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Whole Body Mouse EPR Oxygen Imaging of Implanted Beta Cell Replacement Devices
ISMRM Annual MeetingBeta-cell replacement therapy remains the only approach with a clinical proof-of-concept that demonstrates long-term insulin independence can be achieved in type 1 diabetic (T1D) patients. The major challenge for beta cell replacement devices is to keep cells viable by avoiding hypoxia until vascularization is established.
Mrignayani Kotecha +7 more
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2003
Nitric oxide (NO·) is widely accepted as a key component in the maintenance of resting cerebral blood flow (CBF). The complex interaction between NO· and other regulatory mediators such as neural activity, pH and arterial pCO2 determines the tone of cerebral blood vessels and thus oxygen delivery through blood flow 1−3.
Matthew P, Thomas +2 more
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Nitric oxide (NO·) is widely accepted as a key component in the maintenance of resting cerebral blood flow (CBF). The complex interaction between NO· and other regulatory mediators such as neural activity, pH and arterial pCO2 determines the tone of cerebral blood vessels and thus oxygen delivery through blood flow 1−3.
Matthew P, Thomas +2 more
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Biochemistry, 2002
Ribonucleotide reductase (RNR) catalyzes the biosynthesis of deoxyribonucleotides. The active enzyme contains a diiron center and a tyrosyl free radical required for enzyme activity. The radical is located at Y177 in the R2 protein of mouse RNR. The radical is formed concomitantly with the mu-oxo-bridged diferric center in a reconstitution reaction ...
Adrait, A. +4 more
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Ribonucleotide reductase (RNR) catalyzes the biosynthesis of deoxyribonucleotides. The active enzyme contains a diiron center and a tyrosyl free radical required for enzyme activity. The radical is located at Y177 in the R2 protein of mouse RNR. The radical is formed concomitantly with the mu-oxo-bridged diferric center in a reconstitution reaction ...
Adrait, A. +4 more
openaire +3 more sources
Physiology
Background: Inflammatory bowel disease (IBD) refers to a group of chronic, complex, relapsing and remitting inflammatory disorders that affect the gastrointestinal (GI) tract. Crohn’s disease (CD) and ulcerative colitis (UC) are the two commonly diagnosed forms of IBD that affect over 3 million Americans, or 1.3% of the US population.
Murugesan Velayutham +3 more
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Background: Inflammatory bowel disease (IBD) refers to a group of chronic, complex, relapsing and remitting inflammatory disorders that affect the gastrointestinal (GI) tract. Crohn’s disease (CD) and ulcerative colitis (UC) are the two commonly diagnosed forms of IBD that affect over 3 million Americans, or 1.3% of the US population.
Murugesan Velayutham +3 more
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Physiology
Introduction and rationale: The Exercise pressor reflex (EPR) is a physiological mechanism in which the contraction of skeletal muscle results in a rise in heart rate (HR) and mean arterial pressure (MAP). In patients with Peripheral Artery Disease (PAD), this reflex is exaggerated, leading to abnormally high elevations in blood pressure during ...
Eunice Oribamise +5 more
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Introduction and rationale: The Exercise pressor reflex (EPR) is a physiological mechanism in which the contraction of skeletal muscle results in a rise in heart rate (HR) and mean arterial pressure (MAP). In patients with Peripheral Artery Disease (PAD), this reflex is exaggerated, leading to abnormally high elevations in blood pressure during ...
Eunice Oribamise +5 more
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JBIC Journal of Biological Inorganic Chemistry, 2006
The 1H NMR chemical shifts of the heme methyl groups of the ferriheme complex of metneuroglobin (Du et al. in J. Am. Chem. Soc. 125:8080-8081, 2003) predict orientations of the axial histidine ligands (Shokhirev and Walker in J. Biol. Inorg. Chem. 3:581-594, 1998) that are not consistent with the X-ray data (Vallone et al. in Proteins Struct.
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The 1H NMR chemical shifts of the heme methyl groups of the ferriheme complex of metneuroglobin (Du et al. in J. Am. Chem. Soc. 125:8080-8081, 2003) predict orientations of the axial histidine ligands (Shokhirev and Walker in J. Biol. Inorg. Chem. 3:581-594, 1998) that are not consistent with the X-ray data (Vallone et al. in Proteins Struct.
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The Effect of Aging for Oxidative Stress in Mouse Brains by EPR Imaging Method
Free Radical Biology and Medicine, 2014Miho C Emoto +4 more
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MEASUREMENT OF PO2 IN MOUSE OOCYTES USING EPR OXIMETRY
The Journal of Reproduction and Development Supplement, 2008HIGAKI, SHOGO +3 more
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Ascorbyl EPR Doublet Signal in Normal Mouse Liver Oxygenated Homogenates
Spectroscopy Letters, 1968openaire +1 more source