Results 31 to 40 of about 134,736 (276)

Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

G3: Genes, Genomes, Genetics, 2016
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping.
Martin Johnsson, Kenneth B. Jonsson, Leif Andersson, Per Jensen, Dominic Wright   +4 more
doaj   +1 more source

A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. [PDF]

, 2018
Although cancer genomes are replete with noncoding mutations, the effects of these mutations remain poorly characterized. Here we perform an integrative analysis of 930 tumor whole genomes and matched transcriptomes, identifying a network of 193 ...
Bojorquez-Gomez, Ana, Carter, Hannah, Chen, Kevin, Farley, Emma K, Fraley, Stephanie I, Huang, Justin K, Ideker, Trey, Kreisberg, Jason F, Licon, Katherine, Melton, Collin, Olson, Katrina M, Sanchez, Kyle S, Shen, John Paul, Snyder, Michael, Velez, Daniel Ortiz, Xu, Guorong, Yu, Michael Ku, Zhang, Wei   +17 more
core   +1 more source

Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

Life Science Alliance, 2020
This comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types. At least 200 single-nucleotide polymorphisms (SNPs) are associated with multiple sclerosis (MS) risk.
Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven   +18 more
doaj   +1 more source

Expression quantitative trait loci associated with Nellore meat pH. [PDF]

, 2023
Genomic studies make it possible to identify polymorphisms associated with quantitative characteristics of economic interest, such as meat pH, a factor that influences meat ...
BEATRIZ, D. L., COUTINHO, L. L., GARCIA, I. S., REGITANO, L. C. de A., SILVA, T. R. da, SILVA-VIGNATO, B.   +5 more
core  

Single cell expression quantitative trait loci and complex traits [PDF]

Genome Medicine, 2013
The recently developed ability to quantify mRNA abundance and noise in single cells has allowed the effect of heritable variations on gene function to be re-evaluated. A recent study has shown that major sources of variation are masked when gene expression is averaged over many cells.
openaire   +4 more sources

Determining causality and consequence of expression quantitative trait loci [PDF]

Human Genetics, 2014
Expression quantitative trait loci (eQTLs) are currently the most abundant and systematically-surveyed class of functional consequence for genetic variation. Recent genetic studies of gene expression have identified thousands of eQTLs in diverse tissue types for the majority of human genes.
A, Battle, S B, Montgomery
openaire   +2 more sources

Loci nominally associated with autism from genome-wide analysis show enrichment of brain expression quantitative trait loci but not lymphoblastoid cell line expression quantitative trait loci

Molecular Autism, 2012
Background Autism spectrum disorder is a severe early onset neurodevelopmental disorder with high heritability but significant heterogeneity. Traditional genome-wide approaches to test for an association of common variants with autism susceptibility risk
Davis Lea K, Gamazon Eric R, Kistner-Griffin Emily, Badner Judith A, Liu Chunyu, Cook Edwin H, Sutcliffe James S, Cox Nancy J   +7 more
doaj   +1 more source

Genomic regions associated with common root rot resistance in the barley variety Delta [PDF]

, 2010
Common root rot (CRR) caused by Bipolaris sorokiniana is a serious disease constraint in the dry temperate cereal growing regions of the world. Currently little is known about the genetic control of resistance to CRR in cereals.
Bovill, J., Lehmensiek, A., McNamara, R. B., Sutherland, M. W.   +3 more
core   +2 more sources

Recent Advances in Genetics of the Spontaneously Hypertensive Rat [PDF]

, 2010
The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the ...
Michal Pravenec, Theodore W. Kurtz
core   +3 more sources

Expression quantitative trait loci for PI3K/AKT pathway

Medicine, 2017
A genome-wide association study (GWAS) was conducted to identify expression quantitative trait loci (eQTLs) for the genes involved in phosphatidylinositol-3-kinase/v-akt murine thymoma viral oncogene homolog (PI3K/AKT) pathway.Data on mRNA expression of 341 genes in lymphoblastoid cell lines of 373 Europeans recruited by the 1000 Genomes Project using ...
Ryu, Dongchan, Lee, Chaeyoung
openaire   +2 more sources