Results 101 to 110 of about 46,319 (267)

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

CFD Analysis of Dual‐Layer PCM Roofs for Thermal Mitigation in Residential Buildings

Heat Transfer, EarlyView.
ABSTRACT This study presents a computational fluid dynamics analysis of dual‐layer phase change material (PCM) roofs for passive cooling in residential buildings under the hot and humid climate of Bangladesh. A three‐dimensional transient model was developed in ANSYS Fluent using the enthalpy–porosity approach to simulate coupled heat conduction ...
Mohammad Junaid, Sakhawat Hossan Robel, Mahmud Or‐Rashid, Pabel Shahrear, Md Shajedul Karim, Suvash C. Saha, Goutam Saha   +6 more
wiley   +1 more source

Diseño térmico del instrumento EPE (Energetic Particles Experiment) = EPE (Energetic Particles Experiment) termal control analysis

, 2017
Diseño térmico del instrumento EPE (Energetic Particles Experiment)
openaire   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, EarlyView.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Suppressing vertical aluminum growth via accelerated interfacial Cl− dynamics for high‐areal‐capacity, long‐life aluminum metal anodes

InfoMat, EarlyView.
Through systematic analysis, we identified that cell failure of aluminum metal anodes via electrode short circuits arises from inefficient Cl− removal, which promotes vertical Al growth through localized reaction product accumulation. To address this, we developed a 3D nanostructured graphitic carbon electrode (3D‐GCE) and a Cl‐doped polypropylene (Cl ...
Yeong Hoon Heo, Juhee Yoon, Minhyuck Park, Do Hyun Kim, Jong Chan Hyun, Sion Kim, Jimin Park, Jisoo Kim, Son Ha, Jiyun Yeon, Jeonghun Lee, Hyoung‐Joon Jin, Hyung‐Kyu Lim, Young Soo Yun   +13 more
wiley   +1 more source

Achieving superior therapeutic effects on methicillin‐resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer

Interdisciplinary Medicine, EarlyView.
The sulfonated zwitterionic photosensitizer (PYSO3) is synthesized by reacting maleic anhydride derivatives with 4‐aminopyridine to form PY, followed by sulfonation with 1,4‐butane sultone. It exhibits both photothermal and photodynamic properties, enabling effective eradication of MRSA and biofilms, as well as promoting wound healing in mice ...
Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun   +10 more
wiley   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source

Monocytes with trained immunity–like signatures are associated with acute anterior uveitis in ankylosing spondylitis

Interdisciplinary Medicine, EarlyView.
In ankylosing spondylitis‐acute anterior uveitis (AS‐AAU), trained immunity monocytes (Mono‐TI) differentiate into macrophages in the eye, retaining trained immunity features. Mono‐TI cells secrete pro‐inflammatory cytokines and chemokines, including IL‐1β, TNF‐α, and CCL3.
Yimeng Sun, Lu Zhang, Xinyu Yao, Yunfei Liu, Xin Li, Feng Wen, Yong Dai, Ye Dai, Ziyu Du, Dijie Qiao, Ziwei Meng, Cong Hu, Chun Yan, Wei Chi   +13 more
wiley   +1 more source

Beyond the Metrics: Context‐Aware Calibration for Better Drain Flow Modelling

Irrigation and Drainage, EarlyView.
ABSTRACT Robust hydrological and water quality modelling is essential for advancing the understanding and management of engineered agricultural subsurface drainage systems. Achieving credible model output hinges on calibration strategies that are both rigorous and context sensitive. At the field scale, accurately capturing the dynamics of nutrient load
R. Caleb Bruhn, Anamelechi Falasy, Richard A. C. Cooke, Rabin Bhattarai   +3 more
wiley   +1 more source