Results 41 to 50 of about 128,828 (279)

Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveMetabolites derived from N−3 and N−6 polyunsaturated fatty acids (PUFAs) have both beneficial and detrimental effects on the heart. However, contribution of these lipid mediators to dilated cardiomyopathy (DCM)-associated mitochondrial ...
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Gavin Y. Oudit, John M. Seubert, John M. Seubert, John M. Seubert   +15 more
doaj   +1 more source

Improving the 'tool box' for robust industrial enzymes. [PDF]

, 2017
This is the final version of the article. Available from Springer Verlag via the DOI in this record.The speed of sequencing of microbial genomes and metagenomes is providing an ever increasing resource for the identification of new robust biocatalysts ...
Littlechild, JA
core   +1 more source

Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity

Data in Brief, 2016
The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira, Patricia Pereira Adriani, Flavia Garcia Borges, Adriana Rios Lopes, Patricia T. Campana, Felipe S. Chambergo   +5 more
doaj   +1 more source

Epoxide hydrolases: biochemistry and molecular biology.

Chemico-Biological Interactions, 2000
A. Fretland, C. Omiecinski
semanticscholar   +3 more sources

The role of soluble epoxide hydrolase and its inhibitors in depression

Brain, Behavior, & Immunity - Health, 2021
Evidence suggests that around 30 ​% of patients with depression do not respond to antidepressant treatment, with most of them having sub-chronic levels of inflammation.
Alessandra Borsini
doaj   +1 more source

Detoxication Strategy of Epoxide Hydrolase—The Basis for a Novel Threshold for Definable Genotoxic Carcinogens

Dose-Response, 2004
From our recent work on the three-dimensional structure of epoxide hydrolases we theoretically deduced the likelihood of a two-step catalytic mechanism that we and others have subsequently experimentally confirmed.
Franz Oesch, Jan Georg Hengstler, Michael Arand   +2 more
doaj   +1 more source

Evidence for the role of EPHX2 gene variants in anorexia nervosa. [PDF]

, 2013
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants.
Bansal, V, Berenson, G, Bergen, AW, Berrettini, W, Bloss, CS, Brandt, H, Bulik, CM, Carson, A, Chen, W, Crawford, S, Crow, S, Darst, BF, Duvvuri, V, Fichter, MM, Galvez, L, Halmi, KA, Johnson, C, Kaplan, AS, Kaye, W, Keel, P, Klump, KL, La Via, M, Levy, S, Libiger, O, Lilenfeld, L, Magistretti, P, Mitchell, JE, Murray, S, Pham, P, Phillips, T, Plotnicov, K, Rotondo, A, Schork, NJ, Scott-Van Zeeland, AA, Shih, PB, Smith, EN, Srinivasan, S, Strober, M, Tewhey, R, Tisch, R, Topol, EJ, Torkamani, A, Treasure, J, Villarasa, N, Wineinger, N, Woodside, DB, Zhang, G   +46 more
core   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS ONE, 2017
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play an important role in blood pressure regulation, protection against ischemia-reperfusion injury, angiogenesis, and inflammation.
Samantha L Hoopes, Artiom Gruzdev, Matthew L Edin, Joan P Graves, J Alyce Bradbury, Gordon P Flake, Fred B Lih, Laura M DeGraff, Darryl C Zeldin   +8 more
doaj   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources