Results 51 to 60 of about 1,980,096 (243)

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell transfer applications

Molecular Therapy: Methods & Clinical Development, 2023
Adoptive cell therapy of donor-derived, antigen-specific T cells expressing native T cell receptors (TCRs) is a powerful strategy to fight viral infections in immunocompromised patients.
Darya Palianina, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice Schlatter, Sai T. Reddy, Nina Khanna   +5 more
doaj   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Special Issue: Epstein–Barr–Virus–Associated Cancers

, 2021
Epstein–Barr virus (EBV), a ubiquitous human gamma herpesvirus, infects a majority of the population worldwide (~95%) [...
Asuka Nanbo
core   +1 more source

First Report of Uniparental Isodisomy of Chromosome 15 Revealing Angelman Syndrome and Microphthalmia Associated With a Novel Homozygous ALDH1A3 Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Paternal isodisomy of chromosome 15 (iUPD15) is a recognized cause of Angelman syndrome (AS), accounting for approximately 2%–5% of cases. Additionally, another recognized consequence of iUPD is the unmasking of autosomal recessive disorders. However, reports of recessive disorders resulting from iUPD15 remain scarce in the literature.
Gabriela Roldão Correia‐Costa, Joana Rosa Marques Prota, Antonia Paula Marques‐de‐Faria, Carlos Eduardo Steiner, Társis Paiva Vieira   +4 more
wiley   +1 more source

19th International Symposium on Epstein–Barr Virus and Associated Diseases, 29–30 July 2021, Asahikawa, Japan

, 2022
SIMPLE SUMMARY: Novel insights into the basic and translational findings on Epstein–Barr virus-related diseases were presented at the “19th International Symposium on Epstein–Barr Virus and Associated Diseases” in Asahikawa, Japan.
Takumi Kumai, Yasuaki Harabuchi, Kumai, Takumi, Miki Takahara, Harabuchi, Yasuaki, Takahara, Miki   +5 more
core   +1 more source

Type I Interferon Drives Dysfunction of a Distinct CD8+ HLA‐DRB1+ T Cell Subset in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long, Elio Carmona, Mikhail G. Dozmorov, Amr H. Sawalha   +3 more
wiley   +1 more source

How Human Tumor Viruses Make Use of Autophagy

Cells, 2012
Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect
Bill Sugden, Zachary L. Pratt
doaj   +1 more source

Scales of Magt1 Gene: Novel Mutations, Different Presentations

Iranian Journal of Allergy, Asthma and Immunology, 2022
Loss-of-function mutations in magnesium transporter 1 (MAGT1) gene cause X-linked magnesium deficiency with Epstein–Barr virus (EBV) infection and neoplasm (X-MEN), a disease with quite diverse clinical and immunological consequences.
Sule Haskologlu, Kubra Baskin, Caner Aytekin, Candan Islamoglu, Serdar Ceylaner, Figen Dogu, Nurdan Tacyildiz, Emel Unal, Aydan Ikinciogullari   +8 more
doaj   +1 more source

Epstein-Barr virus infection in children with AIDS [PDF]

Jornal de Pediatria, 1998
OBJECTIVE: The association of the HIV and Epstein-Barr virus infections has been reported in several studies, specially in children that present lymphocytic interstitial pneumonitis. The analysis of the incidence of Epstein-Barr virus infection was performed in children with AIDS, in those with AIDS with and without lymphocytic interstitial pneumonitis,
A P, Carvalho, L V, Gandolfi, E, Tonelli
openaire   +2 more sources