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The Epstein-Barr Virus and Neoplasia
New England Journal of Medicine, 1975Epstein–Barr virus (EBV) is a lymphotropic herpes virus in man.1 Its main target is the human B lymphocyte.2 Only B lymphocytes and most if not all B lymphocytes have specific EBV receptors.3 Recent evidence suggests that the complement receptor of the B lymphocyte is either identical or closely associated with EBV receptor (Jondal M, Klein G, Oldstone
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Pediatrics In Review, 1994
Introduction Virtually all humans become infected with Epstein-Barr virus (EBV). The vast majority of these infections are inapparent, occur early in life, and are associated with lifelong latent infection and persistent shedding of virus.
W A, Durbin, J L, Sullivan
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Introduction Virtually all humans become infected with Epstein-Barr virus (EBV). The vast majority of these infections are inapparent, occur early in life, and are associated with lifelong latent infection and persistent shedding of virus.
W A, Durbin, J L, Sullivan
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Epstein-Barr Virus and Astrocytoma
Critical Reviews™ in Oncogenesis, 2019Epstein-Barr virus (EBV) is an established pathogen linked to a wide range of lymphoproliferative disorders and solid tumors. Astrocytoma is one of the most frequent brain tumors in children, adolescents, and young adults. Astrocyte proliferation usually occurs after brain tissue aggression, which may be of different types, including viral infection ...
Freixo, Cristiana +2 more
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New England Journal of Medicine, 2000
The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr.1 Four years later, in 1968, EBV was shown to be the etiologic agent of heterophile-positive infectious mononucleosis.2 EBV DNA was detected in tissues from patients with nasopharyngeal carcinoma ...
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The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr.1 Four years later, in 1968, EBV was shown to be the etiologic agent of heterophile-positive infectious mononucleosis.2 EBV DNA was detected in tissues from patients with nasopharyngeal carcinoma ...
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The Epstein-Barr Virus Proteins
1988Publisher Summary This chapter reviews the molecular biology of Epstein–Barr virus (EBV) proteins. Genes expressed in the virus-transformed B cells are usually referred to as “latent.” The complex expression of the EBV genome in transformed B cells is likely to reflect a functional diversity of the various expressed proteins.
J, Dillner, B, Kallin
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The Epstein-Barr virus in autoimmunity
Springer Seminars in Immunopathology, 1995EBV, which is one of the viruses that most of us live with throughout most of our lifetimes, is capable of inducing autoantibodies reactive with a variety of normal tissue proteins. Because of this, the virus remains a constant threat for autoimmunization during our lifetimes, and this threat is in fact realized in several autoimmune diseases.
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Epstein‐Barr virus and gastric carcinoma
Pathology International, 2010Epstein‐Barr virus (EBV) has been accepted as an infective agent causing gastric carcinoma (GC). Epstein‐Barr virus‐associated GC, comprising nearly 10% of all cases of GC, is the monoclonal growth of EBV‐infected epithelial cells, which express several EBV‐latent genes (latency I program).
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Epstein-Barr Virus and Autoimmunity
1996Epstein-Barr virus (EBV) is a ubiquitous member of the human herpesvirus group. The virus is the agent of infectious mononucleosis (IM) and shows the peculiar capability of immortalizing human B lymphocytes in vivo and in vitro; EBV is also associated with the development of African Burkitt’s lymphoma (BL), undifferentiated nasopharyngeal carcinoma ...
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Epstein-barr virus in multiple sclerosis
Current Neurology and Neuroscience Reports, 2009Recent seroepidemiologic and pathologic evidence suggests that prior infection with Epstein-Barr virus (EBV) may be necessary for the development of multiple sclerosis (MS). EBV infects more than 90% of all humans, most of whom remain healthy. In contrast, 99% of MS patients have evidence of prior infection with EBV.
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