Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research [PDF]
, 2005 Alcoholism is a complex disease exhibiting a multifactorial mode of transmission. To simplify the genetic and phenotypic complexity of the alcoholic phenotype, alcohol-preferring (P) and -non-preferring (NP) rats were developed on the basis of alcohol ...
Carr, Lucinda G. +4 more
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Frontiers in Cell and Developmental Biology, 2022 An enormous challenge in the post-genome era is to annotate and resolve the consequences of genetic variation on diverse phenotypes. The genome-wide association study (GWAS) is a well-known method to identify potential genetic loci for complex traits ...
Kai Yuan +7 more
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Hierarchical modeling of clinical and expression quantitative trait loci [PDF]
Heredity, 2008 Previous articles have presented clinical quantitative trait locus (cQTL) models, where the information provided by quantitative/qualitative phenotypes, molecular markers and gene expressions (transcription levels) were combined and analyzed simultaneously.
M J, Sillanpää, N, Noykova
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Bayesian Detection of Expression Quantitative Trait Loci Hot Spots [PDF]
Genetics, 2011 Abstract High-throughput genomics allows genome-wide quantification of gene expression levels in tissues and cell types and, when combined with sequence variation data, permits the identification of genetic control points of expression (expression QTL or eQTL).
Leonardo, Bottolo +6 more
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Multiple locus linkage analysis of genomewide expression in yeast. [PDF]
PLoS Biology, 2005 With the ability to measure thousands of related phenotypes from a single biological sample, it is now feasible to genetically dissect systems-level biological phenomena.
John D Storey +2 more
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Bayesian Partition Models for Identifying Expression Quantitative Trait Loci [PDF]
Journal of the American Statistical Association, 2015 Expression quantitative trait loci (eQTLs) are genomic locations associated with changes of expression levels of certain genes. By assaying gene expressions and genetic variations simultaneously on a genome-wide scale, scientists wish to discover genomic loci responsible for expression variations of a set of genes.
Jiang, Bo, Liu, Jun
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Variation in the flowering time orthologs BrFLC and BrSOC1 in a natural population of Brassica rapa. [PDF]
, 2015 Understanding the genetic basis of natural phenotypic variation is of great importance, particularly since selection can act on this variation to cause evolution.
Franks, Steven J +7 more
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Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study
BMC Genomics, 2008 Background Many studies have shown that the abundance level of gene expression is heritable. Analogous to the traditional genetic study, most researchers treat the expression of one gene as a quantitative trait and map it to expression quantitative trait
Sun Wei, Yuan Shinsheng, Li Ker-Chau
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<i>SCFD1</i> expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed. [PDF]
Brain Commun, 2021 Abstract Evidence indicates that common variants found in genome-wide association studies increase risk of disease through gene regulation via expression Quantitative Trait Loci. Using multiple genome-wide methods, we examined if Single Nucleotide Polymorphisms increase risk of Amyotrophic Lateral Sclerosis through expression ...
Iacoangeli A +25 more
europepmc +6 more sources
RTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analyses [PDF]
, 2014 Our database tool, called Real-Time Engine for Expression Quantitative Trait Loci Analyses (RTeQTL), can efficiently provide eQTL association results that are not available in existing eQTL databases browsers.
Huang, Jinyan +2 more
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