Results 111 to 120 of about 46,677 (295)

Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents

Cell Proliferation, EarlyView.
Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...
Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen   +13 more
wiley   +1 more source

Genetic control of longissimus dorsi muscle gene expression variation and joint analysis with phenotypic quantitative trait loci in pigs

BMC Genomics, 2019
Background Economically important growth and meat quality traits in pigs are controlled by cascading molecular events occurring during development and continuing throughout the conversion of muscle to meat.
Deborah Velez-Irizarry, Sebastian Casiro, Kaitlyn R. Daza, Ronald O. Bates, Nancy E. Raney, Juan P. Steibel, Catherine W. Ernst   +6 more
doaj   +1 more source

Genetic risk factor identification for common epilepsies guided by integrative omics data analysis

Epilepsia, EarlyView.
Abstract Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...
Ashwini Mushunuri, Oluyomi Adesoji, Roland Krause, Patrick May, Holger Lerche, Albert Becker, Daniela Grimm, International League Against Epilepsy Consortium on Complex Epilepsies, Michael Nothnagel, Herbert Schulz   +9 more
wiley   +1 more source

Segregation of regulatory polymorphisms with effects on the gluteus medius transcriptome in a purebred pig population.

PLoS ONE, 2012
BackgroundThe main goal of the present study was to analyse the genetic architecture of mRNA expression in muscle, a tissue with an outmost economic importance for pig breeders.
Angela Cánovas, Ramona N Pena, David Gallardo, Oscar Ramírez, Marcel Amills, Raquel Quintanilla   +5 more
doaj   +1 more source

Expression Quantitative Trait Loci (eQTL) Mapping in Korean Patients With Crohn’s Disease and Identification of Potential Causal Genes Through Integration With Disease Associations

Frontiers in Genetics, 2020
Background Expression quantitative trait loci (eQTL) datasets have extensively been used to help interpret genome-wide association study signals. Most eQTL analyses have been conducted with populations of European ancestry.
Seulgi Jung, Wenting Liu, J. Baek, Jung Won Moon, B. Ye, Ho-Su Lee, S. Park, Suk-Kyun Yang, B. Han, Jianjun Liu, K. Song   +10 more
semanticscholar   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

eQTLMAPT: Fast and Accurate eQTL Mediation Analysis With Efficient Permutation Testing Approaches

Frontiers in Genetics, 2020
Expression quantitative trait locus (eQTL) analyses are critical in understanding the complex functional regulatory natures of genetic variation and have been widely used in the interpretation of disease-associated variants identified by genome-wide ...
Tao Wang, Qidi Peng, Bo Liu, Xiaoli Liu, Yongzhuang Liu, Jiajie Peng, Yadong Wang   +6 more
semanticscholar   +1 more source

An eQTL-based Approach Reveals Candidate Regulators of LINE-1 RNA Levels in Lymphoblastoid Cells [PDF]

, 2023
Juan I. Bravo, Chanelle R. Mizrahi, Seungsoo Kim, Lucia Zhang, Yousin Suh, Bérénice A. Benayoun   +5 more
openalex   +1 more source

The PbrMADS1–PbrMYB169 complex has uniquely emerged to regulate lignification of stone cells in pear

Journal of Integrative Plant Biology, EarlyView.
Genome‐wide association study in pear identified a SEP3‐subfamily transcription factor, PbrMADS1, which interacts with PbrMYB169 to regulate stone cell lignification. The methionine at position 63 in PbrMADS1 was essential for this interaction. This amino acid variation may underlie the functional divergence of homologous SEP3 genes among Rosaceae ...
Yongsong Xue, Shulin Chen, Yingyu Hao, Meng Shan, Pengfei Zheng, Runze Wang, Mingyue Zhang, Jun Wu, Cheng Xue   +8 more
wiley   +1 more source

New cases of δ‐aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model

Journal of Internal Medicine, EarlyView.
Abstract Background Dysfunction of δ‐aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood‐onset disease inherited in an autosomal recessive manner, whereas the acquired form usually affects adults due to enzyme ...
Elena Di Pierro, Isabel Solares, Daniel Jericó, Francisco J. Castelbón, Javier Tomás Solera, Antoni Riera‐Mestre, María Barreda‐Sánchez, Carlo Poci, Annamaria Nicolli, Francesco Urigo, Ana Sampedro, Rafael Enríquez de Salamanca, Matteo Marcacci, Matías A. Ávila, Pauline Harper, Marta G. Fanlo‐Maresma, Encarna Guillén‐Navarro, Giovanna Graziadei, Andrea Wenzel, Bodo B. Beck, Paolo Ventura, Montserrat Morales‐Conejo, Antonio Fontanellas   +22 more
wiley   +1 more source