Results 91 to 100 of about 8,244 (227)

Impact of bridging thrombolysis versus endovascular thrombectomy alone on outcomes in anticoagulated patients with atrial fibrillation and acute ischaemic stroke

European Journal of Neurology, Volume 31, Issue 12, December 2024.
Abstract Background and purpose The impact of bridging thrombolysis prior to endovascular thrombectomy (EVT) compared to EVT alone on intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH), and death in anticoagulated atrial fibrillation (AF) patients with acute ischaemic stroke (AIS) is not well defined.
Muath Alobaida, Stephanie L. Harrison, Deirdre A. Lane, Fiona Rowe, Philip Austin, Azmil H. Abdul‐Rahim, Gregory Y. H. Lip   +6 more
wiley   +1 more source

A novel strategy for site selective spin-labeling to investigate bioactive entities by DNP and EPR spectroscopy

Scientific Reports, 2021
A novel specific spin-labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the venom of certain rattlesnakes.
Kevin Herr, Max Fleckenstein, Martin Brodrecht, Mark V. Höfler, Henrike Heise, Fabien Aussenac, Torsten Gutmann, Michael Reggelin, Gerd Buntkowsky   +8 more
doaj   +1 more source

Pharmacotherapy of Acute Coronary Syndromes: Medical Economics with an Emphasis on Clopidogrel [PDF]

, 2018
Summary: Acute coronary syndromes account worldwide for a significant burden of hospital- and societal costs. Pharmacotherapy of acute coronary syndromes consists of a combined antithrombotic therapy.
Bramkamp, Matthias, Dedes, Konstantin, Szucs, Thomas   +2 more
core  

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +2 more sources

Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment

Annals of Neurology, Volume 96, Issue 5, Page 871-886, November 2024.
Clinicians fear thrombolysis after direct oral anticoagulant (DOAC) use due to experience with warfarin. In contrast to vitamin K antagonists such as warfarin, DOACs prevent thrombosis by blocking thrombin. Clinical observational data suggest that thrombolysis may be safe in the setting of DOAC use.
Sanaz Monjazeb, Heather V. Chang, Patrick D. Lyden   +2 more
wiley   +1 more source

A critical review of therapeutic interventions in sickle cell disease: Progress and challenges

Archiv der Pharmazie, Volume 357, Issue 11, November 2024.
Sickle cell disease reflects a complex interplay of genetics, hematology, and clinical symptoms. The intricate pathogenesis of the disease offers a landscape with various targets and treatment options. Anticipated advancements in treatment include combining fetal hemoglobin inducers with other drug classes to improve the efficacy beyond monotherapy ...
Chandu Ala, Renuka Parshuram Joshi, Pragya Gupta, Sangam Giri Goswami, Sivaprakash Ramalingam, Chandra Sekhar Kondapalli Venkata Gowri, Murugesan Sankaranarayanan   +6 more
wiley   +1 more source

Comparison between Intracoronary Abciximab and Intravenous Eptifibatide Administration during Primary Percutaneous Coronary Intervention of Acute ST-Segment Elevation Myocardial Infarction

Journal of Tehran University Heart Center, 2015
Background: Administration of glycoprotein IIb/IIIa inhibitors is an effective adjunctive treatment strategy during primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI).
MohammadHasan Namazi, Morteza Safi, Hosein Vakili, Habibollah Saadat, Esfandiar Karimi, Ramin Khameneh-Bagheri   +5 more
doaj  

Ultrasound enhanced prehospital thrombolysis using microbubbles infusion in patients with acute ST elevation myocardial infarction: Rationale and design of the Sonolysis study [PDF]

, 2008
Contains fulltext : 70525.pdf (publisher's version ) (Open Access)ABSTRACT: BACKGROUND -: Experimental studies have shown that ultrasound contrast agents enhance the effectiveness of thrombolytic agents in the presence of ultrasound in ...
A van Wamel, AM Ross, Arie PJ van Dijk, AV Alexandrov, AW 't Hof, CA Molina, CM Gibson, F Van de Werf, F Xie, Freek WA Verheugt, Gertjan T Sieswerda, I Kondo, J Wu, Jeroen Slikkerveer, K Mizushige, K Tachibana, LJ Juffermans, MG Cohen, Otto Kamp, PA Dijkmans, PA Dijkmans, Pieter A Dijkmans, Pieter AFM Doevendans, RA Lichtveld, RJ Siegel, S Pfaffenberger, T Nishioka, Thomas R Porter, TR Porter, WC Culp, Y Birnbaum   +30 more
core   +6 more sources

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

Journal of Peptide Science, Volume 30, Issue 11, November 2024.
This review provides an overview of FDA‐approved peptides, particularly those targeting cardiovascular diseases, human immunodeficiency, and central nervous system diseases, and also addresses conditions such as osteoporosis, thrombocytopenia, Cushing's disease, and hypoglycemia.
Othman Al Musaimi
wiley   +1 more source

Therapeutic Plasma Exchange to Reverse Plasma Failure in Multiple Organ Dysfunction Syndrome

Journal of Clinical Apheresis, Volume 39, Issue 5, October 2024.
ABSTRACT Plasma plays a crucial role in maintaining health through regulating coagulation and inflammation. Both are essential to respond to homeostatic threats such as traumatic injury or microbial infection; however, left unchecked, they can themselves cause damage.
Matthew J. Foglia, Jay S. Raval, Jan C. Hofmann, Joseph A. Carcillo   +3 more
wiley   +1 more source