Results 1 to 10 of about 83,180 (256)

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits [PDF]

Nature Communications
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific
Lida Wang, Shuang Gao, Siyuan Chen, Havell Markus, Gao Wang, Laura Carrel, Xiang Zhan, Dajiang J. Liu, Bibo Jiang   +8 more
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OmiGA for ultra-efficient molecular quantitative trait loci mapping [PDF]

Nature Communications
Molecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts of genomic variants, leading to advanced understanding of the regulatory mechanisms underpinning complex traits and
Jinyan Teng, Wenjing Zhang, Wentao Gong, Jiajian Chen, Yahui Gao, Lingzhao Fang, Zhe Zhang   +6 more
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Overcoming collaboration barriers in quantitative trait loci analysis [PDF]

Cell Genomics
In this issue of Cell Genomics, Choi et al.1 report a novel approach, privateQTL, which leverages secure multiparty computation (MPC) to enable federated expression quantitative trait loci (eQTL) mapping across institutions without compromising data ...
Wen Zhang, Xiaohong Wu, Jing Gong
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Powerful one-dimensional scan to detect heterotic quantitative trait loci [PDF]

Nature Communications
To meet the growing global demand for food, increasing yields through heterosis in agriculture is crucial. A deep understanding of the genetic basis of heterosis has led to the development of a quantitative genetic framework that incorporates both ...
Guoliang Li, Renate H. Schmidt, Yusheng Zhao, Jochen C. Reif, Yong Jiang   +4 more
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Secure and federated quantitative trait loci mapping with privateQTL [PDF]

Cell Genomics
Summary: Understanding the relationship between genotypes and phenotypes is crucial for advancing personalized medicine. Expression quantitative trait loci (eQTL) mapping plays a significant role by correlating genetic variants to gene expression levels.
Yoolim Annie Choi, Yebin Kim, Peihan Miao, Tuuli Lappalainen, Gamze Gürsoy   +4 more
doaj   +2 more sources

Investigation of Splicing Quantitative Trait Loci in [PDF]

Genomics & Informatics, 2016
The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo, Sungkyu Kyung, Seonggyun Han, Sangsoo Kim   +3 more
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Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes

Biology, 2022
Since Darwin, biologists have sought to understand the evolution and origins of phenotypic adaptations. The skull is particularly diverse due to intense natural selection on feeding biomechanics.
Leah DeLorenzo, Victoria DeBrock, Aldo Carmona Baez, Patrick J. Ciccotto, Erin N. Peterson, Clare Stull, Natalie B. Roberts, Reade B. Roberts, Kara E. Powder   +8 more
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Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

Cells, 2023
In this study, we attempted to find genetic variants affecting gene expression (eQTL = expression Quantitative Trait Loci) in the human placenta in normal and pathological situations.
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Géraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sébastien Jacques, Colin E. Murdoch, Francisco Miralles, Céline Méhats, Daniel Vaiman   +12 more
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Mapping Splicing Quantitative Trait Loci in RNA-Seq

Cancer Informatics, 2014
Background One of the major mechanisms of generating mRNA diversity is alternative splicing, a regulated process that allows for the flexibility of producing functionally different proteins from the same genomic sequences.
Cheng Jia, Yu Hu, Yichuan Liu, Mingyao Li   +3 more
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Heterotic quantitative trait loci analysis and genomic prediction of seedling biomass-related traits in maize triple testcross populations

Plant Methods, 2021
Background Heterosis has been widely used in maize breeding. However, we know little about the heterotic quantitative trait loci and their roles in genomic prediction.
Tifu Zhang, Lu Jiang, Long Ruan, Yiliang Qian, Shuaiqiang Liang, Feng Lin, Haiyan Lu, Huixue Dai, Han Zhao   +8 more
doaj   +1 more source