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Epoxide Hydrolase in Human Fetal Liver
Pharmacology, 1983Epoxide hydrolase activity towards styrene oxide was measured in the microsomal fraction of 20 human fetal livers. The enzymatic activity was 5.60 +/- 0.52 nmol/min/mg (mean +/- SE) which is about 40% of the previously reported value in human adult liver microsomes. No relation between enzymatic activity and fetal age was observed.
G M, Pacifici, A, Rane
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Epoxide hydrolase and hepatocarcinogenesis
Trends in Pharmacological Sciences, 1981is commonly understood as a nonsynergistic or non-potentiating combination, whereas 'overadditive' is taken as synergism, also expressed as potentiation. The dose-additive method·'·" Table a) by differentiation of additive from overadditive effects allows conclusions about the mechanism of action of A and B.
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[46] Microsomal epoxide hydrolase
1981Publisher Summary Microsomal epoxide hydrolase catalyzes the conversionof epoxides to glycols. The microsomal enzyme should not be confused with another epoxide hydrolase activity, found primarily in the cytosolic fraction, which differs greatly from membrane-bound enzyme in substrate specificity and immunological properties.
Thomas M. Guenthner +2 more
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