of styrene oxide by mung bean epoxide hydrolases

open access: yesBioresources and Bioprocessing, 2018
Background Deep eutectic solvents have attracted considerable attention in numerous fields. There is little information on mung bean epoxide hydrolase-catalyzed epoxides in deep eutectic solvent-containing system.
Fei Peng   +4 more
doaj   +1 more source

Tolerance to dietary linalool primarily involves co-expression of cytochrome P450s and cuticular proteins in Pagiophloeus tsushimanus (Coleoptera: Curculionidae) larvae using SMRT sequencing and RNA-seq

open access: yesBMC Genomics, 2023
Background Pagiophloeus tsushimanus (Coleoptera: Curculionidae), an emerging forest pest exclusively infesting camphor trees, has recently caused severe ecological and economic damage in localized areas in China.
Shouyin Li, Hui Li, Cong Chen, Dejun Hao
doaj   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

open access: yesSmall, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem   +12 more
wiley   +1 more source

Exploring Solanum tuberosum Epoxide Hydrolase Internal Architecture by Water Molecules Tracking

open access: yesBiomolecules, 2018
Several different approaches are used to describe the role of protein compartments and residues in catalysis and to identify key residues suitable for the modification of the activity or selectivity of the desired enzyme.
Karolina Mitusińska   +4 more
doaj   +1 more source

Silencing of juvenile hormone‐related genes through RNA interference leads to molt failure and high mortality in the spongy moth

open access: yesInsect Science, EarlyView.
The feasibility of using RNA interference to control the globally important quarantine pest, the spongy moth. Targeting genes related to JHs play an important role in the growth and development of insects. First, the open reading frames (ORFs) of Ldjhamt and Ldjheh were identified and characterized, and the target genes were cloned and double‐stranded ...
Wenzhuai Ji   +3 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

open access: yesCell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen   +10 more
wiley   +1 more source

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