A brief guide to analyzing expression quantitative trait loci [PDF]
Molecules and Cells: Molecular quantitative trait locus (molQTL) mapping has emerged as an important approach for elucidating the functional consequences of genetic variants and unraveling the causal mechanisms underlying diseases or complex traits. However, the variety of
Byung Su Ko, Sung Bae Lee, Tae-Kyung Kim
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Integrating transcriptomic and genomic studies for the identification of expression quantitative trait loci associated with bovine paratuberculosis [PDF]
Frontiers in Veterinary ScienceThe study of the genetic basis underlying the host response to Mycobacterium avium subsp. paratuberculosis (MAP) is usually performed using genome-wide association studies (GWAS), which assess the individual association between genotyped markers ...
Gerard Badia-Bringué +1 more
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MicroRNAs and rs1803274 SNP-based BuChe downregulation are associated with metabolic syndrome through ghrelin hydrolysis and expression quantitative trait loci regulation in PD patients [PDF]
Frontiers in Molecular NeuroscienceIntroductionMetabolic syndrome (MetS) and Parkinson’s disease (PD) share common pathophysiological and molecular impairments related to high PD incidence in MetS patients.
Guenson Chevalier +8 more
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Placental expression quantitative trait loci in an East Asian population [PDF]
HGG AdvancesSummary: Expression quantitative trait loci (eQTL) analysis measures the contribution of genetic variation in gene expression on complex traits. Although this methodology has been used to examine gene regulation in numerous human tissues, eQTL research ...
Jaeyong Choi +12 more
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Expression quantitative trait loci influence DNA damage-induced apoptosis in cancer [PDF]
BMC GenomicsBackground Genomic instability and evading apoptosis are two fundamental hallmarks of cancer and closely linked to DNA damage response (DDR). By analyzing expression quantitative trait loci (eQTL) upon cell stimulation (called exposure eQTL (e2QTL)) it ...
Jessica Bigge +8 more
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Variable expression quantitative trait loci analysis of breast cancer risk variants [PDF]
Scientific Reports, 2021 Genome wide association studies (GWAS) have identified more than 180 variants associated with breast cancer risk, however the underlying functional mechanisms and biological pathways which confer disease susceptibility remain largely unknown.
George A. R. Wiggins +5 more
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Integrating single cell expression quantitative trait loci summary statistics to understand complex trait risk genes [PDF]
Nature CommunicationsTranscriptome-wide association study (TWAS) is a popular approach to dissect the functional consequence of disease associated non-coding variants. Most existing TWAS use bulk tissues and may not have the resolution to reveal cell-type specific target ...
Lida Wang +9 more
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Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas
Cells, 2023 In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella +12 more
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Expression Quantitative Trait Loci (eQTLs) Associated with Retrotransposons Demonstrate their Modulatory Effect on the Transcriptome [PDF]
International Journal of Molecular Sciences, 2021 Sulev Koks +2 more
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Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice
Journal of Lipid Research, 2011 To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc +6 more
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