Results 191 to 200 of about 1,430,726 (305)

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Histidine-Copper Site Variability in UiO-66: Monitoring Synthetic Intricacy with EPR Spectroscopy. [PDF]

Chem Mater
Aunan E, Gerz I, Lillerud KP, DeBeer S, Olsbye U.   +4 more
europepmc   +1 more source

Mechanism of Direct Acoustic Construction and Gradient Properties Tuning

Advanced Science, EarlyView.
Directed acoustic construction enables omnidirectional gradient tuning of fingerprint‐inspired microstructures. By investigating the DAC mechanisms, diamond particles are found to enhance acoustic physical, mechanical, and chemical effects, promoting acoustic curing and broadening the range of gradient property tuning.
Dandan Wu, Lijuan Zheng, Guang Yao, Zijun Liu, Liyan Luo, Cile Liang, Chengyong Wang   +6 more
wiley   +1 more source

Recent advances in quantifying protein conformational ensembles with dipolar EPR spectroscopy. [PDF]

Curr Opin Struct Biol
Dastvan R, Stoll S.
europepmc   +1 more source

HDX-guided EPR spectroscopy to interrogate membrane protein dynamics. [PDF]

STAR Protoc, 2022
Lane BJ, Wang B, Ma Y, Calabrese AN, El Mkami H, Pliotas C.   +5 more
europepmc   +1 more source

Thermally Regulated Methanol Selectivity in Photo‐Thermo Methane Oxidation Through Interfacial Methyl Transfer

Advanced Science, EarlyView.
Photo‐thermo cascade catalysis enables highly selective methane‐to‐methanol conversion over Au‐ZnO, achieving a CH3OH production rate of ∼800 µmol h−1 with 86% selectivity. Thermal activation gates the transfer of methane‐derived methyl intermediates from ZnO to Au, thereby redirecting the reaction pathway toward methanol formation. ABSTRACT The direct
Youxun Xu, Chengzhi Guo, Chaoran Jiang, Leirun Chen, Juncong Wang, Enqi Chen, Yang Lan   +6 more
wiley   +1 more source

Probing the connection between chirality and spin through time-resolved EPR spectroscopy. [PDF]

Proc Natl Acad Sci U S A
Saxena S, Waldeck DH.
europepmc   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen <i>Borrelia burgdorferi</i>. [PDF]

mBio
Londoño AF, Sharma A, Kathiresan V, Sealy J, Volpe RP, Gostinčar C, Pal U, Dumler JS, Hoffman BM, Daly MJ.   +9 more
europepmc   +1 more source