Results 31 to 40 of about 3,758,767 (255)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

An eQTL analysis of partial resistance to Puccinia hordei in barley [PDF]

, 2010
Background - Genetic resistance to barley leaf rust caused by Puccinia hordei involves both R genes and quantitative trait loci. The R genes provide higher but less durable resistance than the quantitative trait loci. Consequently, exploring quantitative
Hackett, Christine A, Vels, S.A., Ramsay, L., Thierry C Marcel, Milne, I., Hedley, Peter E., Druka, Arnis, Booth, C., Luke Ramsay, Marshall, David, Hedley, P.E., Cardle Linda, Marcel, Thierry C., Marcel, Thierry, T., Cardle, Linda, Linda Cardle, Ramsay, Luke, Anton Vels, Hedley Peter E., Marshall, D., Druka Arnis, Hackett Christine A., Milne, Iain, Waugh, R., Milne Iain, Xinwei Chen, Niks, R.E., Vels Anton, Booth Clare, Ramsay Luke, Bayer Micha, Druka, A., Clare Booth, Cardle, L., Marcel Thierry C., Christine A Hackett, Booth, Clare, Waugh, Robbie; id_orcid, Chen, Xinwei, Niks Rients E., Rients E Niks, Hackett, C.A., Milne, Lain, Vels, Anton, Iain Milne, Peter E Hedley, Marcel, T.C., Arnis Druka, Bayer, M., Morris, J., Morris Jenny, Marcel, Thierry, Micha Bayer, Robbie Waugh, Bayer, Micha, Hedley, Peter E, Chen Xinwei, Hackett, Christine A., Waugh, Robbie, Waugh Robbie, Jenny Morris, David Marshall, Niks, Rients E., Niks, Rients E, Marshall David, Morris, Jenny   +65 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Quantitative trait loci mapping of panicle traits in rice.

Molecular biology research communications, 2019
In this study 90 individuals of recombinant inbred lines (RILs) were developed by crossing subspecies of japonica rice cultivar, 'Nagdong' and an indica type cultivar, 'Cheongcheong'. These individuals were used to identify the quantitative trait loci of panicle traits using SSR markers.
Jia, Baoyan, Zhao, Xinhua, Qin, Yang, Irfan, Muhammad, Kim, Tae-heon, Wang, Bolun, Wang, Shu, Sohn, Jae   +7 more
openaire   +2 more sources

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Quantitative trait loci for physical activity traits in mice

Physiological Genomics, 2008
The genomic locations and identities of the genes that regulate voluntary physical activity are presently unknown. The purpose of this study was to search for quantitative trait loci (QTL) that are linked with daily mouse running wheel distance, duration, and speed of exercise. F2animals ( n = 310) derived from high active C57L/J and low active C3H/HeJ
J Timothy, Lightfoot, Michael J, Turner, Daniel, Pomp, Steven R, Kleeberger, Larry J, Leamy   +4 more
openaire   +3 more sources

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Mapping carcass and meat quality QTL on Sus Scrofa chromosome 2 in commercial finishing pigs [PDF]

, 2009
Quantitative trait loci (QTL) affecting carcass and meat quality located on SSC2 were identified using variance component methods. A large number of traits involved in meat and carcass quality was detected in a commercial crossbred population: 1855 pigs ...
Knol, A.J., Bovenhuis, H., Egbert F Knol, Bovenhuis Henk, Knol, E.F., Heuven, H.C.M., van Kampen, T.A., Bert Dibbits, Kampen, A.J.A., van, van Wijk, R.H.J., Henk Bovenhuis, Dibbits, B.W., Dibbits, B., Henri CM Heuven, Knol Egbert F, Tony A van Kampen, Dibbits Bert, van Wijk Rik HJ, Rik HJ van Wijk, Wijk, H.J., van, Heuven Henri CM, van Kampen Tony A, Advances in Veterinary Medicine, Geneeskunde van gezelschapsdieren   +23 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source