Results 11 to 20 of about 3,726,731 (344)

Genetic mapping of quantitative trait loci in crops

Crop Journal, 2017
Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists. Two complementary approaches for genetic mapping, linkage mapping and association mapping have led to successful dissection of complex traits in many crop ...
Yang Xu, Pengcheng Li, Zefeng Yang, Chenwu Xu   +3 more
doaj   +2 more sources

Bayes factors for detection of Quantitative Trait Loci [PDF]

Genetics Selection Evolution, 2001
A fundamental issue in quantitative trait locus (QTL) mapping is to determine the plausibility of the presence of a QTL at a given genome location. Bayesian analysis offers an attractive way of testing alternative models (here, QTL vs.
Pérez-Enciso Miguel, García-Cortés Luis, Varona Luis   +2 more
doaj   +4 more sources

OmiGA for ultra-efficient molecular quantitative trait loci mapping [PDF]

Nature Communications
Molecular quantitative trait loci (molQTL) mapping is one of the most popular approaches to systematically characterize functional impacts of genomic variants, leading to advanced understanding of the regulatory mechanisms underpinning complex traits and
Jinyan Teng, Wenjing Zhang, Wentao Gong, Jiajian Chen, Yahui Gao, Lingzhao Fang, Zhe Zhang   +6 more
doaj   +2 more sources

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits [PDF]

Nature Communications
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific
Lida Wang, Shuang Gao, Siyuan Chen, Havell Markus, Gao Wang, Laura Carrel, Xiang Zhan, Dajiang J. Liu, Bibo Jiang   +8 more
doaj   +2 more sources

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

PLoS Genetics, 2010
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues.
Andrew Singleton, Juan Troncoso, Mark Cookson   +2 more
exaly   +2 more sources

Molecular Genetic Dissection of Quantitative Trait Loci Regulating Rice Grain Size

Annual Review of Genetics, 2014
Jiayang Li, Jianru Zuo
exaly   +2 more sources

A compendium of uniformly processed human gene expression and splicing quantitative trait loci

Nature Genetics, 2021
Many gene expression quantitative trait locus (eQTL) studies have published their summary statistics, which can be used to gain insight into complex human traits by downstream analyses, such as fine mapping and co-localization.
N. Kerimov, J. Hayhurst, Kateryna Peikova, J. Manning, P. Walter, Liis Kolberg, Marija Samoviča, Manoj Pandian Sakthivel, I. Kuzmin, S. Trevanion, Tony Burdett, S. Jupp, H. Parkinson, I. Papatheodorou, Andrew D. Yates, D. Zerbino, K. Alasoo   +16 more
semanticscholar   +1 more source

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability

Nature Genetics, 2021
Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3′
Lei Li, Kai-Lieh Huang, Yipeng Gao, Ya Cui, Gao Wang, Nathan D. Elrod, Yu-Mei Li, Y. Chen, Ping Ji, Fanglue Peng, William K. Russell, E. Wagner, Wei Li   +12 more
semanticscholar   +1 more source

Expression quantitative trait loci: present and future

Philosophical Transactions of the Royal Society B: Biological Sciences, 2013
Emmanouil Dermitzakis, Alexandra C Nica
exaly   +2 more sources

Investigation of Splicing Quantitative Trait Loci in [PDF]

Genomics & Informatics, 2016
The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. Here,
Wonseok Yoo, Sungkyu Kyung, Seonggyun Han, Sangsoo Kim   +3 more
doaj   +1 more source