Results 51 to 60 of about 134,736 (276)

A Statistical Framework for Expression Quantitative Trait Loci Mapping [PDF]

Genetics, 2007
AbstractIn 2001, Sen and Churchill reported a general Bayesian framework for quantitative trait loci (QTL) mapping in inbred line crosses. The framework is a powerful one, as many QTL mapping methods can be represented as special cases and many important considerations are accommodated.
Meng, Chen, Christina, Kendziorski
openaire   +2 more sources

A geometric interpretation of the permutation $p$-value and its application in eQTL studies [PDF]

, 2010
Permutation $p$-values have been widely used to assess the significance of linkage or association in genetic studies. However, the application in large-scale studies is hindered by a heavy computational burden.
Sun, Wei, Wright, Fred A.
core   +3 more sources

A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. [PDF]

PLoS Genetics, 2011
We conducted a comprehensive study of copy number variants (CNVs) well-tagged by SNPs (r(2)≥ 0.8) by analyzing their effect on gene expression and their association with disease susceptibility and other complex human traits.
Eric R Gamazon, Dan L Nicolae, Nancy J Cox   +2 more
doaj   +1 more source

Development of a Next-Generation NIL Library in Arabidopsis Thaliana for Dissecting Complex Traits [PDF]

, 2013
The identification of the loci and specific alleles underlying variation in quantitative traits is an important goal for evolutionary biologists and breeders.
Bauerle, William L., Fletcher, Richard S., Juenger, Thomas E., McKay, John K., Meyer, Eli, Mullen, Jack L., Reuning, Gretchen, Sen, Saunak, Yoder, Seth   +8 more
core   +3 more sources

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits

Nature Communications
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific
Lida Wang, Shuang Gao, Siyuan Chen, Havell Markus, Gao Wang, Laura Carrel, Xiang Zhan, Dajiang J. Liu, Bibo Jiang   +8 more
doaj   +1 more source

Replication and discovery of musculoskeletal QTLs in LG/J and SM/J advanced intercross lines [PDF]

, 2018
AR056280 awarded to DAB and AL. AIHC supported by IMS and Elphinstone Scholarship from the University of Aberdeen.
Blizard, David A, Carbonetto, Peter, Gregory, Jennifer S, Gyekis, Joseph P, Hernandez Cordero, Ana I, Lionikas, Arimantas, Vandenbergh, David J, Verri, Gioia Riboni   +7 more
core   +1 more source

Variants at IRX4 as prostate cancer expression quantitative trait loci [PDF]

European Journal of Human Genetics, 2013
Genome-wide association studies (GWAS) have identified numerous prostate cancer-associated risk loci. Some variants at these loci may be regulatory and influence expression of nearby genes. Such loci are known as cis-expression quantitative trait loci (cis-eQTL).
X. Xu, W. M. Hussain, J. Vijai, K. Offit, M. A. Rubin, Demichelis, Francesca, R. J. Klein   +6 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density. [PDF]

, 2016
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone ...
Bian, Zhaolian, Chen, Haoyan, Gershwin, M Eric, Jiang, Xiang, Li, Enling, Li, Zhiqiang, Lian, Min, Liao, Wilson, Ma, Xiong, Miao, Qi, Seldin, Michael F, Shi, Yongyong, Tang, Ruqi, Wang, Qixia, Wang, Zhaoyue, Wei, Yiran, Yang, Fan, Yang, Yue, Zhang, Haiyan   +18 more
core   +2 more sources