Results 191 to 200 of about 46,677 (295)

Statins Regulate Stem Cell Growth Factor‐β to Balance Osteogenesis and Adipogenesis in Mesenchymal Stem Cells, Endowing Anti‐Osteonecrosis Effects

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Dyslipidaemia has been implicated in osteonecrosis through some clinical studies. However, a direct causal relationship between hyperlipidaemia and osteonecrosis remains unconfirmed, and whether lipid‐lowering agents could be used to treat osteonecrosis remains unclear.
Fangzhou Fan, Yu Chen, Weiyan Peng, Wenlong Yan, Hao Tan, Chengxuan Zhang, Siyu Tan, Qian Xiao, Yuan Gao, Jian Zhang, Lei Liu, Chengjie Lian   +11 more
wiley   +1 more source

Cell type-specific inference from bulk RNA-sequencing data by integrating single-cell reference profiles via EPIC-unmix. [PDF]

Genome Biol
Tang C, Sun Q, Zeng X, Li G, Yang X, Liu F, Zhao J, Shen Y, Liu B, Wen J, Li Y.   +10 more
europepmc   +1 more source

Integrating apaQTL and eQTL analysis identifies a potential causal variant associated with lung adenocarcinoma risk in the Chinese population

Huiwen Xu, Yutong Wu, Qiong Chen, Yuhui Yu, Qianyao Meng, Na Qin, Wendi Zhang, Xiaobo Tao, Siqi Li, Tian Tian, Lei Zhang, Hongxia Ma, Jiahua Cui, Minjie Chu   +13 more
openalex   +1 more source

Banana breeding by genome design

Journal of Integrative Plant Biology, Volume 67, Issue 11, Page 2816-2847, November 2025.
Bananas and plantains likely originated from hybridizations of four wild Musa species. This review highlights advances in banana genomics, genetics, and breeding, emphasizing genome sequencing breakthroughs and genomic‐assisted tools like selection and gene editing, and explores future prospects for improving key agronomic traits.
Rida Arshad, Tayyaba Razzaq, Bilal Ahmad, Ting Hou, Chaochao Li, Zhongxin Jin, Wei Zhang, Zhongjie Liu, Hui‐Run Huang, Peitao Lü, Wei Wang, Xue‐Jun Ge, Yongfeng Zhou, Jianghui Xie   +13 more
wiley   +1 more source

Integrative Analysis of GEO Datasets and Mendelian Randomization Reveals a Potential Role ofISOC1 in Renal Cell Carcinoma. [PDF]

J Cancer
Wang J, Liu Y, Yan Z, Lu Q, Jian J, Liu X, Chen Z, Zheng Q, Wan S, Wang L.   +9 more
europepmc   +1 more source

Integrated Single‐Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease [PDF]

Xinhui Huang, Cheng Zhu, Shiqi Lv, Yulin Wang, Jiayi Wang, Songhua Yuan, Yue Yang, Xiaoqiang Ding, Xiaoyan Zhang   +8 more
openalex   +1 more source

Identification of eQTLs and sQTLs associated with meat quality in beef [PDF]

, 2019
Joel D. Leal‐Gutiérrez, Mauricio A. Elzo, Raluca G. Mateescu   +2 more
openalex   +1 more source

Hedgehog Components Are Present in Polymorphous Adenocarcinoma of the Salivary Gland Regardless of PRKD1 Mutation and Tissue Invasion

Journal of Oral Pathology &Medicine, Volume 54, Issue 10, Page 1053-1061, November 2025.
ABSTRACT Purpose Polymorphous adenocarcinoma of the salivary gland is characterized by cellular uniformity associated with a variety of morphological growth patterns, a fact that makes its diagnosis challenging. Therefore, the identification of genetic alterations and signaling pathways emerges as a tool for elucidation of the pathogenesis of this ...
Dandara Andrade De Santana, Cecília Vitória Lima De Oliveira, Flávia Caló De Aquino Xavier, Manoela Domingues Martins, Bruno Cunha Pires, Tercio Guimarães Reis, Patrícia Ramos Cury, Clarissa Araújo Gurgel, Maria Cristina Teixeira Cangussu, Daniel Araki Ribeiro, Victor Coutinho Bastos, Carolina Cavalieri Gomes, Jean Nunes Dos Santos   +12 more
wiley   +1 more source

Modeling heterogeneity in single-cell perturbation states enhances detection of response eQTLs. [PDF]

Nat Genet
Valencia C, Nathan A, Kang JB, Rumker L, Lee H, Raychaudhuri S.   +5 more
europepmc   +1 more source

COL6A1, LAPTM5, and ZFAND2A as Crucial Biomolecules Driving Immunoregulation in Human Nucleus Pulposus Degeneration

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
This study integrates single‐cell RNA sequencing, Mendelian randomization, and transcriptomics to investigate immune mechanisms in intervertebral disc degeneration. Single‐cell analysis of nucleus pulposus samples identified four major cell types. Mendelian randomization revealed key genes—COL6A1, LAPTM5, and ZFAND2A—associated with degeneration risk ...
Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Muradil Mardan, Meng‐Jia You, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng   +8 more
wiley   +1 more source