Results 161 to 170 of about 16,454 (219)
Factors that control amplitude of EPSPs in dendritic neurons [PDF]
Journal of Neurophysiology, 1983 We have used a computer-based mathematical model of alpha-motoneurons and of group Ia synaptic input to them, based on anatomical and electrophysiological data from the cat spinal cord, in order to examine the effects of variations in neuron size and input resistance and of conductance magnitude and duration on the generation of excitatory ...
A, Lev-Tov +3 more
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Journal of Neurophysiology, 2004
In the rat, some findings have been taken to suggest the existence of monosynaptic corticomotoneuronal (CM) connections. Because this connection is believed to be largely responsible for the ability to make independent digit movements in primates and man, it has been inferred that the monosynaptic CM connection in the rat is likewise important for ...
B, Alstermark, J, Ogawa, T, Isa
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In the rat, some findings have been taken to suggest the existence of monosynaptic corticomotoneuronal (CM) connections. Because this connection is believed to be largely responsible for the ability to make independent digit movements in primates and man, it has been inferred that the monosynaptic CM connection in the rat is likewise important for ...
B, Alstermark, J, Ogawa, T, Isa
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Geological Society, London, Special Publications, 2016
Abstract The international DOPAS Project (Demonstration Of Plugs And Seals), which involves the participation of 14 European organizations (Posiva, ANDRA, DBE-TEC, GRS, NAGRA, RWA, SÚRAO, SKB, CTU, NRG, GSL, BTECH, VTT and ÚJV Řež), is concerned with the structural solution for sealing plugs to be used in deep geological radioactive waste ...
Jiří Svoboda +5 more
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Abstract The international DOPAS Project (Demonstration Of Plugs And Seals), which involves the participation of 14 European organizations (Posiva, ANDRA, DBE-TEC, GRS, NAGRA, RWA, SÚRAO, SKB, CTU, NRG, GSL, BTECH, VTT and ÚJV Řež), is concerned with the structural solution for sealing plugs to be used in deep geological radioactive waste ...
Jiří Svoboda +5 more
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ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. G. ALBERG +4 more
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. G. ALBERG +4 more
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The Effects of Anticonvulsant Drugs on NMDA-EPSP, AMPA-EPSP, and GABA-IPSP in the Rat Hippocampus
Brain Research Bulletin, 1997The effects of phenobarbital, phenytoin, and valproic acid on pharmacologically isolated NMDA-EPSP, AMPA-EPSP, and GABA-IPSPs were examined in rat hippocampal slices. Phenobarbital (0.05 mg/ml) had no effect on the NMDA-EPSP, but decreased the slope of the AMPA-EPSP by 13.4% and facilitated the GABA-IPSP slope by 77.12%.
G Y, Ko, L M, Brown-Croyts, T J, Teyler
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The Catalytic Mechanism of EPSP Synthase Revisited
Biochemistry, 1999Recent analysis of EPSP synthase by solid-state NMR has led to the postulation of a new enzyme reaction pathway and raised once again the question of an intermediate species covalently bound to the enzyme [Studelska, D., McDowell, L., Espe, M., Klug, C., and Schaefer, J. (1997) Biochemistry 36, 15555-15560].
J, Lewis, K A, Johnson, K S, Anderson
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Journal of the American Chemical Society, 2012
Proton transfer to carbon atoms is a significant catalytic challenge because of the large intrinsic energetic barrier and the frequently unfavorable thermodynamics. The main catalytic challenge for enolpyruvylshikimate 3-phosphate synthase (EPSP synthase, AroA) is protonating the methylene carbon atom of phosphoenolpyruvate, or EPSP, in the reverse ...
Meiyan, Lou +5 more
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Proton transfer to carbon atoms is a significant catalytic challenge because of the large intrinsic energetic barrier and the frequently unfavorable thermodynamics. The main catalytic challenge for enolpyruvylshikimate 3-phosphate synthase (EPSP synthase, AroA) is protonating the methylene carbon atom of phosphoenolpyruvate, or EPSP, in the reverse ...
Meiyan, Lou +5 more
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Biochemistry, 1995
Numerous studies have confirmed that glyphosate forms a tight ternary complex with EPSP synthase and shikimate 3-phosphate. It has been proposed [Anton, D., Hedstrom, L., Fish, S., & Abeles, R. (1983) Biochemistry 22, 5903-5908; Steinrücken, H. C., & Amrhein, N. (1984) Eur. J. Biochem.
R D, Sammons +4 more
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Numerous studies have confirmed that glyphosate forms a tight ternary complex with EPSP synthase and shikimate 3-phosphate. It has been proposed [Anton, D., Hedstrom, L., Fish, S., & Abeles, R. (1983) Biochemistry 22, 5903-5908; Steinrücken, H. C., & Amrhein, N. (1984) Eur. J. Biochem.
R D, Sammons +4 more
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Journal of the American Chemical Society, 1992
A number of analogues of the intermediate and product of the enzyme EPSP synthase are described. Inert analogues that show high affinity for the enzyme from Petunia hybrida are produced by replacing the labile ketal phosphate moiety of this intermediate with a phosphonate or by stabilizing the ketal phosphate against ionization through introduction of ...
David G. Alberg +4 more
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A number of analogues of the intermediate and product of the enzyme EPSP synthase are described. Inert analogues that show high affinity for the enzyme from Petunia hybrida are produced by replacing the labile ketal phosphate moiety of this intermediate with a phosphonate or by stabilizing the ketal phosphate against ionization through introduction of ...
David G. Alberg +4 more
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Journal of Biomolecular Structure and Dynamics, 2013
Although the proposed mechanisms are reasonable, there are still many questions about the 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase mechanism that are difficult to answer by experimental means alone. EPSP synthase is a key enzyme in the shikimic acid pathway, which is found only in plants and some micro-organisms and is also molecular target ...
Melissa Soares, Caetano +3 more
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Although the proposed mechanisms are reasonable, there are still many questions about the 5-enolpyruvyl shikimate-3-phosphate (EPSP) synthase mechanism that are difficult to answer by experimental means alone. EPSP synthase is a key enzyme in the shikimic acid pathway, which is found only in plants and some micro-organisms and is also molecular target ...
Melissa Soares, Caetano +3 more
openaire +2 more sources