Results 11 to 20 of about 3,732 (161)

Time‐of‐Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins [PDF]

Exploration
Modulation of circadian rhythms impairs homeostasis, resulting in altered susceptibility to disease development. New perspectives on nutrition emphasize the circadian timing of food intake.
Yanjun Liu, Meishan Lu, Yanpeng Du, Jie Xu, Mingjie Fan, Changhu Xue, Yuanfa Liu   +6 more
doaj   +2 more sources

Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1 [PDF]

Applied and Environmental Microbiology
Isobutylene (IB) is produced on a large scale by the petrochemical industry and is metabolized by the aerobic alkene-metabolizing bacterium Mycolicibacterium sp. ELW1. The initial metabolite of IB catabolism by this bacterium is proposed to be 2-methyl-1,
Nicholas W. Faulkner, John B. Joyce, Christy Smith, Paul Swartz, Robert B. Rose, Eric S. Miller, Michael R. Hyman   +6 more
doaj   +2 more sources

Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function [PDF]

Journal of Lipid Research, 2018
Lipoxygenase (LOX)-catalyzed oxidation of the essential fatty acid, linoleate, represents a vital step in construction of the mammalian epidermal permeability barrier.
Haruto Yamanashi, William E. Boeglin, Christophe Morisseau, Robert W. Davis, Gary A. Sulikowski, Bruce D. Hammock, Alan R. Brash   +6 more
doaj   +2 more sources

Epoxide Hydrolase Family: Biological Functions, Disease Mechanisms, and Emerging Therapeutic Strategies [PDF]

Biology
Epoxide hydrolases (EHs) constitute a conserved enzyme family that catalyzes the hydrolysis of epoxides into less reactive diols. Beyond their canonical roles in xenobiotic detoxification, EHs have emerged as critical regulators of lipid metabolism ...
Yadan Tan, Jingjing Xu, Ziteng Huang, Xiran Wang, Jinshan Xing, Shengbiao Li, Jingyan Yi   +6 more
doaj   +2 more sources

Reply to “Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases” [PDF]

mBio, 2017
Daniel E. Goldberg, Natalie J. Spillman
doaj   +2 more sources

Corrigendum to “Structure–function relationship between soluble epoxide hydrolases structure and their tunnel network” [Comput. Struct. Biotechnol. J. 20 (2022) 193–205] [PDF]

Computational and Structural Biotechnology Journal, 2022
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra   +7 more
doaj   +2 more sources

Role of epoxide hydrolases in lipid metabolism [PDF]

Biochimie, 2013
Christophe Morisseau
exaly   +2 more sources

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

eLife, 2021
Epoxide hydrolases (EHs) regulate cellular homeostasis through hydrolysis of epoxides to less-reactive diols. The first discovered EH was EPHX1, also known as mEH.
Jeremie Gautheron, Christophe Morisseau, Wendy K Chung, Jamila Zammouri, Martine Auclair, Genevieve Baujat, Emilie Capel, Celia Moulin, Yuxin Wang, Jun Yang, Bruce D Hammock, Barbara Cerame, Franck Phan, Bruno Fève, Corinne Vigouroux, Fabrizio Andreelli, Isabelle Jeru   +16 more
doaj   +1 more source

Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
openaire   +4 more sources

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source