Results 21 to 30 of about 83,180 (256)

Mapping Environment-Specific Quantitative Trait Loci [PDF]

Genetics, 2010
Abstract Environment-specific quantitative trait loci (QTL) refer to QTL that express differently in different environments, a phenomenon called QTL-by-environment (Q × E) interaction. Q × E interaction is a difficult problem extended from traditional QTL mapping.
Xin, Chen, Fuping, Zhao, Shizhong, Xu
openaire   +2 more sources

Quantitative Trait Loci for Murine Growth [PDF]

Genetics, 1996
Abstract Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice.
Cheverud J.M., Routman E.J., Duarte F.A.M., Van Swinderen B., Cothran K., Perel C.   +5 more
openaire   +2 more sources

Genetic regulation of cholesterol absorption and plasma plant sterol levels

Journal of Lipid Research, 2003
The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP
Ephraim Sehayek
doaj   +1 more source

Mapping and Validation of Quantitative Trait Loci for Root Architectural Traits in Rice (Oryza sativa) under Non-Stress and Salinity Stress Conditions

Tropical Agricultural Research, 2018
Root architectural traits are governed by many genes exhibiting polygenic inheritance. The dissection of the genetic basis of root traits could be achieved by mapping of quantitative trait loci (QTLs) using molecular markers.
D. R. Gimhani, B. P. Abhayawickrama, M. S. F. Saliha, N. S. Kottearachchi   +3 more
doaj   +1 more source

Mapping quantitative trait loci underlying triploid endosperm traits [PDF]

Heredity, 2003
Endosperm, which is derived from two polar nuclei fusing with one sperm, is a triploid tissue in cereals. Endosperm tissue determines the grain quality of cereals. Improving grain quality is one of the important breeding objectives in cereals. However, current statistical methods for mapping quantitative trait loci (QTL) under diploid genetic control ...
C, Xu, X, He, S, Xu
openaire   +2 more sources

Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases

HGG Advances
Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs ...
Yao Fu, Jennifer A. Kelly, Jaanam Gopalakrishnan, Richard C. Pelikan, Kandice L. Tessneer, Satish Pasula, Kiely Grundahl, David A. Murphy, Patrick M. Gaffney   +8 more
doaj   +1 more source

Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice

Journal of Lipid Research, 2011
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc, Rachael S. Hageman, Ricardo A. Verdugo, Shirng-Wern Tsaih, Kenneth Walsh, Gary A. Churchill, Beverly Paigen   +6 more
doaj   +1 more source

Bayes factors for detection of Quantitative Trait Loci

Genetics Selection Evolution, 2001
A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel, García-Cortés Luis, Varona Luis   +2 more
doaj   +1 more source

Linkage disequilibrium interval mapping of quantitative trait loci

BMC Genomics, 2006
Background For many years gene mapping studies have been performed through linkage analyses based on pedigree data. Recently, linkage disequilibrium methods based on unrelated individuals have been advocated as powerful tools to refine estimates of gene ...
de Rochambeau Hubert, Abdallah Jihad, Boitard Simon, Cierco-Ayrolles Christine, Mangin Brigitte   +4 more
doaj   +1 more source

Interpreting Functional Impact of Genetic Variations by Network QTL for Genotype–Phenotype Association Study

Frontiers in Cell and Developmental Biology, 2022
An enormous challenge in the post-genome era is to annotate and resolve the consequences of genetic variation on diverse phenotypes. The genome-wide association study (GWAS) is a well-known method to identify potential genetic loci for complex traits ...
Kai Yuan, Tao Zeng, Tao Zeng, Tao Zeng, Luonan Chen, Luonan Chen, Luonan Chen, Luonan Chen   +7 more
doaj   +1 more source