Results 71 to 80 of about 115,061 (305)

Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones [PDF]

, 2018
An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin.
Allen, Ashley, Bao, Berkessel, Birchall, Bringmann, Bringmann, Chen, Corey, Crimmins, Dao, Donner, Dwyer, Flegel, Frandsen, Gao, Gray, Helder, Jew, Konkol, Lee, Leeper, Liau, Masson, Morishita, Natori, Romaine, Shi, Shibata, Shibata, Shibata, Shirakawa, Shirakawa, Sperry, Sun, Takeya, Takizawa, Varun, Wu, Yeung, Zeeck, Zhang, Ōki   +42 more
core   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Merging Biocatalysis and Chemocatalysis in Flow: State‐of‐the‐Art and Future Directions for Sustainable Synthesis

Angewandte Chemie, EarlyView.
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis, Matteo Damian, Francesco G. Mutti   +2 more
wiley   +2 more sources

Primary Structure and Catalytic Mechanism of the Epoxide Hydrolase from Agrobacterium radiobacter AD1 [PDF]

, 1997
The epoxide hydrolase gene from Agrobacterium radiobacter AD1, a bacterium that is able to grow on epichlorohydrin as the sole carbon source, was cloned by means of the polymerase chain reaction with two degenerate primers based on the N-terminal and C ...
Altschul, Andrade, Arand, Arand, Armstrong, Ausubel, Beetham, Beetham, Bell, Burley, Dick B. Janssen, Dı́az, Falany, Fujio, Geourjon, Grant, Hassett, Hecht, Heidelbach, Innis, Itzhaki, Jacobs, Janssen, Janssen, Johnson, Kawasaki, Kiyosue, Knehr, Kunkel, Lacourciere, Loewenthal, Marko Fennema, Mehta, Miller, Minke Smids, Noble, Ollis, Pries, Provencher, Rick Rink, Rost, Sambrook, Sanger, Schanstra, Skoda, Solovyev, Sreerama, Stapleton, Studier, Thomas, Thompson, Uwe Dehmel, Van den Wijngaard, Verschueren, Verschueren, Wang, Wilson, Winkler, Wojtasek, Yanisch-Perron   +59 more
core   +3 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Chemo-Enzymatic Synthesis of Chiral Epoxides Ethyl and Methyl (S)-3-(Oxiran-2-yl)propanoates from Renewable Levoglucosenone: An Access to Enantiopure (S)-Dairy Lactone

Molecules, 2016
Chiral epoxides—such as ethyl and methyl (S)-3-(oxiran-2-yl)propanoates ((S)-1a/1b)—are valuable precursors in many chemical syntheses. Until recently, these compounds were synthesized from glutamic acid in four steps (deamination, reduction, tosylation ...
Aurélien A. M. Peru, Amandine L. Flourat, Christian Gunawan, Warwick Raverty, Martyn Jevric, Ben W. Greatrex, Florent Allais   +6 more
doaj   +1 more source

Unexpected Formation of Oxetanes during the Synthesis of Dodeco-6,7-diuloses

Molbank, 2020
During the synthesis of symmetrical dodeco-6,7-diuloses that are potential candidates for inhibition of glycosidases, an unanticipated epoxide-oxetane rearrangement was observed.
Marius Bayer, Cäcilia Maichle-Mössmer, Thomas Ziegler   +2 more
doaj   +1 more source

Stabilization of Single Metal Atoms on Graphitic Carbon Nitride: Synthetic Strategies and Emerging Applications

Advanced Science, EarlyView.
This review highlights recent advancements in stabilizing single metal atoms on graphitic carbon nitride emphasizing innovative synthesis strategies and emerging applications in electrocatalysis, photocatalysis and organic transformations, along with key challenges and future perspective. Abstract Emerging as a new frontier in catalysis science, single‐
Wenyao Zhang, Junjie Cui, Zhenjie Yao, Boyuan Zhu, Nithinraj Panangattu Dharmarajan, Ajayan Vinu, Junwu Zhu   +6 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Synthesis of an Epoxide for TMM Cycloadditions [PDF]

, 2013
In order to produce a highly functionalized five-membered ring useful for further synthetic processes via Palladium catalysis, a series of precursors need to be synthesized in order to form the epoxide used in cyclic formation.
Freeland, Chase, Prusinski, Will
core   +2 more sources