Results 21 to 30 of about 134,736 (276)

Liver expression quantitative trait loci: a foundation for pharmacogenomic research [PDF]

Frontiers in Genetics, 2012
Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research.
Dylan eGlubb, Neepa eDholakia, Federico eInnocenti, Federico eInnocenti   +3 more
doaj   +3 more sources

Genetic complexity at expression quantitative trait loci [PDF]

BMC Proceedings, 2016
Identifying variants that regulate gene expression and delineating their genetic architecture is a critical next step in our endeavors to better understand the genetic etiology of complex diseases. The appropriate genomic tools are in place, and preliminary analytic strategies have been developed.Here we used Genetic Analysis Workshop (GAW) 19 data to ...
Cantor, Rita M., Pan, Calvin, Siegmund, Kimberly   +2 more
openaire   +2 more sources

Mapping Quantitative Trait Loci for Expression Abundance [PDF]

Genetics, 2007
Abstract Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1) individual
Zhenyu, Jia, Shizhong, Xu
openaire   +2 more sources

Cross-Talk of Expression Quantitative Trait Loci Within 2 Interacting Blood Pressure Quantitative Trait Loci [PDF]

Hypertension, 2007
Genetic dissection of the S rat genome has provided strong evidence for the presence of 2 interacting blood pressure quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown.
Norman H, Lee, Brian J, Haas, Noah E, Letwin, Bryan C, Frank, Truong V, Luu, Qiang, Sun, Carrie D, House, Shane, Yerga-Woolwine, Phyllis, Farms, Ezhilarasi, Manickavasagam, Bina, Joe   +10 more
openaire   +2 more sources

Comparing Quantitative Trait Loci and Gene Expression Data [PDF]

Advances in Bioinformatics, 2008
We develop methods to compare the positions of quantitative trait loci (QTL) with a set of genes selected by other methods, such as microarray experiments, from a sequenced genome. We apply our methods to QTL for addictive behavior in mouse, and a set of genes upregulated in a region of the brain associated with addictive behavior, the nucleus ...
Han, Bing, Altman, Naomi S., Mong, Jessica A., Klein, Laura Cousino, Pfaff, Donald W., Vandenbergh, David J.   +5 more
openaire   +2 more sources

Methods and Insights from Single-Cell Expression Quantitative Trait Loci. [PDF]

Annu Rev Genomics Hum Genet, 2023
Recent advancements in single-cell technologies have enabled expression quantitative trait locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk RNA sequencing, which averages gene expression across cell types and cell states, single-cell assays capture the transcriptional states of individual cells, including ...
Kang JB, Raveane A, Nathan A, Soranzo N, Raychaudhuri S.   +4 more
europepmc   +3 more sources

Cis -acting expression quantitative trait loci in mice [PDF]

Genome Research, 2005
We previously reported the analysis of genome-wide expression profiles and various diabetes-related traits in a segregating cross between inbred mouse strains C57BL/6J (B6) and DBA/2J (DBA). By considering transcript levels as quantitative traits, we identified several thousand expression quantitative trait loci (eQTL) with LOD ...
Doss, S, Schadt, E E, Drake, T A, Lusis, Aldons J   +3 more
openaire   +3 more sources

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice

Journal of Lipid Research, 2011
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc, Rachael S. Hageman, Ricardo A. Verdugo, Shirng-Wern Tsaih, Kenneth Walsh, Gary A. Churchill, Beverly Paigen   +6 more
doaj   +1 more source

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]

, 2005
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer, CE Muller-Sieburg, CS Potten, EE Schadt, ES Lander, F Lai, G de Haan, G De Haan, G De Haan, G Yvert, J Boultwood, J Klose, JL Peirce, LM Kamminga, M Ramalho-Santos, ML Wayne, NB Ivanova, NO Fortunel, P Hasty, RB Brem, RC Jansen, RC Jansen, SR Pearce, T Wiltshire, Y Ben-David   +24 more
core   +2 more sources