Results 131 to 140 of about 1,035,128 (230)

Control of ultrafast hot electron dynamics in epsilon-near-zero conductive oxide thin films. [PDF]

open access: yesSci Adv
Gurung S   +8 more
europepmc   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

open access: yesAdvanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee   +4 more
wiley   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

open access: yesAdvanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen   +7 more
wiley   +1 more source

Iron Carbides in Fischer–Tropsch Synthesis: Theoretical and Experimental Understanding in Epsilon-Iron Carbide Phase Assignment

open access: yes, 2017
Xingchen Liu   +10 more
semanticscholar   +1 more source

A Machine Learning‐Driven Pore‐Scale Network Model Coupling Reaction Kinetics and Interparticle Transport for Catalytic Process Design

open access: yesAdvanced Science, EarlyView.
Designing catalytic processes in porous reactors requires resolving coupled multiscale reaction–transport phenomena. We develop a machine‐learning‐accelerated pore‐scale dual‐network model with kinetics (DNMK), which captures reaction kinetics, pore‐scale transport, and reactor‐level behavior.
Ming‐Liang Qu   +10 more
wiley   +1 more source

Programmable synthesis of alkaloidal frameworks integrating Michael acceptor generates covalent probes for targeting POLE3 in HBV replication. [PDF]

open access: yesRSC Chem Biol
Kaneko N   +13 more
europepmc   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo   +12 more
wiley   +1 more source

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