Results 111 to 120 of about 40,172 (233)
eQTL Viewer: visualizing how sequence variation affects genome-wide transcription
BMC Bioinformatics, 2007 Background Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression variations. To map eQTL, thousands of expression profiles are related with sequence polymorphisms across the genome ...
Zeng Zhao-Bang, Aylor David L, Zou Wei
doaj +1 more source
PLoS Computational Biology, 2020 A longstanding goal of regulatory genetics is to understand how variants in genome sequences lead to changes in gene expression. Here we present a method named Bayesian Annotation Guided eQTL Analysis (BAGEA), a variational Bayes framework to model cis ...
David Lamparter +5 more
doaj +1 more source
Journal of Integrative Plant Biology, EarlyView.ABSTRACT Transcriptome deep sequencing (RNA‐seq) data analysis is often affected by reference bias introduced by the use of a single linear reference (SLR) genome. Graph‐based pangenomes can mitigate this bias by integrating the SLR genome with complex genetic variations within a species; however, their application remains limited owing to a lack of ...
Yifan Bu +10 more
wiley +1 more source
A Principled Framework for Mendelian Randomization in Oral Health Research
Journal of Periodontal Research, EarlyView.This methodological article provides a clear and accessible overview of Mendelian randomization for oral health researchers, emphasizing the core assumptions needed for credible causal inference. Focusing on applications in oral health, particularly periodontitis, it highlights both the strengths and limitations of the study design in order to support ...
Nasir Z. Bashir +5 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Free amino acids (FAAs) play a fundamental role in determining fruit quality and stress adaptation, yet their genetic regulation remains poorly understood. Through an integrated approach combining metabolomic and sensory analyses of 120 peach (Prunus persica) hybrids, we identified glutamate as a key metabolite linking FAA content to umami ...
Yike Su +8 more
wiley +1 more source
eQTLs in platelets and iPSC-megakaryocytes [PDF]
Blood, 2021 Elizabeth A, Middleton, Jesse W, Rowley
openaire +2 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Chromatin interactions establish spatial proximity between distant regulatory elements and their target genes, significantly influencing gene expression, and phenotypic traits. In this study, we present a plant chromatin interaction prediction model called PlantCTCIP based on Convolutional Neural Networks and Transformer.
Zhenye Wang +14 more
wiley +1 more source
Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. [PDF]
, 2019 The cardiac transcription factor (TF) gene NKX2-5 has been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common regulatory variants contributes
Benaglio, Paola +17 more
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