Epoxide Hydrolases: Multipotential Biocatalysts. [PDF]
Int J Mol Sci, 2023 Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs.
Bučko M +4 more
europepmc +6 more sources
Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during
mBio, 2016 Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman +2 more
doaj +3 more sources
New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Two novel epoxide hydrolases (EHs), Sibe-EH and CH65-EH, were identified in the metagenomes of samples collected in hot springs in Russia and China, respectively.
Erica Elisa Ferrandi +8 more
doaj +3 more sources
Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function [PDF]
Journal of Lipid Research, 2018 Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi +6 more
doaj +3 more sources
Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. [PDF]
Int J Mol Sci, 2021 Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of biological activities, including the regulation of blood pressure, inflammation, angiogenesis, and pain perception.
Morisseau C +5 more
europepmc +2 more sources
The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease. [PDF]
Int J Mol Sci, 2020 Epoxide hydrolases (EHs) are key enzymes involved in the detoxification of xenobiotics and biotransformation of endogenous epoxides. They catalyze the hydrolysis of highly reactive epoxides to less reactive diols.
Gautheron J, Jéru I.
europepmc +2 more sources
Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia [PDF]
Current Research in Structural Biology, 2021 Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate epoxide ring in
Noor M. Taher +8 more
doaj +2 more sources
Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network [PDF]
Computational and Structural Biotechnology Journal, 2022 Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the ...
Karolina Mitusińska +7 more
doaj +2 more sources
Role of epoxide hydrolases in lipid metabolism. [PDF]
Biochimie, 2013 Morisseau C.
europepmc +4 more sources
Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 (R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke.
Dong Zhang +5 more
doaj +2 more sources