Results 171 to 180 of about 26,317 (223)

The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action. [PDF]

open access: yesNat Commun
Vestring S   +43 more
europepmc   +1 more source

DOPAS EPSP experiment

Geological Society, London, Special Publications, 2016
Abstract The international DOPAS Project (Demonstration Of Plugs And Seals), which involves the participation of 14 European organizations (Posiva, ANDRA, DBE-TEC, GRS, NAGRA, RWA, SÚRAO, SKB, CTU, NRG, GSL, BTECH, VTT and ÚJV Řež), is concerned with the structural solution for sealing plugs to be used in deep geological radioactive waste ...
Jiří Svoboda   +5 more
openaire   +1 more source

Lack of Monosynaptic Corticomotoneuronal EPSPs in Rats: Disynaptic EPSPs Mediated Via Reticulospinal Neurons and Polysynaptic EPSPs Via Segmental Interneurons

Journal of Neurophysiology, 2004
In the rat, some findings have been taken to suggest the existence of monosynaptic corticomotoneuronal (CM) connections. Because this connection is believed to be largely responsible for the ability to make independent digit movements in primates and man, it has been inferred that the monosynaptic CM connection in the rat is likewise important for ...
B, Alstermark, J, Ogawa, T, Isa
openaire   +2 more sources

Transition State Analysis of Enolpyruvylshikimate 3-Phosphate (EPSP) Synthase (AroA)-Catalyzed EPSP Hydrolysis

Journal of the American Chemical Society, 2012
Proton transfer to carbon atoms is a significant catalytic challenge because of the large intrinsic energetic barrier and the frequently unfavorable thermodynamics. The main catalytic challenge for enolpyruvylshikimate 3-phosphate synthase (EPSP synthase, AroA) is protonating the methylene carbon atom of phosphoenolpyruvate, or EPSP, in the reverse ...
Meiyan, Lou   +5 more
openaire   +2 more sources

Reduced corticomotoneuronal excitatory postsynaptic potentials (EPSPs) with normal Ia afferent EPSPs in amyotrophic lateral sclerosis

Neurology, 1996
We studied excitatory postsynaptic potentials (EPSPs) arising in single spinal motoneurons (composite EPSPs) induced by Ia afferent and magnetic cortical stimulation in 28 normal subjects ranging in age from 24 to 84 years and 28 patients with amyotrophic lateral sclerosis (ALS) aged 34 to 82 years. The subjects voluntarily recruited single motor units
M, Nakajima   +4 more
openaire   +2 more sources

The Catalytic Mechanism of EPSP Synthase Revisited

Biochemistry, 1999
Recent analysis of EPSP synthase by solid-state NMR has led to the postulation of a new enzyme reaction pathway and raised once again the question of an intermediate species covalently bound to the enzyme [Studelska, D., McDowell, L., Espe, M., Klug, C., and Schaefer, J. (1997) Biochemistry 36, 15555-15560].
J, Lewis, K A, Johnson, K S, Anderson
openaire   +2 more sources

Reevaluating Glyphosate as a Transition-State Inhibitor of EPSP Synthase: Identification of an EPSP Synthase.cntdot.EPSP.cntdot.Glyphosate Ternary Complex

Biochemistry, 1995
Numerous studies have confirmed that glyphosate forms a tight ternary complex with EPSP synthase and shikimate 3-phosphate. It has been proposed [Anton, D., Hedstrom, L., Fish, S., & Abeles, R. (1983) Biochemistry 22, 5903-5908; Steinrücken, H. C., & Amrhein, N. (1984) Eur. J. Biochem.
R D, Sammons   +4 more
openaire   +2 more sources

ChemInform Abstract: Inhibition of EPSP Synthase by Analogues of the Tetrahedral Intermediate and of EPSP.

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. G. ALBERG   +4 more
openaire   +1 more source

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