Results 41 to 50 of about 112,758 (355)

Epstein–Barr virus in the multiple sclerosis brain: a controversial issue—report on a focused workshop held in the Centre for Brain Research of the Medical University of Vienna, Austria [PDF]

, 2011
Recent epidemiological and immunological studies provide evidence for an association between Epstein–Barr virus infection and multiple sclerosis, suggesting a role of Epstein–Barr virus infection in disease induction and pathogenesis.
Ascherio, Bonnet, Brink, Casola, Centonze, Chen, de Sanjose, Dukers, Esiri, F. Aloisi, Flanagan, G. Niedobitek, Gilligan, Gires, Glaser, Grasser, Grinstein, Gruhne, Gulley, H. Lassmann, Hadinoto, Hamilton-Dutoit, Handel, He, Hennard, Herbst, Herrmann, Heussinger, Hislop, Holm  y, Houali, Hudnall, H  llsberg, J. M. Middeldorp, Jafari, Jaquiery, Khan, Khan, Khan, Kis, Laichalk, Lang, Lassmann, Levin, Lu, Lucchinetti, Lunemann, Magliozzi, Magliozzi, Middeldorp, Middeldorp, Miller, Morre, Murray, Murray, Nicholls, Niedobitek, Niedobitek, Niedobitek, Niedobitek, Niedobitek, Niedobitek, Niedobitek, Niller, Owens, Panagopoulos, Paschos, Pegtel, Pender, Portis, Preciado, Prineas, Ressing, Salvetti, Saridakis, Sears, Serafini, Serafini, Shah, Sivachandran, Stevens, Stevens, Sundstrom, Swaminathan, Thorley-Lawson, Thorley-Lawson, Torkildsen, Tsai, Wang, Webster-Cyriaque, Yates, Young, Zhang   +92 more
core   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Etiological and clinical features of infectious complications in hemoblastosis

Онкогематология, 2022
The aim of the study was to analyze the etiologys of infectious complications (especially the role of respiratory viruses in patients with haematological malignancies).
V. N. Chebotkevich, V. V. Burylev, E. I. Kaytandzhan, S. S. Bessmeltsev, E. R. Shilova, S. B. Yatsyshina, A. V. Kudryavtseva   +6 more
doaj  

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Mining for viral fragments in methylation enriched sequencing data [PDF]

, 2015
Most next generation sequencing experiments generate more data than is required for the experimental set up. For example, methyl-CpG binding domain (MBD) affinity purification based sequencing is often used for DNA-methylation profiling, but up to 30% of
Ed eSchuuring, G. Bea A. Wisman, Klaas eMensaert, Olivier eThas, Renske D. M. Steenbergen, Tim eDe Meyer, Wim eVan Criekinge, Wim eVan Criekinge   +7 more
core   +4 more sources

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell transfer applications

Molecular Therapy: Methods & Clinical Development, 2023
Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients.
Darya Palianina, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice Schlatter, Sai T. Reddy, Nina Khanna   +5 more
doaj   +1 more source

Atrophic gastritis, Epstein-Barr virus infection, and Epstein-Barr virus-associated gastric carcinoma [PDF]

Gastric Cancer, 1999
BACKGROUND: The developmental process of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) has not been clearly demonstrated, especially in its relation to intestinal metaplasia and epithelial EBV infection.METHODS: Gastritis and intestinal metaplasia was histologically evaluated in non-neoplastic gastric mucosa that surrounded early ...
Yasuharu, Kaizaki, Shinji, Sakurai, Ja-Mun, Chong, Masashi, Fukayama   +3 more
openaire   +2 more sources