Results 11 to 20 of about 43,844 (154)

Epoxide Hydrolases: Multipotential Biocatalysts [PDF]

International Journal of Molecular Sciences, 2023
Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs.
Helena Hronská, Marek Bucko, Peter Gemeiner   +2 more
exaly   +3 more sources

Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1 [PDF]

Applied and Environmental Microbiology
Isobutylene (IB) is produced on a large scale by the petrochemical industry and is metabolized by the aerobic alkene-metabolizing bacterium Mycolicibacterium sp. ELW1. The initial metabolite of IB catabolism by this bacterium is proposed to be 2-methyl-1,
Nicholas W. Faulkner, John B. Joyce, Christy Smith, Paul Swartz, Robert B. Rose, Eric S. Miller, Michael R. Hyman   +6 more
doaj   +2 more sources

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides [PDF]

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +2 more sources

Epoxide Hydrolase Family: Biological Functions, Disease Mechanisms, and Emerging Therapeutic Strategies [PDF]

Biology
Epoxide hydrolases (EHs) constitute a conserved enzyme family that catalyzes the hydrolysis of epoxides into less reactive diols. Beyond their canonical roles in xenobiotic detoxification, EHs have emerged as critical regulators of lipid metabolism ...
Yadan Tan, Jingjing Xu, Ziteng Huang, Xiran Wang, Jinshan Xing, Shengbiao Li, Jingyan Yi   +6 more
doaj   +2 more sources

Gut microbiome-derived hydrolases—an underrated target of natural product metabolism [PDF]

Frontiers in Cellular and Infection Microbiology
In recent years, there has been increasing interest in studying gut microbiome-derived hydrolases in relation to oral drug metabolism, particularly focusing on natural product drugs.
Jiaxin He, Xiaofeng Liu, Junming Zhang, Rong Wang, Xinyuan Cao, Xinyuan Cao, Ge Liu   +6 more
doaj   +2 more sources

Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases [PDF]

mBio, 2017
Michael Arand, Anne Marowsky
doaj   +2 more sources

Reply to “Misclassification of PfEH1 and PfEH2 as Epoxide Hydrolases” [PDF]

mBio, 2017
Daniel E. Goldberg, Natalie J. Spillman
doaj   +2 more sources

Corrigendum to “Structure–function relationship between soluble epoxide hydrolases structure and their tunnel network” [Comput. Struct. Biotechnol. J. 20 (2022) 193–205] [PDF]

Computational and Structural Biotechnology Journal, 2022
Karolina Mitusińska, Piotr Wojsa, Maria Bzówka, Agata Raczyńska, Weronika Bagrowska, Aleksandra Samol, Patryk Kapica, Artur Góra   +7 more
doaj   +2 more sources

EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence

eLife, 2021
Epoxide hydrolases (EHs) regulate cellular homeostasis through hydrolysis of epoxides to less-reactive diols. The first discovered EH was EPHX1, also known as mEH.
Jeremie Gautheron, Christophe Morisseau, Wendy K Chung, Jamila Zammouri, Martine Auclair, Genevieve Baujat, Emilie Capel, Celia Moulin, Yuxin Wang, Jun Yang, Bruce D Hammock, Barbara Cerame, Franck Phan, Bruno Fève, Corinne Vigouroux, Fabrizio Andreelli, Isabelle Jeru   +16 more
doaj   +1 more source

Identification and catalytic properties of new epoxide hydrolases from the genomic data of soil bacteria. [PDF]

Enzyme Microb Technol, 2020
Epoxide hydrolases (EHs) catalyse the conversion of epoxides into vicinal diols. These enzymes have extensive value in biocatalysis as they can generate enantiopure epoxides and diols which are important and versatile synthetic intermediates for the fine
Stojanovski G, Dobrijevic D, Hailes HC, Ward JM.   +3 more
europepmc   +3 more sources