Results 21 to 30 of about 70,079 (283)

Genetic complexity at expression quantitative trait loci [PDF]

BMC Proceedings, 2016
Identifying variants that regulate gene expression and delineating their genetic architecture is a critical next step in our endeavors to better understand the genetic etiology of complex diseases. The appropriate genomic tools are in place, and preliminary analytic strategies have been developed.Here we used Genetic Analysis Workshop (GAW) 19 data to ...
Cantor, Rita M., Pan, Calvin, Siegmund, Kimberly   +2 more
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Expression quantitative trait loci analysis in plants [PDF]

Plant Biotechnology Journal, 2009
SummaryAn expression Quantitative Trait Locus or eQTL is a chromosomal region that accounts for a proportion of the variation in abundance of a mRNA transcript observed between individuals in a genetic mapping population. A single gene can have one or multiple eQTLs. Large scale mRNA profiling technologies advanced genome‐wide eQTL mapping in a diverse
Druka, Arnis, Potokina, Elena, Luo, Zewei, Jiang, Ning, Chen, Xinwei, Kearsey, Mike, Waugh, Robbie   +6 more
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Comparing Quantitative Trait Loci and Gene Expression Data [PDF]

Advances in Bioinformatics, 2008
We develop methods to compare the positions of quantitative trait loci (QTL) with a set of genes selected by other methods, such as microarray experiments, from a sequenced genome. We apply our methods to QTL for addictive behavior in mouse, and a set of genes upregulated in a region of the brain associated with addictive behavior, the nucleus ...
Bing Han, Naomi S. Altman, Jessica A. Mong, Laura Cousino Klein, Donald W. Pfaff, David J. Vandenbergh   +5 more
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<i>SCFD1</i> expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed. [PDF]

Brain Commun, 2021
Evidence indicates that common variants found in genome-wide association studies increase risk of disease through gene regulation via expression Quantitative Trait Loci.
Iacoangeli A, Fogh I, Selvackadunco S, Topp SD, Shatunov A, van Rheenen W, Al-Khleifat A, Opie-Martin S, Ratti A, Calvo A, UK Brain Expression Consortium , Van Damme P, Robberecht W, Chio A, Dobson RJ, Hardiman O, Shaw CE, van den Berg LH, Andersen PM, Smith BN, Silani V, Veldink JH, Breen G, Troakes C, Al-Chalabi A, Jones AR.   +25 more
europepmc   +2 more sources

Determining causality and consequence of expression quantitative trait loci [PDF]

Human Genetics, 2014
Expression quantitative trait loci (eQTLs) are currently the most abundant and systematically-surveyed class of functional consequence for genetic variation. Recent genetic studies of gene expression have identified thousands of eQTLs in diverse tissue types for the majority of human genes.
A, Battle, S B, Montgomery
openaire   +2 more sources

The role of heritability in mapping expression quantitative trait loci [PDF]

BMC Proceedings, 2007
Abstract Gene expression, as a heritable complex trait, has recently been used in many genome-wide linkage studies. The estimated overall heritability of each trait may be considered as evidence of a genetic contribution to the total phenotypic variation, which implies the possibility of mapping genome regions responsible for the gene ...
Huang, Song, Ballard, David, Zhao, Hongyu   +2 more
openaire   +2 more sources

Hierarchical modeling of clinical and expression quantitative trait loci [PDF]

Heredity, 2008
Previous articles have presented clinical quantitative trait locus (cQTL) models, where the information provided by quantitative/qualitative phenotypes, molecular markers and gene expressions (transcription levels) were combined and analyzed simultaneously.
M J, Sillanpää, N, Noykova
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A Statistical Framework for Expression Quantitative Trait Loci Mapping [PDF]

Genetics, 2007
AbstractIn 2001, Sen and Churchill reported a general Bayesian framework for quantitative trait loci (QTL) mapping in inbred line crosses. The framework is a powerful one, as many QTL mapping methods can be represented as special cases and many important considerations are accommodated.
Meng, Chen, Christina, Kendziorski
openaire   +2 more sources

An eQTL analysis of partial resistance to Puccinia hordei in barley [PDF]

, 2010
Background - Genetic resistance to barley leaf rust caused by Puccinia hordei involves both R genes and quantitative trait loci. The R genes provide higher but less durable resistance than the quantitative trait loci. Consequently, exploring quantitative
Hackett, Christine A, Vels, S.A., Ramsay, L., Thierry C Marcel, Milne, I., Hedley, Peter E., Druka, Arnis, Booth, C., Luke Ramsay, Marshall, David, Hedley, P.E., Cardle Linda, Marcel, Thierry C., Marcel, Thierry, T., Cardle, Linda, Linda Cardle, Ramsay, Luke, Anton Vels, Hedley Peter E., Marshall, D., Druka Arnis, Hackett Christine A., Milne, Iain, Waugh, R., Milne Iain, Xinwei Chen, Niks, R.E., Vels Anton, Booth Clare, Ramsay Luke, Bayer Micha, Druka, A., Clare Booth, Cardle, L., Marcel Thierry C., Christine A Hackett, Booth, Clare, Waugh, Robbie; id_orcid, Chen, Xinwei, Niks Rients E., Rients E Niks, Hackett, C.A., Milne, Lain, Vels, Anton, Iain Milne, Peter E Hedley, Marcel, T.C., Arnis Druka, Bayer, M., Morris, J., Morris Jenny, Marcel, Thierry, Micha Bayer, Robbie Waugh, Bayer, Micha, Hedley, Peter E, Chen Xinwei, Hackett, Christine A., Waugh, Robbie, Waugh Robbie, Jenny Morris, David Marshall, Niks, Rients E., Niks, Rients E, Marshall David, Morris, Jenny   +65 more
core   +1 more source

Characterization of Expression Quantitative Trait Loci in the Human Colon [PDF]

Inflammatory Bowel Diseases, 2015
Many genetic risk loci have been identified for inflammatory bowel disease and colorectal cancer; however, identifying the causal genes for each association signal remains a challenge. Expression quantitative trait loci (eQTL) studies have identified common variants that induce differential gene expression and eQTLs can be cross-referenced with disease
Singh, Tarjinder, Levine, Adam P., Smith, Philip J., Smith, Andrew M., Segal, Anthony W., Barrett, Jeffrey C.   +5 more
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