Results 1 to 10 of about 84,882 (161)
OmiGA for ultra-efficient molecular quantitative trait loci mapping [PDF]
Nature CommunicationsMolecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts of genomic variants, leading to advanced understanding of the regulatory mechanisms underpinning complex traits and
Jinyan Teng +6 more
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Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits [PDF]
Nature CommunicationsGenome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific
Lida Wang +8 more
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Bayes factors for detection of Quantitative Trait Loci [PDF]
Genetics Selection Evolution, 2001 A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel +2 more
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Overcoming collaboration barriers in quantitative trait loci analysis [PDF]
Cell GenomicsIn this issue of Cell Genomics, Choi et al.1 report a novel approach, privateQTL, which leverages secure multiparty computation (MPC) to enable federated expression quantitative trait loci (eQTL) mapping across institutions without compromising data ...
Wen Zhang, Xiaohong Wu, Jing Gong
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Secure and federated quantitative trait loci mapping with privateQTL [PDF]
Cell GenomicsSummary: Understanding the relationship between genotypes and phenotypes is crucial for advancing personalized medicine. Expression quantitative trait loci (eQTL) mapping plays a significant role by correlating genetic variants to gene expression levels.
Yoolim Annie Choi +4 more
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Quantitative Trait Loci: A Meta-analysis [PDF]
Genetics, 2000 Abstract This article presents a method to combine QTL results from different independent analyses. This method provides a modified Akaike criterion that can be used to decide how many QTL are actually represented by the QTL detected in different experiments. This criterion is computed to choose between models with one, two, three, etc.,
Goffinet, Bruno, Gerber, Sophie
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Investigation of Splicing Quantitative Trait Loci in [PDF]
Genomics & Informatics, 2016 The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo +3 more
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Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes
Biology, 2022 Since Darwin, biologists have sought to understand the evolution and origins of phenotypic adaptations. The skull is particularly diverse due to intense natural selection on feeding biomechanics.
Leah DeLorenzo +8 more
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Quantitative Trait Loci for Murine Growth [PDF]
Genetics, 1996 Abstract Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice.
Cheverud J.M. +5 more
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Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas
Cells, 2023 In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella +12 more
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