Results 51 to 60 of about 947,323 (274)

Combination Therapy with Doxorubicin-Loaded Reduced Albumin Nanoparticles and Focused Ultrasound in Mouse Breast Cancer Xenografts

Pharmaceuticals, 2020
Because chemotherapeutic drugs are often associated with serious side effects, the central topic in modern drug delivery is maximizing the localization of drugs at the target while minimizing non-specific drug interactions at unwanted regions. To address
Daehyun Kim, Seung Soo Lee, Woo Young Yoo, Hyungwon Moon, Aesin Cho, So Yeon Park, Yoon-Seok Kim, Hyun Ryoung Kim, Hak Jong Lee   +8 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Glutathione Detection Method Based on Electron Paramagnetic Resonance Spectroscopy

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveGlutathione (γ-glutamyl-L-cysteinylglycine, GSH) is the most abundant non-protein compound containing sulfhydryl (―SH) groups in cells. It serves as a source of reducing equivalents, effectively neutralizing harmful reactive substances, and ...
WANG Zhi-Wen, KUANG Jian, LIU Ao-Kun, WEI Ruo-Tong, YU Lu, TIAN Chang-Lin   +5 more
doaj   +1 more source

Nitrosyl-hemoglobin formation in rodent and human venous erythrocytes reflects NO formation from the vasculature in vivo.

PLoS ONE, 2018
Reduced bioavailability of nitric oxide (NO) is a major feature of endothelial dysfunction characteristic of cardiovascular and metabolic diseases but the short half-life of NO precludes its easy quantification in circulating blood for early diagnosis ...
Flavia Dei Zotti, Irina I Lobysheva, Jean-Luc Balligand   +2 more
doaj   +1 more source

The ALFA (Activity Log Files Aggregation) Toolkit: A Method for Precise Observation of the Consultation

Journal of Medical Internet Research, 2008
BackgroundThere is a lack of tools to evaluate and compare Electronic patient record (EPR) systems to inform a rational choice or development agenda. ObjectiveTo develop a tool kit to measure the impact of different EPR system features on the
de Lusignan, Simon, Kumarapeli, Pushpa, Chan, Tom, Pflug, Bernhard, van Vlymen, Jeremy, Jones, Beryl, Freeman, George K   +6 more
doaj   +1 more source

Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway

Redox Biology, 2021
Oxidation of engineered nanomaterials during application in various industrial sectors can alter their toxicity. Oxidized nanomaterials also have widespread industrial and biomedical applications.
Nairrita Majumder, Murugesan Velayutham, Dimitrios Bitounis, Vamsi K. Kodali, Md Habibul Hasan Mazumder, Jessica Amedro, Valery V. Khramtsov, Aaron Erdely, Timothy Nurkiewicz, Philip Demokritou, Eric E. Kelley, Salik Hussain   +11 more
doaj   +1 more source

Location of anthralin radical generation in mouse skin by UV‐A irradiation: An estimation using microscopic EPR spectral‐spatial imaging [PDF]

Magnetic Resonance in Medicine, 2006
AbstractIn vivo location of the anthralin radical generated in mouse skin by ultraviolet A (UV‐A) irradiation was estimated by microscopic electron paramagnetic resonance (EPR) spectral‐spatial imaging. An X‐band EPR spectrometer equipped with specially designed high‐power imaging coils and a TE‐mode cavity was employed. The maximum field gradient used
Ken-ichiro, Matsumoto, Sayo, Kawai, Colin F, Chignell, Hideo, Utsumi   +3 more
openaire   +2 more sources

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Redox-Sensitive Mapping of a Mouse Tumor Model Using Sparse Projection Sampling of Electron Paramagnetic Resonance

, 2021
Aims: This work aimed to establish an accelerated imaging system for redox-sensitive mapping in a mouse tumor model using electron paramagnetic resonance (EPR) and nitroxyl radicals.
Matsumoto, Shingo, Yasui, Hironobu, Nakano, Hitomi, Inanami, Osamu, Kimura, Kota, Iguchi, Nami, Hirata, Hiroshi, Nami Iguchi, Hironobu Yasui, Hitomi Nakano, Osamu Inanami, Hiroshi Hirata, Kota Kimura, Shingo Matsumoto   +13 more
core   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source