Results 61 to 70 of about 947,323 (274)

Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity

Biomolecules, 2021
A series of thiosemicarbazone-coumarin hybrids (HL1-HL3 and H2L4) has been synthesised in 12 steps and used for the preparation of mono- and dinuclear copper(II) complexes, namely Cu(HL1)Cl2 (1), Cu(HL2)Cl2 (2), Cu(HL3)Cl2 (3) and Cu2(H2L4)Cl4 (4 ...
Iryna Stepanenko, Maria V. Babak, Gabriella Spengler, Marta Hammerstad, Ana Popovic-Bijelic, Sergiu Shova, Gabriel E. Büchel, Denisa Darvasiova, Peter Rapta, Vladimir B. Arion   +9 more
doaj   +1 more source

Non-invasive measurement of melanin-derived radicals in living mouse tail using X-band EPR

Journal of Clinical Biochemistry and Nutrition, 2016
The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer.
Ogawa, Yukihiro, Ueno, Megumi, Sekine-Suzuki, Emiko, Nakanishi, Ikuo, Matsumoto, Ken-ichiro, Fujisaki, Shingo   +5 more
openaire   +3 more sources

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Analysis of influenza A virus NS1 dimer interfaces in solution by pulse EPR distance measurements [PDF]

, 2014
H.L.T. was supported by the University of St Andrews; S.A.J. is supported by the BBSRC, U.K.; P.S.K. is supported by the Medical Research Council, U.K.; B.E.B.
Kerry, Philip S, Bode, Bela Ernest, Jameison, Stephen A, Stephen A. Jameison, Ackermann, Katrin, Katrin Ackermann, Turkington, Hannah L, Philip S. Kerry, Bela E. Bode, Hannah L. Turkington, Ackermann, Katrin; id_orcid, Bode, Bela Ernest; id_orcid   +11 more
core   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Validez de criterio del test sit-and-reach como medida de la extensibilidad isquiosural en piragüistas

Cultura, Ciencia y Deporte, 2012
Los objetivos del estudio fueron determinar la validez de criterio concurrente del test sit-and-reach como medida de la extensibilidad isquiosural en piragüistas, en función de la disciplina practicada (kayak o canoa), así como la validez de la ...
P.A. López-Miñarro, R. Vaquero-Cristóbal, J.M. Muyor, F. Alacid, M. Isorna   +4 more
doaj  

An evolutionary approach to modelling concrete degradation due to sulphuric acid attack [PDF]

, 2014
Concrete corrosion due to sulphuric acid attack is known to be one of the main contributory factors for degradation of concrete sewer pipes. This paper proposes to use a novel data mining technique, namely, evolutionary polynomial regression (EPR), to ...
Alani, Amir M., Faramarzi, Asaad, Asaad Faramarzi, Alani, Amir, Faramarzi, Asaad; id_orcid, Amir M. Alani   +5 more
core   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity.

PLoS ONE, 2013
In order to elucidate factors that determine substrate specificity and activity of mammalian molybdo-flavoproteins we performed site directed mutagenesis of mouse aldehyde oxidase 3 (mAOX3).
Martin Mahro, Natércia F Brás, Nuno M F S A Cerqueira, Christian Teutloff, Catarina Coelho, Maria João Romão, Silke Leimkühler   +6 more
doaj   +1 more source

Use of 3‐acetoxymethoxycarbonyl‐2,2,5,5‐tetramethyl‐1‐pyrrolidinyloxyl as an EPR oximetry probe: Potential for in vivo measurement of tissue oxygenation in mouse brain [PDF]

Magnetic Resonance in Medicine, 2006
AbstractMeasurement of oxygen concentration and distribution in the brain is essential for understanding the pathophysiology of stroke. Low‐frequency electron paramagnetic resonance (EPR) spectroscopy with a paramagnetic probe is an attractive imaging modality that potentially can be used to map O2 concentration in the brain. We examined two nitroxides,
Shen, J, Liu, S, Miyake, M, Liu, W, Pritchard, A, Kao, JPY, Rosen, GM, Tong, Y, Liu, KJ   +8 more
openaire   +4 more sources