Epoxide Hydrolases: Multipotential Biocatalysts [PDF]
International Journal of Molecular Sciences, 2023 Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs. In this review article, we discuss the state of the art and development potential of epoxide hydrolases as biocatalysts based on ...
Marek Bucko +2 more
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Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases. [PDF]
mBio, 2017 Arand M, Marowsky A.
europepmc +7 more sources
The prognostic significance of epoxide hydrolases in colorectal cancer [PDF]
Biochemistry and Biophysics ReportsColorectal cancer (CRC) is a common malignant cancer. Epoxide hydrolases (EHs) are involved in the development of cancer by regulating epoxides, but their relationship with CRC is unclear.
Lichao Cao, Ying Ba, ShenRui Zhang
exaly +4 more sources
Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia. [PDF]
Curr Res Struct Biol, 2021 Epoxide hydrolases catalyze the conversion of epoxides to vicinal diols in a range of cellular processes such as signaling, detoxification, and virulence. These enzymes typically utilize a pair of tyrosine residues to orient the substrate epoxide ring in
Taher NM +8 more
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Structure-function relationship between soluble epoxide hydrolases structure and their tunnel network. [PDF]
Comput Struct Biotechnol J, 2022 Enzymes with buried active sites maintain their catalytic function via a single tunnel or tunnel network. In this study we analyzed the functionality of soluble epoxide hydrolases (sEHs) tunnel network, by comparing the overall enzyme structure with the ...
Mitusińska K +7 more
europepmc +2 more sources
Gram-Scale Synthesis of (R)-P-Chlorophenyl-1,2-Ethanediol at High Concentration by a Pair of Epoxide Hydrolases. [PDF]
Front Bioeng Biotechnol, 2022 (R)-p-chlorophenyl-1,2-ethanediol (pCPED) is an important intermediate for the synthesis of (R)-eliprodil that is widely applied in the treatment of ischemic stroke.
Zhang D +5 more
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Cloning and Characterization of Drosophila melanogaster Juvenile Hormone Epoxide Hydrolases (JHEH) and Their Promoters. [PDF]
Biomolecules, 2022 Juvenile hormone epoxide hydrolase (JHEH) plays an important role in the metabolism of JH III in insects. To study the control of JHEH in female Drosophila melanogaster, JHEH 1, 2 and 3 cDNAs were cloned and sequenced.
Borovsky D +6 more
europepmc +2 more sources
Evolution of tunnels in α/β-hydrolase fold proteins-What can we learn from studying epoxide hydrolases? [PDF]
PLoS Comput Biol, 2022 The evolutionary variability of a protein's residues is highly dependent on protein region and function. Solvent-exposed residues, excluding those at interaction interfaces, are more variable than buried residues whereas active site residues are ...
Bzówka M +7 more
europepmc +2 more sources
Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection. [PDF]
mBio, 2016 Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Spillman NJ, Dalmia VK, Goldberg DE.
europepmc +2 more sources
Reply to "Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases". [PDF]
mBio, 2017 Goldberg DE, Spillman NJ.
europepmc +2 more sources